Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate decarboxylase

Gene

gad

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciLINT363253:GH6E-270-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadImported
Ordered Locus Names:LI0261Imported
OrganismiLawsonia intracellularis (strain PHE/MN1-00)Imported
Taxonomic identifieri363253 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
ProteomesiUP000002430: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi363253.LI0261.

Structurei

3D structure databases

ProteinModelPortaliQ1MRQ9.
SMRiQ1MRQ9. Positions 37-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1MRQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATARKAVVK KMPVGHGTKR GSMGNRTQKS SMSNGVVRHE LLDDVFAEDD
60 70 80 90 100
LSQTLPKYQM PLYEHRPRDI YQAVHDELML DGNARQNLAT FCQTWVDPEI
110 120 130 140 150
HKLMDECVAK NMIDKDEYPQ TAELEMRCVN MLADLWNSPD PTNTIGCSAI
160 170 180 190 200
GSSEAAMLGG MALKWRWRAQ RKKAGKSTDK PNLVCGPVQI CWHKFARYWD
210 220 230 240 250
IELREIPMEK NRLIMSPEEA IKRCDENTIG VVPTLGVTYT GQYEPVEEVS
260 270 280 290 300
NALDALQKKK GWDIPIHVDA ASGGFLAPFI EPELVWDFRL PRVKSINSSG
310 320 330 340 350
HKFGLAPLGM GWVVWREKTD LPEDLIFWVN YLGSNIPTFA INFSRPGGQI
360 370 380 390 400
VCQYYNLLRL GREGYRRIHQ ACYDTTDYLA NELTKTGIFK ILYGGKTGIP
410 420 430 440 450
ALTWTLKDEK KYPFSLYDLS DRLRTRGWQV PAYSMPANRT DLVVMRVLVR
460 470 480 490 500
HGFDHDLADL LVNDIHRAIE HLKQNPRRKP LGSGQVTSYD HSGRSSIPQK

KK
Length:502
Mass (Da):57,125
Last modified:May 30, 2006 - v1
Checksum:i360AB851B33722E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA. Translation: CAJ54317.1.
RefSeqiYP_594638.1. NC_008011.1.

Genome annotation databases

GeneIDi4060314.
KEGGilip:LI0261.
PATRICi22303891. VBILawInt40445_0291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA. Translation: CAJ54317.1.
RefSeqiYP_594638.1. NC_008011.1.

3D structure databases

ProteinModelPortaliQ1MRQ9.
SMRiQ1MRQ9. Positions 37-476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi363253.LI0261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4060314.
KEGGilip:LI0261.
PATRICi22303891. VBILawInt40445_0291.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciLINT363253:GH6E-270-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
    Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PHE/MN1-00Imported.

Entry informationi

Entry nameiQ1MRQ9_LAWIP
AccessioniPrimary (citable) accession number: Q1MRQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.