Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q1MBW8 (HEMH_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:RL4076
OrganismRhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]
Taxonomic identifier216596 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Ferrochelatase HAMAP MF_00323
PRO_1000019359

Sites

Metal binding2141Iron By similarity
Metal binding2951Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1MBW8 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: F9F6C9187F96F0C4

FASTA34439,577
        10         20         30         40         50         60 
MTADISLRPA DHPAVRFGKV GVLLVNLGTP DGTDYTSMRR YLREFLTDRR VIEWSPWKWY 

        70         80         90        100        110        120 
PILFGIVLNT RPQKVGKAYE LIWNKEQNES YLRTYTRNQS ELMAGRLKDL DNVKVDWAMR 

       130        140        150        160        170        180 
YGTPSIGSRI DALKEEGCDR IVLFPLYPQY AAATTATVND KAFQKLLSMR WQPALRTVPA 

       190        200        210        220        230        240 
YHDDETYIEA LAASVERHLS TLDWKPEMLL ASFHGIPMSY FKQGDPYYCQ CQKTGRLLRE 

       250        260        270        280        290        300 
RLGLTKENFL VTFQSRFGPE EWLQPYTDKT VEKLAKDGVK RIAVINPGFV SDCLETLEEI 

       310        320        330        340 
AEQAAHSFHE NGGEKFAHIP CLNDGEDGMK VLEKVVRREL QGWV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM236080 Genomic DNA. Translation: CAK09565.1.
RefSeqYP_769651.1. NC_008380.1.

3D structure databases

ProteinModelPortalQ1MBW8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1MBW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4402324.
GenomeReviewsGene locus RL4076 in contig AM236080_GR.
KEGGrle:RL4076.
NMPDRfig|216596.1.peg.4210.
PATRIC23144965. VBIRhiLeg32091_5394.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
PhylomeDBQ1MBW8.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycRLEG216596:RL4076-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_RHIL3
AccessionPrimary (citable) accession number: Q1MBW8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents