ID   HGD_RHIL3               Reviewed;         453 AA.
AC   Q1MI52;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   05-MAY-2009, entry version 21.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=RL1864;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R.,
RA   Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D.,
RA   Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C.,
RA   Arrowsmith C., Cherevach I., Chillingworth T., Clarke K., Cronin A.,
RA   Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S.,
RA   Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA   Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and
RT   accessory components.";
RL   Genome Biol. 7:RESEARCH34.1-RESEARCH34.20(2006).
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; AM236080; CAK07358.1; -; Genomic_DNA.
DR   RefSeq; YP_767467.1; -.
DR   GeneID; 4402170; -.
DR   GenomeReviews; AM236080_GR; RL1864.
DR   KEGG; rle:RL1864; -.
DR   NMPDR; fig|216596.1.peg.1951; -.
DR   HOGENOM; Q1MI52; -.
DR   OMA; Q1MI52; HRNCMSE.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    453       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000019539.
FT   METAL       349    349       Iron (By similarity).
FT   METAL       355    355       Iron (By similarity).
FT   METAL       385    385       Iron (By similarity).
SQ   SEQUENCE   453 AA;  50888 MW;  F38F46C99C31976C CRC64;
     MDQTSIQTSD GEAATANTLK YMPGFGNDFE TESLPGALPQ GQNSPQKCNY GLYAEQLSGS
     PFTAPRGTNE RSWLYRIRPS VRHTRRFSNA SYPLWKTAPC LDEHSLPLGQ LRWDPIPAPA
     ERLTFLEGVR TITTAGDAAT QVGMSAHAYV FNEDMVDDYF FNADGELLIV PQLGAIRVFT
     EMGIMDVEPL EICLIPRGMM FKILKSGEQT VWRGYICENY GAKFTLPDRG PIGANCLANP
     RDFKTPVAAF EDKETPCRVH VKWCGKFYVT EIGHSPLDVV AWHGNYAPFK YDLRTFSPVG
     AIRFDHPDPS IFSVLTAPSE DAGTANVDFV IFPPRWLVAE HTFRPPWYHR NIMSEFMGLI
     HGQYDAKEEG FVPGGISLHN MMLPHGPDAL AFEKASNTEL KPVKLDHTMA FMFETRYAQQ
     LTKYAAELET LQDNYLECWD GLERKFDGTP GIK
//