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Q1MA25 (SYL2_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase 2

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase 2
Short name=LeuRS 2
Gene names
Name:leuS2
Ordered Locus Names:RL4732
OrganismRhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]
Taxonomic identifier216596 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length876 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 876876Leucine--tRNA ligase 2 HAMAP-Rule MF_00049
PRO_0000334803

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif632 – 6365"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6351ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1MA25 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 65A2A38FF62B870A

FASTA87697,967
        10         20         30         40         50         60 
MATERYNPRD AEPRWQQKWN EDKVFETDNA DPREKYYVLE MFPYPSGRIH MGHVRNYAMG 

        70         80         90        100        110        120 
DVVARYKRAR GYNVLHPMGW DAFGMPAENA AMERGVHPAS WTYQNIGSMK AQLKAMGLSL 

       130        140        150        160        170        180 
DWSREFATCD VEYYQHQQHL FLDFLEKGLV YRKQSKVNWD PVDNTVLANE QVIDGRGWRS 

       190        200        210        220        230        240 
GALVEQRELT QWFFKITDFS QDLLDALDTL DQWPEKVRLM QKNWIGRSEG LTIRWEIVPE 

       250        260        270        280        290        300 
TAPAGESEVT VYTTRPDTLF GASFLAIAAD HPLAKDAAAK NPEIEAFCDE CRRAGTSLAA 

       310        320        330        340        350        360 
LETAEKKGMD TGIRVRHPLD PSWELPVYIA NFVLMDYGTG AIFGCPSGDQ RDLDFARKYG 

       370        380        390        400        410        420 
LPVVAVVMPR DGDAASFSVG DTAYDGDGVM INSRFLDGKT TEEAFNIVAD RLSAASLGNA 

       430        440        450        460        470        480 
PQGERKVNFR LRDWGISRQR YWGCPIPVIH CDDCGVVPVP KADLPVKLPD DVTFDQPGNP 

       490        500        510        520        530        540 
LDRHPTWRHV SCPNCGKDAR RETDTMDTFV DSSWYFTRFT APWEDKPTDP EAANRWLPVD 

       550        560        570        580        590        600 
QYIGGIEHAI LHLLYSRFFT RAMRETGHVA ATEPFKGLFT QGMVVHETYS RGAGASREWV 

       610        620        630        640        650        660 
APADIRIDEL DGKRRAFLLT NNEEVSIGSI EKMSKSKKNV VDPDDIIASY GADTARFFVL 

       670        680        690        700        710        720 
SDSPPERDVI WSEAGVEGAH RFTQRLWRLI SEAADALSAV APAPATDGEA LSISQAAHKT 

       730        740        750        760        770        780 
LKAVQNDYDK LWFNKAVARI YELVNALAAP MTKVAAGEGD ATYRAAVRDA AEILIQLVSP 

       790        800        810        820        830        840 
MTPHLAEECW AALGNEGLLA RASWPQYDET LVIENSVVLP VQINGKKRAE LTISRDADQN 

       850        860        870 
TVTDAVLDLD AVKNALNGQA PKKIIVVPQR IVNIVV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM236080 Genomic DNA. Translation: CAK10215.1.
RefSeqYP_770294.1. NC_008380.1.

3D structure databases

ProteinModelPortalQ1MA25.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216596.RL4732.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK10215; CAK10215; RL4732.
GeneID4401000.
KEGGrle:RL4732.
PATRIC23146360. VBIRhiLeg32091_6079.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAPGILNWQ.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycRLEG216596:GKE5-4809-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL2_RHIL3
AccessionPrimary (citable) accession number: Q1MA25
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries