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Q1LZI1 (UD3A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 3A1

Short name=UDPGT 3A1
EC=2.4.1.17
Gene names
Name:UGT3A1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 523501UDP-glucuronosyltransferase 3A1
PRO_0000299149

Regions

Topological domain23 – 483461Extracellular Potential
Transmembrane484 – 50421Helical; Potential
Topological domain505 – 52319Cytoplasmic Potential

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q1LZI1 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: BBD64418540DD647

FASTA52359,682
        10         20         30         40         50         60 
MAGQQALLLF GFILPGLLFS EAAKILTVSL VGGSHFLLMH QISQILQDHG HNVTMLLQKG 

        70         80         90        100        110        120 
NLLLPGFKEE EKSYKVFNWF LPEDCNEEFK RSFHSFMEKT FGGRCKFEHF LNIMELLGHH 

       130        140        150        160        170        180 
CSHLLRRKDV MKSLKNENFD LVIVEMFDYC PFLVAEKLGK PFVAILPSAL GTVDFGLPSP 

       190        200        210        220        230        240 
LSYVPVFYSL LTDQMDFWGR VKNFLMFFEF FKKQWKIQSA YDDTIKEHFP DDSRPVLSHL 

       250        260        270        280        290        300 
LTKAELWFVN TDFAFDFARP LLPNTVCIGG LMSKPVKPVP QEFENFITKF GDSGFVLVSL 

       310        320        330        340        350        360 
GSMVSFIRSQ EVLKEMNAAF AHLPQGVIWK YNPSHWPKDI KLAPNVKIVH WLPQNDLLGH 

       370        380        390        400        410        420 
PRIRLFVSHG GMNSIMEAIQ HGVPMVGIPL FGDQHENLLR VKAKKFGVSI QLKQIKAETL 

       430        440        450        460        470        480 
ALKMKQVIED KRYKSAAEAA SIIRRSQPLT PAQRLVGWIN HILQTGGAAH LKPHAFQQPW 

       490        500        510        520 
YEQYLLDVFL FLLVVTLGTM WLCGKLLGLV ARWLCGARKL KKA 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC115988 mRNA. Translation: AAI15989.1.
RefSeqNP_001069555.1. NM_001076087.1.
UniGeneBt.17923.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000003497.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEQ1LZI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000003497; ENSBTAP00000003497; ENSBTAG00000002701.
GeneID537188.
KEGGbta:537188.

Phylogenomic databases

eggNOGCOG1819.
GeneTreeENSGT00560000076760.
HOGENOMHOG000220831.
HOVERGENHBG106370.
InParanoidQ1LZI1.
OMAFLNIMEL.
OrthoDBEOG7GBFWS.
TreeFamTF315472.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20877083.

Entry information

Entry nameUD3A1_BOVIN
AccessionPrimary (citable) accession number: Q1LZI1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 30, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families