Q1MNF4 (Q1MNF4_RHIL3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 1 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE1 HAMAP MF_00222
Ordered Locus Names:	RL0003

Organism

Rhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]

Taxonomic identifier

216596 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 SAAS SAAS011342
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 SAAS SAAS011342
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222 SAAS SAAS011342
Ligand	NADP HAMAP MF_00222 SAAS SAAS011342
Molecular function	Oxidoreductase RuleBase RU004037 HAMAP MF_00222 SAAS SAAS011342
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	136 – 140	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	75	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q1MNF4 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 5B3C5B649D61E3F4	FASTA	285	30,796
	10 20 30 40 50 60 MGDSRETFGP KAFVTGFPIK HSRSPLIHGY WLKTLGLLGS YRAHEVTPEA FADFIHSLKD 70 80 90 100 110 120 GSSGFTGGNV TIPHKELAFR LADKPDALSQ ELGASNTLWR EDGALHATNT DGRGFIANLD 130 140 150 160 170 180 ERHPGWDRHG TAVVFGAGGA SRAIIQAVRD RGFKEIHVVN RTVERARELA DRFGPRVQAH 190 200 210 220 230 240 PAGALVEVMK GAGLFINTTS LGMDGEPAPQ LDFSPLAADA VVTDIVYVPL KTPILAQAEE 250 260 270 280 QGFPIVDGLG MLLHQAVPGF EKWFGQRPIV DAPLRALIIA DMEAH

References

[1]

"The genome of Rhizobium leguminosarum has recognizable core and accessory components." Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I., Chillingworth T., Clarke K. , Cronin A., Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J. Genome Biol. 7:R34.1-R34.20(2006) [PubMed: 16640791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM236080 Genomic DNA. Translation: CAK05491.1.
RefSeq	YP_765607.1. NC_008380.1.
3D structure databases
ProteinModelPortal	Q1MNF4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1MNF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4402475.
GenomeReviews	Gene locus RL0003 in contig AM236080_GR.
KEGG	rle:RL0003.
NMPDR	fig|216596.1.peg.14.
PATRIC	23136337. VBIRhiLeg32091_1129.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	CKNEDLE.
PhylomeDB	Q1MNF4.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	RLEG216596:RL0003-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1MNF4_RHIL3

Accession

Primary (citable) accession number: Q1MNF4

Entry history

Integrated into UniProtKB/TrEMBL:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)