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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei305Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:RL2781
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000006575 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000216211 – 338Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST338

Proteomic databases

PRIDEiQ1MFK4

Interactioni

Protein-protein interaction databases

STRINGi216596.RL2781

Structurei

3D structure databases

ProteinModelPortaliQ1MFK4
SMRiQ1MFK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUP Bacteria
COG2038 LUCA
HOGENOMiHOG000263500
KOiK00768
OMAiATFGGFE
OrthoDBiPOG091H0031

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.10, 2 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

Q1MFK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSGLPFDD FRTLLRDLPG PDARALVAAR ERDAQLTKPP GALGRLEEIA
60 70 80 90 100
FWLAAWTGRT PAVNRPLVAI FAGNHGVTKQ GITPFPPTVT QQMVENFAAG
110 120 130 140 150
GAAINQICVA YDLGLKVFDL ALDYPTGDIT EEAALSERDC AATMAFGMEA
160 170 180 190 200
IAGGTDLLCI GEMGIGNTTI AAAINYALYG GSARDWVGPG TGSEGEMLER
210 220 230 240 250
KIAAVEKAVA LHGDHLDDPL EIMRRLGGRE IAAMAGAILA ARMERIPVLI
260 270 280 290 300
DGYVATAAAA ILKAANPSAL DHCLIGHVSG EPGHLRAIEM LGKTPLLALG
310 320 330
MRLGEGTGAA LAAGIVKAAA ACHSGMATFA QAGVSNKH
Length:338
Mass (Da):34,956
Last modified:May 30, 2006 - v1
Checksum:i2E4FED78A0EFDB6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM236080 Genomic DNA Translation: CAK08270.1
RefSeqiWP_011652311.1, NC_008380.1

Genome annotation databases

EnsemblBacteriaiCAK08270; CAK08270; RL2781
KEGGirle:RL2781

Similar proteinsi

Entry informationi

Entry nameiCOBT_RHIL3
AccessioniPrimary (citable) accession number: Q1MFK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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