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Q1LZI1

- UD3A1_BOVIN

UniProt

Q1LZI1 - UD3A1_BOVIN

Protein

UDP-glucuronosyltransferase 3A1

Gene

UGT3A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
    Short name:
    UDPGT 3A1
    Gene namesi
    Name:UGT3A1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 20

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 523501UDP-glucuronosyltransferase 3A1PRO_0000299149Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ1LZI1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000003497.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 483461ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini505 – 52319CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00560000076760.
    HOGENOMiHOG000220831.
    HOVERGENiHBG106370.
    InParanoidiQ1LZI1.
    OMAiIFKEMNN.
    OrthoDBiEOG7GBFWS.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1LZI1-1 [UniParc]FASTAAdd to Basket

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    MAGQQALLLF GFILPGLLFS EAAKILTVSL VGGSHFLLMH QISQILQDHG    50
    HNVTMLLQKG NLLLPGFKEE EKSYKVFNWF LPEDCNEEFK RSFHSFMEKT 100
    FGGRCKFEHF LNIMELLGHH CSHLLRRKDV MKSLKNENFD LVIVEMFDYC 150
    PFLVAEKLGK PFVAILPSAL GTVDFGLPSP LSYVPVFYSL LTDQMDFWGR 200
    VKNFLMFFEF FKKQWKIQSA YDDTIKEHFP DDSRPVLSHL LTKAELWFVN 250
    TDFAFDFARP LLPNTVCIGG LMSKPVKPVP QEFENFITKF GDSGFVLVSL 300
    GSMVSFIRSQ EVLKEMNAAF AHLPQGVIWK YNPSHWPKDI KLAPNVKIVH 350
    WLPQNDLLGH PRIRLFVSHG GMNSIMEAIQ HGVPMVGIPL FGDQHENLLR 400
    VKAKKFGVSI QLKQIKAETL ALKMKQVIED KRYKSAAEAA SIIRRSQPLT 450
    PAQRLVGWIN HILQTGGAAH LKPHAFQQPW YEQYLLDVFL FLLVVTLGTM 500
    WLCGKLLGLV ARWLCGARKL KKA 523
    Length:523
    Mass (Da):59,682
    Last modified:May 30, 2006 - v1
    Checksum:iBBD64418540DD647
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC115988 mRNA. Translation: AAI15989.1.
    RefSeqiNP_001069555.1. NM_001076087.1.
    UniGeneiBt.17923.

    Genome annotation databases

    EnsembliENSBTAT00000003497; ENSBTAP00000003497; ENSBTAG00000002701.
    GeneIDi537188.
    KEGGibta:537188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC115988 mRNA. Translation: AAI15989.1 .
    RefSeqi NP_001069555.1. NM_001076087.1.
    UniGenei Bt.17923.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000003497.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PRIDEi Q1LZI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000003497 ; ENSBTAP00000003497 ; ENSBTAG00000002701 .
    GeneIDi 537188.
    KEGGi bta:537188.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00560000076760.
    HOGENOMi HOG000220831.
    HOVERGENi HBG106370.
    InParanoidi Q1LZI1.
    OMAi IFKEMNN.
    OrthoDBi EOG7GBFWS.
    TreeFami TF315472.

    Miscellaneous databases

    NextBioi 20877083.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Testis.

    Entry informationi

    Entry nameiUD3A1_BOVIN
    AccessioniPrimary (citable) accession number: Q1LZI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3