Q1MDE8 (ADEC1_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase 1
Short name=Adenase 1
Short name=Adenine aminase 1
EC=3.5.4.2

Gene names

Name:	ade1
Ordered Locus Names:	RL3541

Organism

Rhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]

Taxonomic identifier

216596 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity. HAMAP MF_01518
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 569	569	Adenine deaminase 1 HAMAP MF_01518		PRO_0000292394

Sequences

	Sequence		Length	Mass (Da)
	Q1MDE8 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 7078051D6BA25993	FASTA	569	61,076
	10 20 30 40 50 60 MSNAMTSKLE RFIDQGVGRV PADIVLKGGC FFDLVTGELV QSDIAIGADR IVGTSGNYEG 70 80 90 100 110 120 ETEIDISGRI VVPGFIDTHL HIESSLVTPH EFDRCVLPYG VTTAICDPHE IANVLGAAGI 130 140 150 160 170 180 EFFLESALET IMDIRVQLSS CVPATHLETS GADLPIESLL PYRHHPKVIG LAEFMNFPGV 190 200 210 220 230 240 IHKDPICMAK LDAFQGGHID GHAPLLSGND LNGYLAAGIR TEHECTTASE ALEKIRKGVH 250 260 270 280 290 300 ILVREGSVSK DLAALMPIIT ERLSPFLALC TDDRNPLDIA EQGHLDHMIR TAIASRVEPL 310 320 330 340 350 360 AIYRAASISA ARAFGLKDRG LVAPGWRADL VVLDSLENCR ADMVFSAGRR VTDALFSSRR 370 380 390 400 410 420 PVAPIGLDSV KARPVNAAHF GVPVAEGETP VIGVIPGKII TEHRRYRLPV RGNEAAVDLA 430 440 450 460 470 480 NDIIKVAVIE RHGKNGNHAN GFVQGFGLKK GAIASTVGHD SHNICVVGVS EDDMARAANR 490 500 510 520 530 540 LSEIKGGFVV VEDGKVTGEI ALPIAGLMSL EPYETVRDTL HQLRKAAFAL GATLEEPFLQ 550 560 LAFLPLPVIP HLKISDRGMV DVDKFALIG

References

[1]

"The genome of Rhizobium leguminosarum has recognizable core and accessory components." Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I., Chillingworth T., Clarke K. , Cronin A., Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J. Genome Biol. 7:R34.1-R34.20(2006) [PubMed: 16640791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 3841.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM236080 Genomic DNA. Translation: CAK09029.1.
RefSeq	YP_769121.1. NC_008380.1.
3D structure databases
ProteinModelPortal	Q1MDE8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1MDE8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4401837.
GenomeReviews	Gene locus RL3541 in contig AM236080_GR.
KEGG	rle:RL3541.
NMPDR	fig|216596.1.peg.3658.
PATRIC	23143837. VBIRhiLeg32091_4838.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1001.
HOGENOM	HBG725357.
OMA	GKIITEH.
PhylomeDB	Q1MDE8.
ProtClustDB	CLSK881576.
Enzyme and pathway databases
BioCyc	RLEG216596:RL3541-MONOMER.
Family and domain databases
HAMAP	MF_01518. Adenine_deamin. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01486.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01178. Ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC1_RHIL3

Accession

Primary (citable) accession number: Q1MDE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	May 30, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program