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Q1MA35

- PUR9_RHIL3

UniProt

Q1MA35 - PUR9_RHIL3

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, RL4722
Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciRLEG216596:GKE5-4799-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:RL4722
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000006575: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000018948Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216596.RL4722.

Structurei

3D structure databases

ProteinModelPortaliQ1MA35.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1MA35-1 [UniParc]FASTAAdd to Basket

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MAVISKKIPA PDKVEIKTAL ISVFDKTGIV DLARALSARG VRLLSTGGTF    50
KAITAAGLAV TDVSEITGFP EIMDGRVKTL HPTVHGGLLA IRDDSEHQDA 100
MKQHGIEGID LAVINLYPFE EVRAAGGDYP TTVENIDIGG PAMIRASAKN 150
HAYVTTLTDP ADYAELLEQL SADDGKTAYT FRQRMAAKAY ARTAAYDAMI 200
SNWFAETLSI DTPRHRVIGG ALKEEMRYGE NPHQKAAFYV TGEKRPGVST 250
AALLQGKQLS YNNINDTDAA YELVAEFLPE KAPACAIIKH ANPCGVATGS 300
SLVEAYRRAL ACDSVSAFGG IIALNQTLDA ETAEEIVKLF TEVIIAPDVT 350
EEAKAIVARK PNLRLLSAGG LPDPRAVGLT AKTVSGGLLV QSRDNGMVED 400
LELKVVTRRA PTAQELDDMK FAFKVGKHVK SNAVVYAKDG QTAGIGAGQM 450
SRVDSARIAA LKAEEAAKAL GLAVPMTHGS AVASEAFLPF ADGLLSMIAA 500
GATAVIQPGG SMRDQEVIDA ANEHGVAMVF TGMRHFRH 538
Length:538
Mass (Da):57,038
Last modified:May 30, 2006 - v1
Checksum:iE56EC6DEE0223280
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM236080 Genomic DNA. Translation: CAK10205.1.
RefSeqiWP_011654051.1. NC_008380.1.
YP_770284.1. NC_008380.1.

Genome annotation databases

EnsemblBacteriaiCAK10205; CAK10205; RL4722.
GeneIDi4399230.
KEGGirle:RL4722.
PATRICi23146340. VBIRhiLeg32091_6069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM236080 Genomic DNA. Translation: CAK10205.1 .
RefSeqi WP_011654051.1. NC_008380.1.
YP_770284.1. NC_008380.1.

3D structure databases

ProteinModelPortali Q1MA35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216596.RL4722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK10205 ; CAK10205 ; RL4722 .
GeneIDi 4399230.
KEGGi rle:RL4722.
PATRICi 23146340. VBIRhiLeg32091_6069.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci RLEG216596:GKE5-4799-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3841.

Entry informationi

Entry nameiPUR9_RHIL3
AccessioniPrimary (citable) accession number: Q1MA35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 30, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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