ID   BETA_RHIL3              Reviewed;         549 AA.
AC   Q1MJU4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=RL1270;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R.,
RA   Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D.,
RA   Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C.,
RA   Arrowsmith C., Cherevach I., Chillingworth T., Clarke K., Cronin A.,
RA   Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S.,
RA   Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA   Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and
RT   accessory components.";
RL   Genome Biol. 7:RESEARCH34.1-RESEARCH34.20(2006).
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; AM236080; CAK06766.1; -; Genomic_DNA.
DR   RefSeq; YP_766875.1; -.
DR   GeneID; 4399360; -.
DR   GenomeReviews; AM236080_GR; RL1270.
DR   KEGG; rle:RL1270; -.
DR   NMPDR; fig|216596.1.peg.1323; -.
DR   HOGENOM; Q1MJU4; -.
DR   OMA; Q1MJU4; DMGIAVK.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    549       Choline dehydrogenase.
FT                                /FTId=PRO_0000258933.
FT   NP_BIND       4     33       FAD (Probable).
FT   ACT_SITE    465    465       By similarity.
SQ   SEQUENCE   549 AA;  60299 MW;  BC54B99E2B9A6912 CRC64;
     MQADFVIIGS GSAGSALAYR LSEGGKNSVI VIEAGGSDFG PFIQMPAALA WPMSMKRYNW
     GYLSEPEANL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE DFNRWEELGA SGWAYADVLP
     YFKRMEHSHG GEEGWRGTDG PLHVQRGGFT NPLFQAFVEA GKQAGFETTE DYNGSKQEGF
     GLMEQTIFGG RRWSAANAYL KPALKRDNVK IVYGLAQRIV IEDGRATGVE IERNGRIEVV
     KANREVIVSA SSFNSPKLLM LSGIGPGQHL QDMGIAVKAD RPGVGANLQD HMEFYFQQVS
     TKPVSLYSWL PWFWQGVAGA QWLLSRGGLG ASNQFEACAF LRSAPGLKQP DIQYHFLPVA
     ISYDGKAAAK SHGFQVHVGY NLSKSRGSVS LRSADPKADP VLRFNYMSHA EDWEKFRHCV
     RLTREIFGQS AFHDYRGPEI QPGEGVQSDE EIDAFLREHL ESAYHPCGTC RMGAKDDPMA
     VVDPQTRVIG IDGLRVADSS IFPHVTYGNL NGPSIMTGEK AADHILGKQP LARSNQEPWI
     NPRAAVSDR
//