Q1MS70 (Q1MS70_LAWIP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150
Short name=AGPR HAMAP MF_00150
EC=1.2.1.38 HAMAP MF_00150

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase HAMAP MF_00150

Gene names

Name:	argC HAMAP MF_00150 EMBL CAJ54155.1
Ordered Locus Names:	LI0099

Organism

Lawsonia intracellularis (strain PHE/MN1-00) [Complete proteome] [HAMAP]

Taxonomic identifier

363253 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Lawsonia

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150 SAAS SAAS023013
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate. RuleBase RU004258 Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150 SAAS SAAS023013
Subcellular location	Cytoplasm By similarity HAMAP MF_00150 SAAS SAAS023013.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. HAMAP MF_00150

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis HAMAP MF_00150 SAAS SAAS023013
Cellular component	Cytoplasm HAMAP MF_00150 SAAS SAAS023013
Ligand	NADP HAMAP MF_00150 SAAS SAAS023013
Molecular function	Oxidoreductase HAMAP MF_00150 SAAS SAAS023013
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	156	1	By similarity HAMAP MF_00150

Sequences

	Sequence		Length	Mass (Da)
	Q1MS70 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 6F8B20D308E3C517	FASTA	353	39,108
	10 20 30 40 50 60 MGIQKIQAAI IGGTGYTGIE LIRLLSLHPN IQPIFIISRE QCGKKLYEVH PFLSGMPYAE 70 80 90 100 110 120 TIFSPLDHKA IGKTCDVAFL AVPHGTGMEI APQLLEQGTK VIDLSADFRL NNPMTYSQWY 130 140 150 160 170 180 HLEHNASHLL SEAVYGIPEL NEEFIKRANI VANPGCYPTS IILGLYPAIK HGLIKFENII 190 200 210 220 230 240 IDSKSGTSGA GRNTSTSSLL FCEIQNSFKA YNIGIHRHTP EIEQELSYIA KQPITVTFSP 250 260 270 280 290 300 HLLPTTRGIL STIYTQLALP ISQDEVYRLY TNTWKDQPWI RIVPSSKLPE TRNVCGTMFC 310 320 330 340 350 DIGLVVDIRT QRLIIISAID NLCRGASGQA IANANLMFNL PMTTGLIFCP LLP

References

[1]

"The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy." Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V. Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: PHE/MN1-00 EMBL CAJ54155.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180252 Genomic DNA. Translation: CAJ54155.1.
RefSeq	YP_594477.1. NC_008011.1.
3D structure databases
ProteinModelPortal	Q1MS70.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1MS70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4059377.
GenomeReviews	Gene locus LI0099 in contig AM180252_GR.
KEGG	lip:LI0099.
PATRIC	22303519. VBILawInt40445_0112.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	Q1MS70.
ProtClustDB	PRK00436.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1MS70_LAWIP

Accession

Primary (citable) accession number: Q1MS70

Entry history

Integrated into UniProtKB/TrEMBL:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)