Q1MKH7 (KHSE_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	RL1031

Organism

Rhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]

Taxonomic identifier

216596 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_0000300802

Sequences

	Sequence		Length	Mass (Da)
	Q1MKH7 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: BD7D5F4585181F22	FASTA	321	35,799
	10 20 30 40 50 60 MAVYTDIAED DLKWFLTEYD AGTLLSYKGI AEGVENSNFL LHTSKDPLIL TLYEKRVEKS 70 80 90 100 110 120 DLPFFLGLMQ HLSARGLSCP LPLPRRDGAL LGSLSGRPAA LISFLEGMWL RKPEAKHCRE 130 140 150 160 170 180 VGRALAEMHV AGDGFALKRP NALSIDGWRG LWEKSEARAG EVEPGLRDEI RSELDFLSAA 190 200 210 220 230 240 WPSGLPAGVI HADLFPDNVF FLGDQLSGLI DFYFACNDLL AYDVSICLNA WCFEKDGAYN 250 260 270 280 290 300 ITKGTAMLEG YQSVRPLSDA EISALPVLSR GSALRFFLTR LYDWLTTPEG AMVTKKDPLE 310 320 YLRKLRFHRQ IKSPAEYGLS L

References

[1]

"The genome of Rhizobium leguminosarum has recognizable core and accessory components." Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I., Chillingworth T., Clarke K. , Cronin A., Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J. Genome Biol. 7:R34.1-R34.20(2006) [PubMed: 16640791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 3841.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM236080 Genomic DNA. Translation: CAK06528.1.
RefSeq	YP_766642.1. NC_008380.1.
3D structure databases
ProteinModelPortal	Q1MKH7.
SMR	Q1MKH7. Positions 5-320.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1MKH7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4400562.
GenomeReviews	Gene locus RL1031 in contig AM236080_GR.
KEGG	rle:RL1031.
NMPDR	fig|216596.1.peg.1082.
PATRIC	23138505. VBIRhiLeg32091_2197.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	RLEG216596:RL1031-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RHIL3

Accession

Primary (citable) accession number: Q1MKH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 30, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program