ID   BETB_RHIL3              Reviewed;         487 AA.
AC   Q1MJU3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=RL1271;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R.,
RA   Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D.,
RA   Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C.,
RA   Arrowsmith C., Cherevach I., Chillingworth T., Clarke K., Cronin A.,
RA   Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S.,
RA   Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA   Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and
RT   accessory components.";
RL   Genome Biol. 7:RESEARCH34.1-RESEARCH34.20(2006).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AM236080; CAK06767.1; -; Genomic_DNA.
DR   RefSeq; YP_766876.1; -.
DR   GeneID; 4399361; -.
DR   GenomeReviews; AM236080_GR; RL1271.
DR   KEGG; rle:RL1271; -.
DR   NMPDR; fig|216596.1.peg.1324; -.
DR   HOGENOM; Q1MJU3; -.
DR   OMA; Q1MJU3; VFKPSEN.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR011264; Betaine_Ald_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    487       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_1000047053.
FT   NP_BIND     228    233       NAD (By similarity).
FT   ACT_SITE    250    250       By similarity.
FT   ACT_SITE    284    284       By similarity.
SQ   SEQUENCE   487 AA;  51895 MW;  2A50341B2BD7202B CRC64;
     MKAQPKASHF IDGEYVEDTD GTVIESLYPA TGEVIARLHA ATPAIVERAI AAAKRAQPEW
     AAMSPMARGR ILKRAADIMR ERNRVLSELE TLDTGKPIQE TVVADPTSGA DAFEFFGGIA
     PAGLNGSHIP LGQDFAYTKR VPLGVCVGIG AWNYPQQIAC WKAAPALVCG NAMVFKPSEN
     TPLGALKIAE ILHEAGLPKG LFNVIQGDRD TGPLLVNHPD VAKVSLTGSV PTGRRVAAAA
     AGNLKHVTME LGGKSPLVVF DDADLDSAVG GAMLGNFYST GQVCSNGTRV FVQKTIKDEF
     LKRLKVRTEA MLIGDPMDEA TQVGPMVSWA QREKVISYIE KGKAEGATLI AGGGIPNNVS
     GEGYYVQPTV FADVTDDMTI AREEIFGPVM CVLDFDAEDE VIARANASEF GLSGGVFTAD
     LTRAHRVVDR LEAGTLWINT YNLCPVEIPF GGSKQSGFGR ENSLAALEHY SELKTVYVGM
     GPVVAPY
//