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Q1MIS6 (FABH_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:RL1639
OrganismRhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]
Taxonomic identifier216596 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm By similarity HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3233233-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_1000187891

Regions

Region251 – 2555ACP-binding By similarity

Sites

Active site1131 By similarity
Active site2501 By similarity
Active site2801 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1MIS6 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: AF4E2311580BFED8

FASTA32334,148
        10         20         30         40         50         60 
MIRSVVRGFG AALPKRVMTN RDMEAIVDTS DEWIVQRTGI RQRYVAGDDE TTASLGEAAA 

        70         80         90        100        110        120 
RAALANGGLT PADIDLVICA TSTPDNTFPA TSVNIQNRLG MSHGFAFDVQ AVCTGFVYAV 

       130        140        150        160        170        180 
TTADAYIRGG LAKRVLVIGA ETFSRILDWN DRTTCVLFGD GAGAIILEAT EGEGTVADRG 

       190        200        210        220        230        240 
VLTAHLRSDG SHKEKLYVDG GPSTTGTVGK LRMEGREVFK YAVGMITDVI QAAFDSTGTT 

       250        260        270        280        290        300 
ADDLDWLVPH QANRRIIDGS AKKLNIDAAK VVITVDLHGN TSAASIPLAL ATAAGDGRIK 

       310        320 
KGDLVMLEAM GGGFTWGAVL LRW

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM236080 Genomic DNA. Translation: CAK07134.1.
RefSeqYP_767243.1. NC_008380.1.

3D structure databases

ProteinModelPortalQ1MIS6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1MIS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4403267.
GenomeReviewsGene locus RL1639 in contig AM236080_GR.
KEGGrle:RL1639.
NMPDRfig|216596.1.peg.1711.
PATRIC23139819. VBIRhiLeg32091_2851.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMADAYIRGG.
PhylomeDBQ1MIS6.
ProtClustDBPRK09352.

Enzyme and pathway databases

BioCycRLEG216596:RL1639-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_RHIL3
AccessionPrimary (citable) accession number: Q1MIS6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 30, 2006
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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