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Protein

Catalase-peroxidase

Gene

katG

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Transition state stabilizerUniRule annotation1
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi259Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:pRL120362
Encoded oniPlasmid pRL120 Publication
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000006575 Componenti: Plasmid pRL12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_000035488517 – 726Catalase-peroxidaseAdd BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki96 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ1M498

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1M498
SMRiQ1M498
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1M498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNPTDSAGK CPVAHGNTPR SRSNRDWWPD QLNVQILHQN SGRADPLGQA
60 70 80 90 100
FDYAEEFKKL DLDGLKKDLH ALMTDSQDWW PADFGHYGGL FIRMAWHSAG
110 120 130 140 150
TYRITDGRGG AGAGQQRFAP LNSWPDNVNL DKARRLLWPI KQKYGNRISW
160 170 180 190 200
ADLLILTGNV ALESMGFKTF GFAGGRADVW EPEELYWGPE GTWLGDERYS
210 220 230 240 250
GERGLAEPLG AVQMGLIYVN PEGPNGTPDP LASARDIRET FARMAMNDEE
260 270 280 290 300
TVALIAGGHT FGKTHGAGDP SFVGVDPEGG ELEAQGLGWT SKFNTGVGRD
310 320 330 340 350
AIGSGLEVTW TQTPTQWSNY FFENLFAFEW ELTKSPGGAH QWQAKNADAS
360 370 380 390 400
IPDAYDASKR HLPTMLTSDL ALRFDPVYEK ISRRFLENPD QFADAFARAW
410 420 430 440 450
FKLTHRDMGP KVRYLGPEVP AEDLIWQDVI PAVDHPLVDD KDIADLKEKV
460 470 480 490 500
LATGLTVQEL VSTAWASAST FRGSDKRGGA NGARIRLAPQ KDWEVNQPAQ
510 520 530 540 550
LAKVLGVLEG IQKNFNAAQT GAKKISLADL IVLGGAAGVE KAAAAGGHAV
560 570 580 590 600
SVPFTPGRMD ASEAQTDAHS FAALKPRADG FRNYIGGRQF MKPEEALVDR
610 620 630 640 650
AQLLTLTGPE MTVLVGGLRV LKAGAPEHGV FTSRPETLTN DFFVNLLDMG
660 670 680 690 700
TQWSPAAGRD GVYEGRDRKT NDVKWTGTRV DLIFGSHSQL RAFAEVYGQA
710 720
DTKEKFVRDF VAAWTKVMNA DRFDLV
Length:726
Mass (Da):79,667
Last modified:May 30, 2006 - v1
Checksum:i8FE32360D1A334A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM236086 Genomic DNA Translation: CAK12074.1
RefSeqiWP_011649134.1, NC_008378.1

Genome annotation databases

EnsemblBacteriaiCAK12074; CAK12074; pRL120362
KEGGirle:pRL120362

Similar proteinsi

Entry informationi

Entry nameiKATG_RHIL3
AccessioniPrimary (citable) accession number: Q1M498
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 30, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

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