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Q1MJU3 (BETB_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase

Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:RL1271
OrganismRhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]
Taxonomic identifier216596 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity. HAMAP-Rule MF_00804

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Cofactor

Binds 2 potassium ions per subunit By similarity. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Subunit structure

Dimer of dimers By similarity. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandMetal-binding
NAD
NADP
Potassium
   Molecular functionOxidoreductase
   PTMOxidation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000047053

Regions

Nucleotide binding150 – 1534NAD/NADP By similarity
Nucleotide binding176 – 1794NAD/NADP By similarity
Nucleotide binding228 – 2336NAD/NADP By similarity

Sites

Active site1621Charge relay system By similarity
Active site2501Proton acceptor By similarity
Active site4611Charge relay system By similarity
Metal binding261Potassium 1 By similarity
Metal binding931Potassium 1 By similarity
Metal binding2441Potassium 2; via carbonyl oxygen By similarity
Metal binding4541Potassium 2; via carbonyl oxygen By similarity
Metal binding4571Potassium 2; via carbonyl oxygen By similarity
Binding site2841NAD/NADP By similarity
Binding site3841NAD/NADP By similarity

Amino acid modifications

Modified residue2841Cysteine sulfenic acid (-SOH) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1MJU3 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 2A50341B2BD7202B

FASTA48751,895
        10         20         30         40         50         60 
MKAQPKASHF IDGEYVEDTD GTVIESLYPA TGEVIARLHA ATPAIVERAI AAAKRAQPEW 

        70         80         90        100        110        120 
AAMSPMARGR ILKRAADIMR ERNRVLSELE TLDTGKPIQE TVVADPTSGA DAFEFFGGIA 

       130        140        150        160        170        180 
PAGLNGSHIP LGQDFAYTKR VPLGVCVGIG AWNYPQQIAC WKAAPALVCG NAMVFKPSEN 

       190        200        210        220        230        240 
TPLGALKIAE ILHEAGLPKG LFNVIQGDRD TGPLLVNHPD VAKVSLTGSV PTGRRVAAAA 

       250        260        270        280        290        300 
AGNLKHVTME LGGKSPLVVF DDADLDSAVG GAMLGNFYST GQVCSNGTRV FVQKTIKDEF 

       310        320        330        340        350        360 
LKRLKVRTEA MLIGDPMDEA TQVGPMVSWA QREKVISYIE KGKAEGATLI AGGGIPNNVS 

       370        380        390        400        410        420 
GEGYYVQPTV FADVTDDMTI AREEIFGPVM CVLDFDAEDE VIARANASEF GLSGGVFTAD 

       430        440        450        460        470        480 
LTRAHRVVDR LEAGTLWINT YNLCPVEIPF GGSKQSGFGR ENSLAALEHY SELKTVYVGM 


GPVVAPY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM236080 Genomic DNA. Translation: CAK06767.1.
RefSeqYP_766876.1. NC_008380.1.

3D structure databases

ProteinModelPortalQ1MJU3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216596.RL1271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK06767; CAK06767; RL1271.
GeneID4399361.
KEGGrle:RL1271.
PATRIC23139025. VBIRhiLeg32091_2455.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMACTDEMTI.
OrthoDBEOG6BS8QW.

Enzyme and pathway databases

BioCycRLEG216596:GKE5-1302-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_RHIL3
AccessionPrimary (citable) accession number: Q1MJU3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways