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Q1MRA6 (Q1MRA6_LAWIP) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
Q1MRA6 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 8DE8CFFB416359D8

FASTA37842,377
        10         20         30         40         50         60 
MLVDKFILPE CKVYMCGHSL GPSLKTTSDA VCSTLQDFAS YGVSSWNKSG WIDLSYALGA 

        70         80         90        100        110        120 
KIAALVGAKF DEVIVCDSTV LNLFKALKVA MSLQNGRNII LTTDDNFPAD LYIAQGISEV 

       130        140        150        160        170        180 
KYIKSNEIYK NIDETVAVLM LTHVNYRDSS VLDMKTINEY AHKYGVLTVW DLSHSIGIVP 

       190        200        210        220        230        240 
VDLEESSTDF AVGCTYKYLS GGPGSPAFIY ANRMYHEHMQ SPIQGWIGHN QPFSFEKEYT 

       250        260        270        280        290        300 
SFGVRKFMSG TPAILSMKAL EAALEIFDKE VIVKSYSIAK EYSNILIKSL KSHGIEVYAP 

       310        320        330        340        350        360 
QNRGGHVAFM HKHGYAFSRA LIDAGFICDY RAPDLIRLCV NPLYISLRNI ESCIEQIQFI 

       370 
MERSLYLKPE YNQMQKVT 

« Hide

References

[1]"The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PHE/MN1-00 EMBL CAJ54470.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180252 Genomic DNA. Translation: CAJ54470.1.
RefSeqYP_594792.1. NC_008011.1.

3D structure databases

ProteinModelPortalQ1MRA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING363253.LI0415.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4060158.
KEGGlip:LI0415.
PATRIC22304233. VBILawInt40445_0459.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHOG000242437.
KOK01556.
OMAGWYGGDK.
OrthoDBEOG6N67XP.

Enzyme and pathway databases

BioCycLINT363253:GH6E-427-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ1MRA6_LAWIP
AccessionPrimary (citable) accession number: Q1MRA6
Entry history
Integrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 13, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)