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Q1MQA7

- Q1MQA7_LAWIP

UniProt

Q1MQA7 - Q1MQA7_LAWIP

Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotationSAAS annotation

    Catalytic activityi

    10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLINT363253:GH6E-793-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
    Gene namesi
    Name:fmtUniRule annotationImported
    Ordered Locus Names:LI0766Imported
    OrganismiLawsonia intracellularis (strain PHE/MN1-00)Imported
    Taxonomic identifieri363253 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
    ProteomesiUP000002430: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi363253.LI0766.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1MQA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 1204Tetrahydrofolate (THF) bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Fmt family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0223.
    HOGENOMiHOG000261177.
    KOiK00604.
    OMAiKAQAQNE.
    OrthoDBiEOG6B09WV.

    Family and domain databases

    Gene3Di3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPiMF_00182. Formyl_trans.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1MQA7-1 [UniParc]FASTAAdd to Basket

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    MILQNKPLRI VFMGTPEFAA IILQKIVASG KVDIIASYCQ PDRPVGRGHK    50
    VQFSAVKILS NSLRIPVYQP VNFKSEYEIE KLYALKPDLL VVAAYGLILP 100
    QSVLDIPAIS PLNVHASLLP CYRGAAPIQR ALMNNDKKTG VTIIRMEKGL 150
    DTGAMFTHEE IPINMEDTAA TMHEKLAQLG GKLLINIFEQ IIQGTLSDPT 200
    PQDDIQATYA PKLTKSDGCI YWDMPAENVH AVVRGVTPWP GAQTSFKLVN 250
    RNPINILFQP GEIGSNELFK YNEGDSPLPG SILGLKGNAI AIACKDVPYL 300
    IYTLRPEGRK TMTAKDFWNG YL 322
    Length:322
    Mass (Da):35,502
    Last modified:May 30, 2006 - v1
    Checksum:iE9DB9BE81986FC4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180252 Genomic DNA. Translation: CAJ54820.1.
    RefSeqiWP_011526849.1. NC_008011.1.
    YP_595141.1. NC_008011.1.

    Genome annotation databases

    GeneIDi4059748.
    KEGGilip:LI0766.
    PATRICi22305013. VBILawInt40445_0833.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180252 Genomic DNA. Translation: CAJ54820.1 .
    RefSeqi WP_011526849.1. NC_008011.1.
    YP_595141.1. NC_008011.1.

    3D structure databases

    ProteinModelPortali Q1MQA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 363253.LI0766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4059748.
    KEGGi lip:LI0766.
    PATRICi 22305013. VBILawInt40445_0833.

    Phylogenomic databases

    eggNOGi COG0223.
    HOGENOMi HOG000261177.
    KOi K00604.
    OMAi KAQAQNE.
    OrthoDBi EOG6B09WV.

    Enzyme and pathway databases

    BioCyci LINT363253:GH6E-793-MONOMER.

    Family and domain databases

    Gene3Di 3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPi MF_00182. Formyl_trans.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
      Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PHE/MN1-00Imported.

    Entry informationi

    Entry nameiQ1MQA7_LAWIP
    AccessioniPrimary (citable) accession number: Q1MQA7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3