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Q1MQL7

- ASSY_LAWIP

UniProt

Q1MQL7 - ASSY_LAWIP

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Protein
Argininosuccinate synthase
Gene
argG, LI0656
Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei89 – 891Citrulline By similarity
Binding sitei119 – 1191ATP; via amide nitrogen By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei129 – 1291Citrulline By similarity
Binding sitei177 – 1771Citrulline By similarity
Binding sitei186 – 1861Citrulline By similarity
Binding sitei262 – 2621Citrulline By similarity
Binding sitei274 – 2741Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLINT363253:GH6E-679-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:LI0656
OrganismiLawsonia intracellularis (strain PHE/MN1-00)
Taxonomic identifieri363253 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
ProteomesiUP000002430: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Argininosuccinate synthaseUniRule annotation
PRO_0000263935Add
BLAST

Proteomic databases

PRIDEiQ1MQL7.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi363253.LI0656.

Structurei

3D structure databases

ProteinModelPortaliQ1MQL7.
SMRiQ1MQL7. Positions 7-395.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1MQL7-1 [UniParc]FASTAAdd to Basket

« Hide

MSNRIKKVVL AYSGGLDTSV ILKWLIATYN CEVIAVTADL GQNENFHDIE    50
EKAIVTGASK AYVVDLRNEF AKNFIFPMLR ASAIYEGRYL LGTAIARPLI 100
TKLLIDIARA EEADAIAHGA TGKGNDQVRF ELAAAALAPD IHVIAPWREW 150
DLISRTALTT FAEKHNIPIS TSHKRYSKDQ NMLHCSIEGS ELENPWEEPH 200
IESYTMTVPI EHTPDSPEYI TIDFEKGDPI AINGQQMIPA DIMFTLNDIA 250
GRHGIGRIDM VESRFLGIKS RGVYETPGGT IIHIAHQDLE GITLDHMTLL 300
TRNQLIPSYA DAIYNGFWFS PEREAIQAFM DKAQERVTGT VKLKLYKGMA 350
YPIGRKSSNS LYSSQLATFE EDTSYNHNDA TGFIKLKSLR IRGYQKS 397
Length:397
Mass (Da):44,412
Last modified:May 30, 2006 - v1
Checksum:i0D1EB93309591409
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180252 Genomic DNA. Translation: CAJ54710.1.
RefSeqiYP_595031.1. NC_008011.1.

Genome annotation databases

GeneIDi4059380.
KEGGilip:LI0656.
PATRICi22304771. VBILawInt40445_0716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180252 Genomic DNA. Translation: CAJ54710.1 .
RefSeqi YP_595031.1. NC_008011.1.

3D structure databases

ProteinModelPortali Q1MQL7.
SMRi Q1MQL7. Positions 7-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 363253.LI0656.

Proteomic databases

PRIDEi Q1MQL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4059380.
KEGGi lip:LI0656.
PATRICi 22304771. VBILawInt40445_0716.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci LINT363253:GH6E-679-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
    Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PHE/MN1-00.

Entry informationi

Entry nameiASSY_LAWIP
AccessioniPrimary (citable) accession number: Q1MQL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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