ID   Q1MF33_RHIJ3            Unreviewed;       739 AA.
AC   Q1MF33;
DT   30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   30-MAY-2006, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:CAK08441.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:CAK08441.1};
GN   Name=cyaA6 {ECO:0000313|EMBL:CAK08441.1};
GN   OrderedLocusNames=RL2951 {ECO:0000313|EMBL:CAK08441.1};
OS   Rhizobium johnstonii (strain DSM 114642 / LMG 32736 / 3841) (Rhizobium
OS   leguminosarum bv. viciae).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium;
OC   Rhizobium johnstonii.
OX   NCBI_TaxID=216596 {ECO:0000313|EMBL:CAK08441.1, ECO:0000313|Proteomes:UP000006575};
RN   [1] {ECO:0000313|EMBL:CAK08441.1, ECO:0000313|Proteomes:UP000006575}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3841 {ECO:0000313|EMBL:CAK08441.1,
RC   ECO:0000313|Proteomes:UP000006575};
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F.,
RA   Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H.,
RA   East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach A.,
RA   Chillingworth T., Clarke K., Cronin A., Davis P., Fraser A., Hance Z.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and accessory
RT   components.";
RL   Genome Biol. 7:R34.1-R34.20(2006).
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DR   EMBL; AM236080; CAK08441.1; -; Genomic_DNA.
DR   RefSeq; WP_011652470.1; NC_008380.1.
DR   AlphaFoldDB; Q1MF33; -.
DR   EnsemblBacteria; CAK08441; CAK08441; RL2951.
DR   KEGG; rle:RL2951; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG5616; Bacteria.
DR   HOGENOM; CLU_019981_0_0_5; -.
DR   Proteomes; UP000006575; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.10610; ABC-type transport auxiliary lipoprotein component; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44366; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT; 1.
DR   PANTHER; PTHR44366:SF1; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:CAK08441.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          7..122
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          494..527
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   739 AA;  81485 MW;  E714527DB39F853A CRC64;
     MERRLAAILI ADVVGYSRLS QIDEEGTRAR FQADQNDVFE PAIERHHGRL VKTMGDGLLV
     EFQSVVDALR CAVEVQQLKA TQSAASLPEH RLEFRIGINL GDIIVEGEDI QGDGVNIADR
     IQALAEPGGI AISGTTYDQV KSKIPVGFAS LGEQRLKSIT EPIRVYRILL DPTAAGKTLK
     TRRRLPRRRL VAGIAAAIVV LALAGAALWW QPWMPAKPPG PGERFAYPLP DRPSVAVLPF
     INVSGDSEHD HLAEGLTDDL ITELSKVSGL FVIARHSVFA IQGSVGKIQD VATELGVQYV
     LEGTLQRAGP RLRINVKLID AVSGLSLWAE RYDRQYADLF AVQDDVIGKI ISALSVKLSA
     RERDQLARIP TENLEAYDFY MRAEQEGFIL RDVDTYRRTL SFYQKAIDLD PGFANAHAGI
     ARVAVDVWRN DYNYLWSAAV ARKIAYDAAG QALKLDPNNA RAHTVLALLQ WVDGRETEAK
     NSANMAVAME PNDAEAAANL ALILVHTGSS GQAITEMEKA LRLDPSPASS FQLLAGIVFY
     TAGDDQRAIS LIEPTLDSLP KVEPAREYLA AAYADQGNET KAAAETAKLL ELFPEGNLTY
     YGYLYDYWRD GDLQRHLAAL RKAGIPEWPF GFTGSQADRL GEADLRNLVD GKSWTGKHKN
     GTDFTQYFDR AGNTAYRSAN TNITGIVEVR GDSLCEKFEG YFLDRMVCGY VYRNTSGEQR
     DRPYVHVTPR ALTFFSPTP
//