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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciLINT363253:G1GJC-1000-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:LI0906
OrganismiLawsonia intracellularis (strain PHE/MN1-00)
Taxonomic identifieri363253 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
Proteomesi
  • UP000002430 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003009211 – 430Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ1MPW7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi363253.LI0906

Structurei

3D structure databases

ProteinModelPortaliQ1MPW7
SMRiQ1MPW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q1MPW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEESSKELY SKAVKLIPGG VNSPVRACRN VGCEPVFIES AKGAYLTTVD
60 70 80 90 100
GQELLDFVLS WGAIILGHTN STVTNAIKKA ASNGTTFGAP CKAEVLLAKE
110 120 130 140 150
IIDAFPGMDM IRMVSSGTEA TMSALRLARG VTGRNKVLKF IGCYHGHADP
160 170 180 190 200
FLASAGSGVA TLSIPGTPGV PEVTVRDTLL APYNDLSTVK DLFVMYGKDL
210 220 230 240 250
AAVFVEPIAA NMGLIPPKEG FLKGLRALCD AHGTLLIMDE VITGFRVAYG
260 270 280 290 300
GAQTRFDITP DLTTLGKIIG GGLPIGAYGG KAKYMEHIAP LGEIYQAGTL
310 320 330 340 350
SGNPLVMTAG FETLQLLKDI NYTILEKQVA TFANELEVIL KDKGVPVQVS
360 370 380 390 400
NFASMFTVFF TNNELKSFDD VKTTNTQLYS ILFRSMQKNN IFLVPSPFET
410 420 430
NMVSFAHKEK EFEKALIAAK KIMFNITDVN
Length:430
Mass (Da):46,290
Last modified:May 30, 2006 - v1
Checksum:i148318A952B9F98A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA Translation: CAJ54960.1
RefSeqiWP_011526989.1, NC_008011.1

Genome annotation databases

KEGGilip:LI0906

Similar proteinsi

Entry informationi

Entry nameiGSA_LAWIP
AccessioniPrimary (citable) accession number: Q1MPW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 30, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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