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Q1MPZ9

- FTHS_LAWIP

UniProt

Q1MPZ9 - FTHS_LAWIP

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, LI0874
Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 818ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLINT363253:GH6E-906-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:LI0874
OrganismiLawsonia intracellularis (strain PHE/MN1-00)
Taxonomic identifieri363253 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
ProteomesiUP000002430: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000293044Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi363253.LI0874.

Structurei

3D structure databases

ProteinModelPortaliQ1MPZ9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1MPZ9-1 [UniParc]FASTAAdd to Basket

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MSLSPLNYAD WEIAQAAEKH MKTVYDLGKD LGLDHKEIFP YGHYMGKVDY    50
KSVLSRLEQS SDGKYIDVTA ITPTPLGEGK STTTIGLVQG LAKRGKRSSA 100
AIRQPSGGPT MGVKGSAAGG GLSQCIPLTQ YSLGFTGDIN AVMNAHNLSM 150
VALTSRMQHE RNYSDEKLYA LSNMKRLDID PTNIPMGWVM DFCCQSLRNI 200
IIGIDGVSGK SDGYMMRSHF DIAVSSEVMA ILAIAKDLKD FRQRISKIIV 250
AYDKQGKAIT TADLEVDGAM TAWMVEAINP NLIQSIEGQP IFVHAGPFAN 300
IAIGQSSVIA DRLGLKLSEY HVTESGFGVD IGYEKFWNLK CHYSGLTPDA 350
AVIVTTVRAL KSHGGAPIPI PGRPLPKEYT EENVGYVEVG SANLIHHINT 400
VKKSGVPPVV CINAFTTDTP SEIAKIRQLC ELVGARVAVS KHWEYGGDGA 450
LELADAVIDA CNEEKNFLPL YDWSLPLKER IEKIAFEVYG AEGVEFSEEA 500
IYKLNKLQAD NNSSDLGVCM VKTHLSLSDD PKQKGVPDHW KLHVRDIMFF 550
GGAGFVVPIA GSITLMPGTG SNPSFRRIDV DTDTGKVKGI F 591
Length:591
Mass (Da):64,251
Last modified:May 30, 2006 - v1
Checksum:iC08387A37F820458
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180252 Genomic DNA. Translation: CAJ54928.1.
RefSeqiYP_595249.1. NC_008011.1.

Genome annotation databases

GeneIDi4059356.
KEGGilip:LI0874.
PATRICi22305255. VBILawInt40445_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180252 Genomic DNA. Translation: CAJ54928.1 .
RefSeqi YP_595249.1. NC_008011.1.

3D structure databases

ProteinModelPortali Q1MPZ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 363253.LI0874.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4059356.
KEGGi lip:LI0874.
PATRICi 22305255. VBILawInt40445_0949.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LINT363253:GH6E-906-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
    Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PHE/MN1-00.

Entry informationi

Entry nameiFTHS_LAWIP
AccessioniPrimary (citable) accession number: Q1MPZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 30, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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