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Q1MDG4

- FTHS_RHIL3

UniProt

Q1MDG4 - FTHS_RHIL3

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRLEG216596:GKE5-3578-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:RL3525
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000006575: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293053Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216596.RL3525.

Structurei

3D structure databases

ProteinModelPortaliQ1MDG4.
SMRiQ1MDG4. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1MDG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSIKSDIEI ARAAAKKPIF EIGAKLGIPV EQLVPYGHDK AKVSAEFIAA
60 70 80 90 100
QAGKKDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAVVCIREAS
110 120 130 140 150
LGPCFGVKGG AAGGGYAQVV PMEDINLHFT GDFHAITSAH NLLAAMIDNH
160 170 180 190 200
IYWGNEENID IRRITWRRVM DMNDRALRSM VLSLGGVANG FPRQGGFDIT
210 220 230 240 250
VASEVMAILC LATDLKDLER RLGDIIIGYR FDRTPVHARD LKADGAMAVL
260 270 280 290 300
LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVTATKT ALKLGDYVVT
310 320 330 340 350
EAGFGADLGA EKFFDIKCRK AGLKPDAAVI VATVRALKMN GGVKKDDLGT
360 370 380 390 400
EDVAALKKGC ANLGRHVANV RRFGVPVVVA INHFVSDTDA EIAAVKEFVS
410 420 430 440 450
RLGAEAILCR HWALGSAGIE DLAHKVVELA ESGQAKFQPL YGDDLSLFEK
460 470 480 490 500
IEIVASKIYH AGEVTADKAV RDQLQTWEEQ GYGKLPICMA KTQYSFSTDP
510 520 530 540 550
NLRGAPEGHI VTVREVRLSA GAGFVVAITG EIMTMPGLPK SPSAERIFLN

DQGYIEGLF
Length:559
Mass (Da):59,778
Last modified:May 30, 2006 - v1
Checksum:iB625A3B13FA014E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM236080 Genomic DNA. Translation: CAK09013.1.
RefSeqiYP_769105.1. NC_008380.1.

Genome annotation databases

EnsemblBacteriaiCAK09013; CAK09013; RL3525.
GeneIDi4403247.
KEGGirle:RL3525.
PATRICi23143803. VBIRhiLeg32091_4821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM236080 Genomic DNA. Translation: CAK09013.1 .
RefSeqi YP_769105.1. NC_008380.1.

3D structure databases

ProteinModelPortali Q1MDG4.
SMRi Q1MDG4. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216596.RL3525.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK09013 ; CAK09013 ; RL3525 .
GeneIDi 4403247.
KEGGi rle:RL3525.
PATRICi 23143803. VBIRhiLeg32091_4821.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RLEG216596:GKE5-3578-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3841.

Entry informationi

Entry nameiFTHS_RHIL3
AccessioniPrimary (citable) accession number: Q1MDG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 30, 2006
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3