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Q1MJU4

- BETA_RHIL3

UniProt

Q1MJU4 - BETA_RHIL3

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei465 – 4651UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 3330FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciRLEG216596:GKE5-1301-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:RL1270
    OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
    Taxonomic identifieri216596 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000006575: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_0000258933Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216596.RL1270.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1MJU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiREMHCPR.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1MJU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQADFVIIGS GSAGSALAYR LSEGGKNSVI VIEAGGSDFG PFIQMPAALA    50
    WPMSMKRYNW GYLSEPEANL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE 100
    DFNRWEELGA SGWAYADVLP YFKRMEHSHG GEEGWRGTDG PLHVQRGGFT 150
    NPLFQAFVEA GKQAGFETTE DYNGSKQEGF GLMEQTIFGG RRWSAANAYL 200
    KPALKRDNVK IVYGLAQRIV IEDGRATGVE IERNGRIEVV KANREVIVSA 250
    SSFNSPKLLM LSGIGPGQHL QDMGIAVKAD RPGVGANLQD HMEFYFQQVS 300
    TKPVSLYSWL PWFWQGVAGA QWLLSRGGLG ASNQFEACAF LRSAPGLKQP 350
    DIQYHFLPVA ISYDGKAAAK SHGFQVHVGY NLSKSRGSVS LRSADPKADP 400
    VLRFNYMSHA EDWEKFRHCV RLTREIFGQS AFHDYRGPEI QPGEGVQSDE 450
    EIDAFLREHL ESAYHPCGTC RMGAKDDPMA VVDPQTRVIG IDGLRVADSS 500
    IFPHVTYGNL NGPSIMTGEK AADHILGKQP LARSNQEPWI NPRAAVSDR 549
    Length:549
    Mass (Da):60,299
    Last modified:May 30, 2006 - v1
    Checksum:iBC54B99E2B9A6912
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM236080 Genomic DNA. Translation: CAK06766.1.
    RefSeqiYP_766875.1. NC_008380.1.

    Genome annotation databases

    EnsemblBacteriaiCAK06766; CAK06766; RL1270.
    GeneIDi4399360.
    KEGGirle:RL1270.
    PATRICi23139021. VBIRhiLeg32091_2453.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM236080 Genomic DNA. Translation: CAK06766.1 .
    RefSeqi YP_766875.1. NC_008380.1.

    3D structure databases

    ProteinModelPortali Q1MJU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216596.RL1270.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK06766 ; CAK06766 ; RL1270 .
    GeneIDi 4399360.
    KEGGi rle:RL1270.
    PATRICi 23139021. VBIRhiLeg32091_2453.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi REMHCPR.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci RLEG216596:GKE5-1301-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 3841.

    Entry informationi

    Entry nameiBETA_RHIL3
    AccessioniPrimary (citable) accession number: Q1MJU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3