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Protein

5'-nucleotidase SurE

Gene

surE

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Divalent metal cationUniRule annotation1
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi40Divalent metal cationUniRule annotation1
Metal bindingi95Divalent metal cationUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation)
Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:LI0762
OrganismiLawsonia intracellularis (strain PHE/MN1-00)
Taxonomic identifieri363253 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
Proteomesi
  • UP000002430 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000077431 – 2515'-nucleotidase SurEAdd BLAST251

Interactioni

Protein-protein interaction databases

STRINGi363253.LI0762.

Structurei

3D structure databases

ProteinModelPortaliQ1MQB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122501.
KOiK03787.
OMAiAITIAHP.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1MQB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILLTNDDG IHASGLRAIY NELVKLGHNV FPFAPTVERS GASNSVSLNV
60 70 80 90 100
PLTTQDVYDG DFKGTAINGT PVDCVKVGLA KLHENPPDLI ISGINAGHNV
110 120 130 140 150
GTDILYSGTV AAAMEGCVAG IPSIAFSRPR EEVDPTQSYA EHAANLLKKI
160 170 180 190 200
DFSLVPKGQI LNINYPSISI KKTLGIKVCA MSTQGWEHKL HKKKDDNGKP
210 220 230 240 250
YWFISPYIPY SHGISQTDVF FLLEGWITIT PLMFNMTAQT TLSNLEQHSF

T
Length:251
Mass (Da):27,343
Last modified:May 30, 2006 - v1
Checksum:iE472FC9AFC1A1C07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA. Translation: CAJ54816.1.
RefSeqiWP_011526845.1. NC_008011.1.

Genome annotation databases

KEGGilip:LI0762.
PATRICi22305005. VBILawInt40445_0829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA. Translation: CAJ54816.1.
RefSeqiWP_011526845.1. NC_008011.1.

3D structure databases

ProteinModelPortaliQ1MQB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi363253.LI0762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGilip:LI0762.
PATRICi22305005. VBILawInt40445_0829.

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122501.
KOiK03787.
OMAiAITIAHP.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSURE_LAWIP
AccessioniPrimary (citable) accession number: Q1MQB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.