Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1MPZ9

- FTHS_LAWIP

UniProt

Q1MPZ9 - FTHS_LAWIP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 818ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLINT363253:GH6E-906-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LI0874
OrganismiLawsonia intracellularis (strain PHE/MN1-00)
Taxonomic identifieri363253 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
ProteomesiUP000002430: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Formate--tetrahydrofolate ligasePRO_0000293044Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi363253.LI0874.

Structurei

3D structure databases

ProteinModelPortaliQ1MPZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1MPZ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSPLNYAD WEIAQAAEKH MKTVYDLGKD LGLDHKEIFP YGHYMGKVDY
60 70 80 90 100
KSVLSRLEQS SDGKYIDVTA ITPTPLGEGK STTTIGLVQG LAKRGKRSSA
110 120 130 140 150
AIRQPSGGPT MGVKGSAAGG GLSQCIPLTQ YSLGFTGDIN AVMNAHNLSM
160 170 180 190 200
VALTSRMQHE RNYSDEKLYA LSNMKRLDID PTNIPMGWVM DFCCQSLRNI
210 220 230 240 250
IIGIDGVSGK SDGYMMRSHF DIAVSSEVMA ILAIAKDLKD FRQRISKIIV
260 270 280 290 300
AYDKQGKAIT TADLEVDGAM TAWMVEAINP NLIQSIEGQP IFVHAGPFAN
310 320 330 340 350
IAIGQSSVIA DRLGLKLSEY HVTESGFGVD IGYEKFWNLK CHYSGLTPDA
360 370 380 390 400
AVIVTTVRAL KSHGGAPIPI PGRPLPKEYT EENVGYVEVG SANLIHHINT
410 420 430 440 450
VKKSGVPPVV CINAFTTDTP SEIAKIRQLC ELVGARVAVS KHWEYGGDGA
460 470 480 490 500
LELADAVIDA CNEEKNFLPL YDWSLPLKER IEKIAFEVYG AEGVEFSEEA
510 520 530 540 550
IYKLNKLQAD NNSSDLGVCM VKTHLSLSDD PKQKGVPDHW KLHVRDIMFF
560 570 580 590
GGAGFVVPIA GSITLMPGTG SNPSFRRIDV DTDTGKVKGI F
Length:591
Mass (Da):64,251
Last modified:May 30, 2006 - v1
Checksum:iC08387A37F820458
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA. Translation: CAJ54928.1.
RefSeqiWP_011526957.1. NC_008011.1.
YP_595249.1. NC_008011.1.

Genome annotation databases

GeneIDi4059356.
KEGGilip:LI0874.
PATRICi22305255. VBILawInt40445_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA. Translation: CAJ54928.1 .
RefSeqi WP_011526957.1. NC_008011.1.
YP_595249.1. NC_008011.1.

3D structure databases

ProteinModelPortali Q1MPZ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 363253.LI0874.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4059356.
KEGGi lip:LI0874.
PATRICi 22305255. VBILawInt40445_0949.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LINT363253:GH6E-906-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
    Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PHE/MN1-00.

Entry informationi

Entry nameiFTHS_LAWIP
AccessioniPrimary (citable) accession number: Q1MPZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3