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Q1M5U3 (THIM_RHIL3) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:pRL110443
Encoded onPlasmid pRL11
OrganismRhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]
Taxonomic identifier216596 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383892

Sites

Binding site461Substrate; via amide nitrogen By similarity
Binding site1211ATP By similarity
Binding site1671ATP By similarity
Binding site1941Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1M5U3 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 551189AF02BA9EA2

FASTA26727,292
        10         20         30         40         50         60 
MQTRTTPGAM LKAMREKPPL VQCITNYVAM NIAANVLLAA GASPAMVHAA EEAGEFAAIA 

        70         80         90        100        110        120 
SALTINIGTL STQWIDGMQA AAKAATSAGK PWVLDPVAHY ATAFRRNAVA ELLALKPTII 

       130        140        150        160        170        180 
RGNASEIIAL AGGESRGQGV DSRDPVEQAE GSARWLAERQ RAVVAVTGAV DFVTDGERAV 

       190        200        210        220        230        240 
RIEGGSALMP QVTALGCSLT CLVGAFAATA PEDIFGATVA ALSTFAIAGE EAALGAAGPG 

       250        260 
SFSWRFLDAL AALDAETLDA RARISAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM236085 Genomic DNA. Translation: CAK03396.1.
RefSeqYP_771477.1. NC_008384.1.

3D structure databases

ProteinModelPortalQ1M5U3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216596.pRL110443.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK03396; CAK03396; pRL110443.
GeneID4405073.
KEGGrle:pRL110443.
PATRIC23148795. VBIRhiLeg32091_7294.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMATISESTY.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycRLEG216596:GKE5-6066-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_RHIL3
AccessionPrimary (citable) accession number: Q1M5U3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 30, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways