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Q1MG62

- GCSP_RHIL3

UniProt

Q1MG62 - GCSP_RHIL3

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRLEG216596:GKE5-2620-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:RL2573
    OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
    Taxonomic identifieri216596 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000006575: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000045600Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi216596.RL2573.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1MG62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1MG62-1 [UniParc]FASTAAdd to Basket

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    MTTPTEFQFT DYQPYDFANR RHIGPSPAEM TDMLKVIGYN SLDGLIDATL    50
    PPSIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP 100
    VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMICD LTGLDVANAS 150
    LLDEATAAAE GMAIAERVAK SKAKAFFVDA DCHPQTIALI RTRAEPLGWS 200
    VIVGNPVTDL DPVDVFGAIF QYPGTHGHVH DFTGLISRLH QTGAIAIVAA 250
    DILALTLLKS PGEMGADIAV GSSQRFGVPV GYGGPHAAYM SVKDAIKRSM 300
    PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
    YAVFHGPKGI KAIAQQVHQK AVLMAKGLEK LGYKVEPETF FDTITVDVGH 400
    MQGLILRAAV AEGVNLRKVG ETKIGMSLDE RTRPATLEAV WRAFGGNFTI 450
    ADFEPSYRLP KGLLRTSDYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
    SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPADQALG YREMIDDLIE 550
    KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGDGH RDVCLIPTSA 600
    HGTNPASAQM VGMKVVVVKV RENGDIDLDD FRAKAEQHAA NLACCMITYP 650
    STHGVFEETV KEICDLVHEH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKAHLAPYL PGHPETDGRP GAVSAAAFGS 750
    ASILPISWSY CLMMGGEGLT QATKVAILNA NYIAARLRGA YDVLYKSETG 800
    RVAHECIIDT RPLVDSSGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
    TESETKAELD RFCEAILAIR EEARAIEDGR MDKVNNPLKN APHTVEDLVG 900
    EWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLI CTCPPVESYA 950
    EAAE 954
    Length:954
    Mass (Da):103,995
    Last modified:May 30, 2006 - v1
    Checksum:iF2F71F4D55C9639F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM236080 Genomic DNA. Translation: CAK08061.1.
    RefSeqiYP_768157.1. NC_008380.1.

    Genome annotation databases

    EnsemblBacteriaiCAK08061; CAK08061; RL2573.
    GeneIDi4400331.
    KEGGirle:RL2573.
    PATRICi23141789. VBIRhiLeg32091_3816.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM236080 Genomic DNA. Translation: CAK08061.1 .
    RefSeqi YP_768157.1. NC_008380.1.

    3D structure databases

    ProteinModelPortali Q1MG62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216596.RL2573.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK08061 ; CAK08061 ; RL2573 .
    GeneIDi 4400331.
    KEGGi rle:RL2573.
    PATRICi 23141789. VBIRhiLeg32091_3816.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci RLEG216596:GKE5-2620-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 3841.

    Entry informationi

    Entry nameiGCSP_RHIL3
    AccessioniPrimary (citable) accession number: Q1MG62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3