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Protein

UDP-glucuronosyltransferase 3A1

Gene

UGT3A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: GO_Central

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. flavonoid biosynthetic process Source: GO_Central
  3. flavonoid glucuronidation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
Short name:
UDPGT 3A1
Gene namesi
Name:UGT3A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 483461ExtracellularSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Topological domaini505 – 52319CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 523501UDP-glucuronosyltransferase 3A1PRO_0000299149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ1LZI1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003497.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ1LZI1.
OMAiDLVIVEM.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LZI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQQALLLF GFILPGLLFS EAAKILTVSL VGGSHFLLMH QISQILQDHG
60 70 80 90 100
HNVTMLLQKG NLLLPGFKEE EKSYKVFNWF LPEDCNEEFK RSFHSFMEKT
110 120 130 140 150
FGGRCKFEHF LNIMELLGHH CSHLLRRKDV MKSLKNENFD LVIVEMFDYC
160 170 180 190 200
PFLVAEKLGK PFVAILPSAL GTVDFGLPSP LSYVPVFYSL LTDQMDFWGR
210 220 230 240 250
VKNFLMFFEF FKKQWKIQSA YDDTIKEHFP DDSRPVLSHL LTKAELWFVN
260 270 280 290 300
TDFAFDFARP LLPNTVCIGG LMSKPVKPVP QEFENFITKF GDSGFVLVSL
310 320 330 340 350
GSMVSFIRSQ EVLKEMNAAF AHLPQGVIWK YNPSHWPKDI KLAPNVKIVH
360 370 380 390 400
WLPQNDLLGH PRIRLFVSHG GMNSIMEAIQ HGVPMVGIPL FGDQHENLLR
410 420 430 440 450
VKAKKFGVSI QLKQIKAETL ALKMKQVIED KRYKSAAEAA SIIRRSQPLT
460 470 480 490 500
PAQRLVGWIN HILQTGGAAH LKPHAFQQPW YEQYLLDVFL FLLVVTLGTM
510 520
WLCGKLLGLV ARWLCGARKL KKA
Length:523
Mass (Da):59,682
Last modified:May 30, 2006 - v1
Checksum:iBBD64418540DD647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115988 mRNA. Translation: AAI15989.1.
RefSeqiNP_001069555.1. NM_001076087.1.
UniGeneiBt.17923.

Genome annotation databases

EnsembliENSBTAT00000003497; ENSBTAP00000003497; ENSBTAG00000002701.
GeneIDi537188.
KEGGibta:537188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115988 mRNA. Translation: AAI15989.1.
RefSeqiNP_001069555.1. NM_001076087.1.
UniGeneiBt.17923.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003497.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEiQ1LZI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003497; ENSBTAP00000003497; ENSBTAG00000002701.
GeneIDi537188.
KEGGibta:537188.

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ1LZI1.
OMAiDLVIVEM.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Miscellaneous databases

NextBioi20877083.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiUD3A1_BOVIN
AccessioniPrimary (citable) accession number: Q1LZI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 30, 2006
Last modified: February 4, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.