Reviewed, UniProtKB/Swiss-Prot Q1LZI1 (UD3A1_BOVIN)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 3A1
      Short name=UDPGT 3A1
    EC=2.4.1.17

Gene names

Name:

UGT3A1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 523	501	UDP-glucuronosyltransferase 3A1		PRO_0000299149
Regions
	Topological domain	23 – 483	461	Extracellular Potential
	Transmembrane	484 – 504	21	Potential
	Topological domain	505 – 523	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	52	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1LZI1-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: BBD64418540DD647	FASTA	523	59,682
	10 20 30 40 50 60 MAGQQALLLF GFILPGLLFS EAAKILTVSL VGGSHFLLMH QISQILQDHG HNVTMLLQKG 70 80 90 100 110 120 NLLLPGFKEE EKSYKVFNWF LPEDCNEEFK RSFHSFMEKT FGGRCKFEHF LNIMELLGHH 130 140 150 160 170 180 CSHLLRRKDV MKSLKNENFD LVIVEMFDYC PFLVAEKLGK PFVAILPSAL GTVDFGLPSP 190 200 210 220 230 240 LSYVPVFYSL LTDQMDFWGR VKNFLMFFEF FKKQWKIQSA YDDTIKEHFP DDSRPVLSHL 250 260 270 280 290 300 LTKAELWFVN TDFAFDFARP LLPNTVCIGG LMSKPVKPVP QEFENFITKF GDSGFVLVSL 310 320 330 340 350 360 GSMVSFIRSQ EVLKEMNAAF AHLPQGVIWK YNPSHWPKDI KLAPNVKIVH WLPQNDLLGH 370 380 390 400 410 420 PRIRLFVSHG GMNSIMEAIQ HGVPMVGIPL FGDQHENLLR VKAKKFGVSI QLKQIKAETL 430 440 450 460 470 480 ALKMKQVIED KRYKSAAEAA SIIRRSQPLT PAQRLVGWIN HILQTGGAAH LKPHAFQQPW 490 500 510 520 YEQYLLDVFL FLLVVTLGTM WLCGKLLGLV ARWLCGARKL KKA

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC115988 mRNA. Translation: AAI15989.1.
IPI	IPI00700950.
RefSeq	NP_001069555.1.
UniGene	Bt.17923
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSBTAG00000002701. Bos taurus. [Contig view]
GeneID	537188.
KEGG	bta:537188.
Phylogenomic databases
HOVERGEN	Q1LZI1.
Enzyme and pathway databases
BRENDA	2.4.1.17. 251.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD3A1_BOVIN

Accession

Primary (citable) accession number: Q1LZI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	May 30, 2006
Last modified:	April 14, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)