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Q1MA74 (PROA_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase
Gene names
Name:proA
Ordered Locus Names:RL4683
OrganismRhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]
Taxonomic identifier216596 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412

Subcellular location

Cytoplasm By similarity HAMAP MF_00412.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glutamate-5-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Gamma-glutamyl phosphate reductase HAMAP MF_00412
PRO_0000252585

Sequences

Sequence LengthMass (Da)Tools
Q1MA74 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 4A86693443F68A9B

FASTA42744,730
        10         20         30         40         50         60 
MLDTVAPGPD IDVLMNDIGR KAKAAARPLG FASTEAKNSA LNAMADAILA NKAHILAENA 

        70         80         90        100        110        120 
KDLKDIEGTE MLASFVDRLT LNDKRVAEMA EGIRAIAALA DPVGEVIAAW DRPNGLKIER 

       130        140        150        160        170        180 
VRTPLGVIGV IFESRPNVTA DAGALCLKAG NAVILRCGSD SRRSSQAIHA CLVKGLKAAG 

       190        200        210        220        230        240 
LPEHAIQLVP VTDRAAVGAM LRGLDGAIDV IVPRGGKSLV ARVQSEARVP VFAHLEGLCH 

       250        260        270        280        290        300 
IYVDASADIE MAKKIIVNAK MRRTGICGAV ETLLVDGAAI GTHLTPLLEA LTDAGCEIRA 

       310        320        330        340        350        360 
SPTVLKVAPG MKPATEEDWS TEYLDAIISV AVVDGISGAI AHIQTYSSNH TEAVIAEDPD 

       370        380        390        400        410        420 
VVARFFTEVD SAILLHNAST QFADGGEFGM GAEIGIATGK MHARGPVGVE QLTSFKYRVH 


GAGQTRP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM236080 Genomic DNA. Translation: CAK10166.1.
RefSeqYP_770245.1. NC_008380.1.

3D structure databases

ProteinModelPortalQ1MA74.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1MA74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4400351.
GenomeReviewsGene locus RL4683 in contig AM236080_GR.
KEGGrle:RL4683.
NMPDRfig|216596.1.peg.4820.
PATRIC23146258. VBIRhiLeg32091_6028.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0014.
HOGENOMHBG318080.
OMAYGICGAM.
PhylomeDBQ1MA74.
ProtClustDBPRK00197.

Enzyme and pathway databases

BioCycRLEG216596:RL4683-MONOMER.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROA_RHIL3
AccessionPrimary (citable) accession number: Q1MA74
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 30, 2006
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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