Q1MDF7 (Q1MDF7_RHIL3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase HAMAP-Rule MF_00124 RuleBase RU000544
EC=2.7.1.21 HAMAP-Rule MF_00124 RuleBase RU000544

Gene names

Name:	tdk HAMAP-Rule MF_00124 EMBL CAK09020.1
Ordered Locus Names:	RL3532 EMBL CAK09020.1

Organism

Rhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP] EMBL CAK09020.1

Taxonomic identifier

216596 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium › Rhizobium leguminosarum › Rhizobium leguminosarum bv. viciae

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124 SAAS SAAS020634
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00124 SAAS SAAS020634
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00124 SAAS SAAS020634.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP-Rule MF_00124 RuleBase RU004165

Ontologies

Keywords
Biological process	DNA synthesis HAMAP-Rule MF_00124 SAAS SAAS020634 RuleBase RU000544
Cellular component	Cytoplasm HAMAP-Rule MF_00124 SAAS SAAS020634
Ligand	ATP-binding HAMAP-Rule MF_00124 SAAS SAAS020634 RuleBase RU000544 Metal-binding HAMAP-Rule MF_00124 SAAS SAAS020634 Nucleotide-binding Zinc HAMAP-Rule MF_00124 SAAS SAAS020634
Molecular function	Kinase HAMAP-Rule MF_00124 SAAS SAAS020634 RuleBase RU000544 EMBL CAK09020.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-HAMAP thymidine kinase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	9 – 16	8	ATP By similarity HAMAP-Rule MF_00124
	Nucleotide binding	88 – 91	4	ATP By similarity HAMAP-Rule MF_00124
Sites
	Active site	89	1	Proton acceptor By similarity HAMAP-Rule MF_00124
	Metal binding	146	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	148	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	183	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	186	1	Zinc By similarity HAMAP-Rule MF_00124

Sequences

	Sequence		Length	Mass (Da)
	Q1MDF7 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: D0EDF7ADE7013DA1	FASTA	200	22,306
	10 20 30 40 50 60 MAKLYFNYST MNAGKSTMLL QASYNYQERG MRTVQLIAAF DERAGRGVIG SRIGLEASAI 70 80 90 100 110 120 PFEPHEDLFR LVATLSGEGA PISCIFVDEA HFMTPVHVWQ LARVVDRLGI PVMVYGLRTD 130 140 150 160 170 180 FQGKLFPASQ ELLAIADEMR EVRTICHCGR KATMVVRLDA EGKVLHEGAQ IDVGGNEKYV 190 200 SLCRRHWDDA MNGTWIAEPV

References

[1]

"The genome of Rhizobium leguminosarum has recognizable core and accessory components." Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I., Chillingworth T., Clarke K. , Cronin A., Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J. Genome Biol. 7:R34.1-R34.20(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 3841 EMBL CAK09020.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM236080 Genomic DNA. Translation: CAK09020.1.
RefSeq	YP_769112.1. NC_008380.1.
3D structure databases
ProteinModelPortal	Q1MDF7.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	216596.RL3532.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAK09020; CAK09020; RL3532.
GeneID	4400557.
KEGG	rle:RL3532.
PATRIC	23143817. VBIRhiLeg32091_4828.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HOG000076391.
KO	K00857.
OMA	HYSTMNA.
OrthoDB	EOG69D3J2.
Enzyme and pathway databases
BioCyc	RLEG216596:GKE5-3585-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1MDF7_RHIL3

Accession

Primary (citable) accession number: Q1MDF7

Entry history

Integrated into UniProtKB/TrEMBL:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)