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Protein

UDP-glucuronosyltransferase 3A1

Gene

UGT3A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
Short name:
UDPGT 3A1
Gene namesi
Name:UGT3A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 483ExtracellularSequence analysisAdd BLAST461
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 523CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029914923 – 523UDP-glucuronosyltransferase 3A1Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ1LZI1.
PRIDEiQ1LZI1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002701.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003497.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ1LZI1.
OMAiDLVIVEM.
OrthoDBiEOG091G06JC.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LZI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQQALLLF GFILPGLLFS EAAKILTVSL VGGSHFLLMH QISQILQDHG
60 70 80 90 100
HNVTMLLQKG NLLLPGFKEE EKSYKVFNWF LPEDCNEEFK RSFHSFMEKT
110 120 130 140 150
FGGRCKFEHF LNIMELLGHH CSHLLRRKDV MKSLKNENFD LVIVEMFDYC
160 170 180 190 200
PFLVAEKLGK PFVAILPSAL GTVDFGLPSP LSYVPVFYSL LTDQMDFWGR
210 220 230 240 250
VKNFLMFFEF FKKQWKIQSA YDDTIKEHFP DDSRPVLSHL LTKAELWFVN
260 270 280 290 300
TDFAFDFARP LLPNTVCIGG LMSKPVKPVP QEFENFITKF GDSGFVLVSL
310 320 330 340 350
GSMVSFIRSQ EVLKEMNAAF AHLPQGVIWK YNPSHWPKDI KLAPNVKIVH
360 370 380 390 400
WLPQNDLLGH PRIRLFVSHG GMNSIMEAIQ HGVPMVGIPL FGDQHENLLR
410 420 430 440 450
VKAKKFGVSI QLKQIKAETL ALKMKQVIED KRYKSAAEAA SIIRRSQPLT
460 470 480 490 500
PAQRLVGWIN HILQTGGAAH LKPHAFQQPW YEQYLLDVFL FLLVVTLGTM
510 520
WLCGKLLGLV ARWLCGARKL KKA
Length:523
Mass (Da):59,682
Last modified:May 30, 2006 - v1
Checksum:iBBD64418540DD647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115988 mRNA. Translation: AAI15989.1.
RefSeqiNP_001069555.1. NM_001076087.1.
UniGeneiBt.17923.

Genome annotation databases

EnsembliENSBTAT00000003497; ENSBTAP00000003497; ENSBTAG00000002701.
GeneIDi537188.
KEGGibta:537188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115988 mRNA. Translation: AAI15989.1.
RefSeqiNP_001069555.1. NM_001076087.1.
UniGeneiBt.17923.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003497.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbiQ1LZI1.
PRIDEiQ1LZI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003497; ENSBTAP00000003497; ENSBTAG00000002701.
GeneIDi537188.
KEGGibta:537188.

Organism-specific databases

CTDi167127.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ1LZI1.
OMAiDLVIVEM.
OrthoDBiEOG091G06JC.
TreeFamiTF315472.

Gene expression databases

BgeeiENSBTAG00000002701.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD3A1_BOVIN
AccessioniPrimary (citable) accession number: Q1LZI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.