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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotationSAAS annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processProtein biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLINT363253:G1GJC-848-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotationSAAS annotation (EC:2.1.2.9UniRule annotationSAAS annotation)
Gene namesi
Name:fmtUniRule annotationImported
Ordered Locus Names:LI0766Imported
OrganismiLawsonia intracellularis (strain PHE/MN1-00)Imported
Taxonomic identifieri363253 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
Proteomesi
  • UP000002430 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi363253.LI0766

Structurei

3D structure databases

ProteinModelPortaliQ1MQA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 186Formyl_trans_NInterPro annotationAdd BLAST178
Domaini212 – 321Formyl_trans_CInterPro annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 120Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q1MQA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILQNKPLRI VFMGTPEFAA IILQKIVASG KVDIIASYCQ PDRPVGRGHK
60 70 80 90 100
VQFSAVKILS NSLRIPVYQP VNFKSEYEIE KLYALKPDLL VVAAYGLILP
110 120 130 140 150
QSVLDIPAIS PLNVHASLLP CYRGAAPIQR ALMNNDKKTG VTIIRMEKGL
160 170 180 190 200
DTGAMFTHEE IPINMEDTAA TMHEKLAQLG GKLLINIFEQ IIQGTLSDPT
210 220 230 240 250
PQDDIQATYA PKLTKSDGCI YWDMPAENVH AVVRGVTPWP GAQTSFKLVN
260 270 280 290 300
RNPINILFQP GEIGSNELFK YNEGDSPLPG SILGLKGNAI AIACKDVPYL
310 320
IYTLRPEGRK TMTAKDFWNG YL
Length:322
Mass (Da):35,502
Last modified:May 30, 2006 - v1
Checksum:iE9DB9BE81986FC4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA Translation: CAJ54820.1
RefSeqiWP_011526849.1, NC_008011.1

Genome annotation databases

KEGGilip:LI0766

Similar proteinsi

Entry informationi

Entry nameiQ1MQA7_LAWIP
AccessioniPrimary (citable) accession number: Q1MQA7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health