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Q1MEZ8

- ASSY1_RHIL3

UniProt

Q1MEZ8 - ASSY1_RHIL3

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Protein

Argininosuccinate synthase 1

Gene

argG1

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei88 – 881CitrullineUniRule annotation
Binding sitei93 – 931CitrullineUniRule annotation
Binding sitei118 – 1181ATP; via amide nitrogenUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei124 – 1241AspartateUniRule annotation
Binding sitei124 – 1241CitrullineUniRule annotation
Binding sitei125 – 1251AspartateUniRule annotation
Binding sitei128 – 1281CitrullineUniRule annotation
Binding sitei179 – 1791CitrullineUniRule annotation
Binding sitei188 – 1881CitrullineUniRule annotation
Binding sitei264 – 2641CitrullineUniRule annotation
Binding sitei276 – 2761CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRLEG216596:GKE5-3035-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase 1UniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligase 1UniRule annotation
Gene namesi
Name:argG1UniRule annotation
Ordered Locus Names:RL2987
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000006575: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Argininosuccinate synthase 1PRO_0000263961Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi216596.RL2987.

Structurei

3D structure databases

ProteinModelPortaliQ1MEZ8.
SMRiQ1MEZ8. Positions 6-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiYAFPAIK.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1MEZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKIEKIVLS YSGGLDTSII LKWLQETYGC EVVTFTADLG QGEELEPARA
60 70 80 90 100
KAEMSGVKDI RIVDLREEFV SDFVFPMLRA NALYEGQYLL GSSIARPLIA
110 120 130 140 150
KHLVGIAREV GADAVAHGAT GKGNDQIRFE LAVNALDPSI KVIAPWRQWN
160 170 180 190 200
IRSRLQLSEY AEKHRIPVPS DKRGEAPFSI DANLLHTSTE GKSLENPAEV
210 220 230 240 250
APDHVYQRTV DPVDAPDTPE IITVGFERGD PVSVNGKAMT PAALLTELNG
260 270 280 290 300
LGGRHGVGRL DLVENRFIGM KSRGIYETPG GTILLAAHRG IESITLDRAA
310 320 330 340 350
AHLKDEIMPR YAELIYNGFW FAPEREMLQA LIDHSQAFVS GEVTLRLYKG
360 370 380 390 400
SASVISRASP CSLYSADLVT FEESTIAFDH HDAEGFIRLN GLRLRSWAAR

NGR
Length:403
Mass (Da):44,319
Last modified:May 30, 2006 - v1
Checksum:i4A143B783BBD0634
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM236080 Genomic DNA. Translation: CAK08476.1.
RefSeqiYP_768571.1. NC_008380.1.

Genome annotation databases

EnsemblBacteriaiCAK08476; CAK08476; RL2987.
GeneIDi4400740.
KEGGirle:RL2987.
PATRICi23142673. VBIRhiLeg32091_4258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM236080 Genomic DNA. Translation: CAK08476.1 .
RefSeqi YP_768571.1. NC_008380.1.

3D structure databases

ProteinModelPortali Q1MEZ8.
SMRi Q1MEZ8. Positions 6-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216596.RL2987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK08476 ; CAK08476 ; RL2987 .
GeneIDi 4400740.
KEGGi rle:RL2987.
PATRICi 23142673. VBIRhiLeg32091_4258.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi YAFPAIK.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci RLEG216596:GKE5-3035-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3841.

Entry informationi

Entry nameiASSY1_RHIL3
AccessioniPrimary (citable) accession number: Q1MEZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3