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Q1MS17

- SYL_LAWIP

UniProt

Q1MS17 - SYL_LAWIP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei590 – 5901ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLINT363253:GH6E-159-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:LI0152
    OrganismiLawsonia intracellularis (strain PHE/MN1-00)
    Taxonomic identifieri363253 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
    ProteomesiUP000002430: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Leucine--tRNA ligasePRO_0000334768Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi363253.LI0152.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1MS17.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5411"HIGH" regionAdd
    BLAST
    Motifi587 – 5915"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1MS17-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMHSNYDPN IIEKKWQRYW EEQHAYACDI DPNKKKYYVL EMWPYPSGNI    50
    HMGHVRNYSI GDVIARIKRM QGYNVLHPMG WDAFGLPAEL AAIKHHTQPA 100
    DWTYTNINEM RAQLKRLGYS YDWQREIATC DPDYYQWEQL FFVDCFEKGL 150
    VYRKKAPQNW CPSCNTVLAN EQVIEGSCWR CDTSIIQKEL TQWFLKITDY 200
    AEELLDDLTT LKYSWPDRVI TMQENWLGKS TGVEISFPIE SSQDFITIFT 250
    TRPDTIFGAT AIILAPEHPI LETLLNDTPQ KEKLYNVIEK MRNMDRLERQ 300
    SNLLTKEGIF IDRYCINPCS GDKIPIWIGN FVLADYGTGA IMAVPAHDQR 350
    DFDFCKKYNL PISIVIQPDE LQINEHTIVE PWTGLGTLIH SGQFTGLTNK 400
    EAKEKITQYL EKIGKATRVV SWRLRDWNIS RQRYWGTPIP IIYCKNCGVV 450
    SVPKNELPVI LPTNITINED GSSPLPQESS FIDCMCPQCG GIAKRETDTM 500
    DTFVDSSWYF ARFVDPKNTK QPFDTSIAKY WLNVDQYIGG VEHAILHLLY 550
    SRFFTKLLRD LGYLPSNINE PFAKLLTQGM VIKDGSKMSK SKGNIVDPNQ 600
    MINIYGADTI RLFCLFAAPP ERDFDWSDSG IEGSYRFLHR VWRLFIDVQP 650
    HIHTTHAGNS TVIETTTALT KDVKRKEHIT IKKVSEDIEN KYQFNTAIAS 700
    IMEFVNTLYL SKNELILTVE GKNILSSAIA TVLTLLSPMT PHICEELWSY 750
    LGHSTSISLE PWPKWDPQAL LKDVVTIVVQ INGKVRNKFE VPMDLSKEEL 800
    EHIIFNDTKI TQYLEGKTIQ KHIIIPNKII NIVTT 835
    Length:835
    Mass (Da):96,315
    Last modified:May 30, 2006 - v1
    Checksum:i98E033A6AB677868
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180252 Genomic DNA. Translation: CAJ54208.1.
    RefSeqiYP_594530.1. NC_008011.1.

    Genome annotation databases

    GeneIDi4059645.
    KEGGilip:LI0152.
    PATRICi22303643. VBILawInt40445_0170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180252 Genomic DNA. Translation: CAJ54208.1 .
    RefSeqi YP_594530.1. NC_008011.1.

    3D structure databases

    ProteinModelPortali Q1MS17.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 363253.LI0152.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4059645.
    KEGGi lip:LI0152.
    PATRICi 22303643. VBILawInt40445_0170.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LINT363253:GH6E-159-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
      Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PHE/MN1-00.

    Entry informationi

    Entry nameiSYL_LAWIP
    AccessioniPrimary (citable) accession number: Q1MS17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3