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Q1MPZ9

- FTHS_LAWIP

UniProt

Q1MPZ9 - FTHS_LAWIP

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 818ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLINT363253:GH6E-906-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LI0874
    OrganismiLawsonia intracellularis (strain PHE/MN1-00)
    Taxonomic identifieri363253 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
    ProteomesiUP000002430: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Formate--tetrahydrofolate ligasePRO_0000293044Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi363253.LI0874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1MPZ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1MPZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSPLNYAD WEIAQAAEKH MKTVYDLGKD LGLDHKEIFP YGHYMGKVDY    50
    KSVLSRLEQS SDGKYIDVTA ITPTPLGEGK STTTIGLVQG LAKRGKRSSA 100
    AIRQPSGGPT MGVKGSAAGG GLSQCIPLTQ YSLGFTGDIN AVMNAHNLSM 150
    VALTSRMQHE RNYSDEKLYA LSNMKRLDID PTNIPMGWVM DFCCQSLRNI 200
    IIGIDGVSGK SDGYMMRSHF DIAVSSEVMA ILAIAKDLKD FRQRISKIIV 250
    AYDKQGKAIT TADLEVDGAM TAWMVEAINP NLIQSIEGQP IFVHAGPFAN 300
    IAIGQSSVIA DRLGLKLSEY HVTESGFGVD IGYEKFWNLK CHYSGLTPDA 350
    AVIVTTVRAL KSHGGAPIPI PGRPLPKEYT EENVGYVEVG SANLIHHINT 400
    VKKSGVPPVV CINAFTTDTP SEIAKIRQLC ELVGARVAVS KHWEYGGDGA 450
    LELADAVIDA CNEEKNFLPL YDWSLPLKER IEKIAFEVYG AEGVEFSEEA 500
    IYKLNKLQAD NNSSDLGVCM VKTHLSLSDD PKQKGVPDHW KLHVRDIMFF 550
    GGAGFVVPIA GSITLMPGTG SNPSFRRIDV DTDTGKVKGI F 591
    Length:591
    Mass (Da):64,251
    Last modified:May 30, 2006 - v1
    Checksum:iC08387A37F820458
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180252 Genomic DNA. Translation: CAJ54928.1.
    RefSeqiYP_595249.1. NC_008011.1.

    Genome annotation databases

    GeneIDi4059356.
    KEGGilip:LI0874.
    PATRICi22305255. VBILawInt40445_0949.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180252 Genomic DNA. Translation: CAJ54928.1 .
    RefSeqi YP_595249.1. NC_008011.1.

    3D structure databases

    ProteinModelPortali Q1MPZ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 363253.LI0874.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4059356.
    KEGGi lip:LI0874.
    PATRICi 22305255. VBILawInt40445_0949.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LINT363253:GH6E-906-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
      Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PHE/MN1-00.

    Entry informationi

    Entry nameiFTHS_LAWIP
    AccessioniPrimary (citable) accession number: Q1MPZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3