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Q1MG62

- GCSP_RHIL3

UniProt

Q1MG62 - GCSP_RHIL3

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRLEG216596:GKE5-2620-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:RL2573
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000006575: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000045600Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi216596.RL2573.

Structurei

3D structure databases

ProteinModelPortaliQ1MG62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1MG62 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPTEFQFT DYQPYDFANR RHIGPSPAEM TDMLKVIGYN SLDGLIDATL
60 70 80 90 100
PPSIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP
110 120 130 140 150
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMICD LTGLDVANAS
160 170 180 190 200
LLDEATAAAE GMAIAERVAK SKAKAFFVDA DCHPQTIALI RTRAEPLGWS
210 220 230 240 250
VIVGNPVTDL DPVDVFGAIF QYPGTHGHVH DFTGLISRLH QTGAIAIVAA
260 270 280 290 300
DILALTLLKS PGEMGADIAV GSSQRFGVPV GYGGPHAAYM SVKDAIKRSM
310 320 330 340 350
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM
360 370 380 390 400
YAVFHGPKGI KAIAQQVHQK AVLMAKGLEK LGYKVEPETF FDTITVDVGH
410 420 430 440 450
MQGLILRAAV AEGVNLRKVG ETKIGMSLDE RTRPATLEAV WRAFGGNFTI
460 470 480 490 500
ADFEPSYRLP KGLLRTSDYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR
510 520 530 540 550
SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPADQALG YREMIDDLIE
560 570 580 590 600
KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGDGH RDVCLIPTSA
610 620 630 640 650
HGTNPASAQM VGMKVVVVKV RENGDIDLDD FRAKAEQHAA NLACCMITYP
660 670 680 690 700
STHGVFEETV KEICDLVHEH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKAHLAPYL PGHPETDGRP GAVSAAAFGS
760 770 780 790 800
ASILPISWSY CLMMGGEGLT QATKVAILNA NYIAARLRGA YDVLYKSETG
810 820 830 840 850
RVAHECIIDT RPLVDSSGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP
860 870 880 890 900
TESETKAELD RFCEAILAIR EEARAIEDGR MDKVNNPLKN APHTVEDLVG
910 920 930 940 950
EWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLI CTCPPVESYA

EAAE
Length:954
Mass (Da):103,995
Last modified:May 30, 2006 - v1
Checksum:iF2F71F4D55C9639F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM236080 Genomic DNA. Translation: CAK08061.1.
RefSeqiWP_011652127.1. NC_008380.1.
YP_768157.1. NC_008380.1.

Genome annotation databases

EnsemblBacteriaiCAK08061; CAK08061; RL2573.
GeneIDi4400331.
KEGGirle:RL2573.
PATRICi23141789. VBIRhiLeg32091_3816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM236080 Genomic DNA. Translation: CAK08061.1 .
RefSeqi WP_011652127.1. NC_008380.1.
YP_768157.1. NC_008380.1.

3D structure databases

ProteinModelPortali Q1MG62.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216596.RL2573.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK08061 ; CAK08061 ; RL2573 .
GeneIDi 4400331.
KEGGi rle:RL2573.
PATRICi 23141789. VBIRhiLeg32091_3816.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RLEG216596:GKE5-2620-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3841.

Entry informationi

Entry nameiGCSP_RHIL3
AccessioniPrimary (citable) accession number: Q1MG62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3