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Q1MPZ9 (FTHS_LAWIP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LI0874
OrganismLawsonia intracellularis (strain PHE/MN1-00) [Complete proteome] [HAMAP]
Taxonomic identifier363253 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293044

Regions

Nucleotide binding74 – 818ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1MPZ9 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: C08387A37F820458

FASTA59164,251
        10         20         30         40         50         60 
MSLSPLNYAD WEIAQAAEKH MKTVYDLGKD LGLDHKEIFP YGHYMGKVDY KSVLSRLEQS 

        70         80         90        100        110        120 
SDGKYIDVTA ITPTPLGEGK STTTIGLVQG LAKRGKRSSA AIRQPSGGPT MGVKGSAAGG 

       130        140        150        160        170        180 
GLSQCIPLTQ YSLGFTGDIN AVMNAHNLSM VALTSRMQHE RNYSDEKLYA LSNMKRLDID 

       190        200        210        220        230        240 
PTNIPMGWVM DFCCQSLRNI IIGIDGVSGK SDGYMMRSHF DIAVSSEVMA ILAIAKDLKD 

       250        260        270        280        290        300 
FRQRISKIIV AYDKQGKAIT TADLEVDGAM TAWMVEAINP NLIQSIEGQP IFVHAGPFAN 

       310        320        330        340        350        360 
IAIGQSSVIA DRLGLKLSEY HVTESGFGVD IGYEKFWNLK CHYSGLTPDA AVIVTTVRAL 

       370        380        390        400        410        420 
KSHGGAPIPI PGRPLPKEYT EENVGYVEVG SANLIHHINT VKKSGVPPVV CINAFTTDTP 

       430        440        450        460        470        480 
SEIAKIRQLC ELVGARVAVS KHWEYGGDGA LELADAVIDA CNEEKNFLPL YDWSLPLKER 

       490        500        510        520        530        540 
IEKIAFEVYG AEGVEFSEEA IYKLNKLQAD NNSSDLGVCM VKTHLSLSDD PKQKGVPDHW 

       550        560        570        580        590 
KLHVRDIMFF GGAGFVVPIA GSITLMPGTG SNPSFRRIDV DTDTGKVKGI F 

« Hide

References

[1]"The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PHE/MN1-00.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180252 Genomic DNA. Translation: CAJ54928.1.
RefSeqYP_595249.1. NC_008011.1.

3D structure databases

ProteinModelPortalQ1MPZ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING363253.LI0874.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4059356.
KEGGlip:LI0874.
PATRIC22305255. VBILawInt40445_0949.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13507.

Enzyme and pathway databases

BioCycLINT363253:GH6E-906-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LAWIP
AccessionPrimary (citable) accession number: Q1MPZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways