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Q1MG62 (GCSP_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:RL2573
OrganismRhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]
Taxonomic identifier216596 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045600

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1MG62 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: F2F71F4D55C9639F

FASTA954103,995
        10         20         30         40         50         60 
MTTPTEFQFT DYQPYDFANR RHIGPSPAEM TDMLKVIGYN SLDGLIDATL PPSIRQKAPL 

        70         80         90        100        110        120 
VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP VIQRNILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNYQTMICD LTGLDVANAS LLDEATAAAE GMAIAERVAK SKAKAFFVDA 

       190        200        210        220        230        240 
DCHPQTIALI RTRAEPLGWS VIVGNPVTDL DPVDVFGAIF QYPGTHGHVH DFTGLISRLH 

       250        260        270        280        290        300 
QTGAIAIVAA DILALTLLKS PGEMGADIAV GSSQRFGVPV GYGGPHAAYM SVKDAIKRSM 

       310        320        330        340        350        360 
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM YAVFHGPKGI 

       370        380        390        400        410        420 
KAIAQQVHQK AVLMAKGLEK LGYKVEPETF FDTITVDVGH MQGLILRAAV AEGVNLRKVG 

       430        440        450        460        470        480 
ETKIGMSLDE RTRPATLEAV WRAFGGNFTI ADFEPSYRLP KGLLRTSDYL THPIFHMNRA 

       490        500        510        520        530        540 
ESEMTRYIRR LSDRDLALDR SMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPADQALG 

       550        560        570        580        590        600 
YREMIDDLIE KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGDGH RDVCLIPTSA 

       610        620        630        640        650        660 
HGTNPASAQM VGMKVVVVKV RENGDIDLDD FRAKAEQHAA NLACCMITYP STHGVFEETV 

       670        680        690        700        710        720 
KEICDLVHEH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKAHLAPYL PGHPETDGRP GAVSAAAFGS ASILPISWSY CLMMGGEGLT QATKVAILNA 

       790        800        810        820        830        840 
NYIAARLRGA YDVLYKSETG RVAHECIIDT RPLVDSSGVT VDDVAKRLID CGFHAPTMSW 

       850        860        870        880        890        900 
PVAGTLMIEP TESETKAELD RFCEAILAIR EEARAIEDGR MDKVNNPLKN APHTVEDLVG 

       910        920        930        940        950 
EWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLI CTCPPVESYA EAAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM236080 Genomic DNA. Translation: CAK08061.1.
RefSeqYP_768157.1. NC_008380.1.

3D structure databases

ProteinModelPortalQ1MG62.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216596.RL2573.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK08061; CAK08061; RL2573.
GeneID4400331.
KEGGrle:RL2573.
PATRIC23141789. VBIRhiLeg32091_3816.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycRLEG216596:GKE5-2620-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHIL3
AccessionPrimary (citable) accession number: Q1MG62
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families