Reviewed, UniProtKB/Swiss-Prot Q1MJU3 (BETB_RHIL3)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	RL1271

Organism

Rhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]

Taxonomic identifier

216596 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_1000047053
Regions
	Nucleotide binding	228 – 233	6	NAD By similarity
Sites
	Active site	250	1	By similarity
	Active site	284	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1MJU3-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 2A50341B2BD7202B	FASTA	487	51,895
	10 20 30 40 50 60 MKAQPKASHF IDGEYVEDTD GTVIESLYPA TGEVIARLHA ATPAIVERAI AAAKRAQPEW 70 80 90 100 110 120 AAMSPMARGR ILKRAADIMR ERNRVLSELE TLDTGKPIQE TVVADPTSGA DAFEFFGGIA 130 140 150 160 170 180 PAGLNGSHIP LGQDFAYTKR VPLGVCVGIG AWNYPQQIAC WKAAPALVCG NAMVFKPSEN 190 200 210 220 230 240 TPLGALKIAE ILHEAGLPKG LFNVIQGDRD TGPLLVNHPD VAKVSLTGSV PTGRRVAAAA 250 260 270 280 290 300 AGNLKHVTME LGGKSPLVVF DDADLDSAVG GAMLGNFYST GQVCSNGTRV FVQKTIKDEF 310 320 330 340 350 360 LKRLKVRTEA MLIGDPMDEA TQVGPMVSWA QREKVISYIE KGKAEGATLI AGGGIPNNVS 370 380 390 400 410 420 GEGYYVQPTV FADVTDDMTI AREEIFGPVM CVLDFDAEDE VIARANASEF GLSGGVFTAD 430 440 450 460 470 480 LTRAHRVVDR LEAGTLWINT YNLCPVEIPF GGSKQSGFGR ENSLAALEHY SELKTVYVGM GPVVAPY

References

[1]

"The genome of Rhizobium leguminosarum has recognizable core and accessory components." Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I., Chillingworth T., Clarke K. , Cronin A., Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J. Genome Biol. 7:RESEARCH34.1-RESEARCH34.20(2006) [PubMed: 16640791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM236080 Genomic DNA. Translation: CAK06767.1.
RefSeq	YP_766876.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4399361.
GenomeReviews	Gene locus RL1271 in contig AM236080_GR.
KEGG	rle:RL1271.
NMPDR	fig|216596.1.peg.1324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1MJU3.
OMA	Q1MJU3. VFKPSEN.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_RHIL3

Accession

Primary (citable) accession number: Q1MJU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 30, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)