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Q1LZI1

- UD3A1_BOVIN

UniProt

Q1LZI1 - UD3A1_BOVIN

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Protein
UDP-glucuronosyltransferase 3A1
Gene
UGT3A1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A1 (EC:2.4.1.17)
Short name:
UDPGT 3A1
Gene namesi
Name:UGT3A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 483461Extracellular Reviewed prediction
Add
BLAST
Transmembranei484 – 50421Helical; Reviewed prediction
Add
BLAST
Topological domaini505 – 52319Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 523501UDP-glucuronosyltransferase 3A1
PRO_0000299149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ1LZI1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003497.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00560000076760.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ1LZI1.
OMAiIFKEMNN.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LZI1-1 [UniParc]FASTAAdd to Basket

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MAGQQALLLF GFILPGLLFS EAAKILTVSL VGGSHFLLMH QISQILQDHG    50
HNVTMLLQKG NLLLPGFKEE EKSYKVFNWF LPEDCNEEFK RSFHSFMEKT 100
FGGRCKFEHF LNIMELLGHH CSHLLRRKDV MKSLKNENFD LVIVEMFDYC 150
PFLVAEKLGK PFVAILPSAL GTVDFGLPSP LSYVPVFYSL LTDQMDFWGR 200
VKNFLMFFEF FKKQWKIQSA YDDTIKEHFP DDSRPVLSHL LTKAELWFVN 250
TDFAFDFARP LLPNTVCIGG LMSKPVKPVP QEFENFITKF GDSGFVLVSL 300
GSMVSFIRSQ EVLKEMNAAF AHLPQGVIWK YNPSHWPKDI KLAPNVKIVH 350
WLPQNDLLGH PRIRLFVSHG GMNSIMEAIQ HGVPMVGIPL FGDQHENLLR 400
VKAKKFGVSI QLKQIKAETL ALKMKQVIED KRYKSAAEAA SIIRRSQPLT 450
PAQRLVGWIN HILQTGGAAH LKPHAFQQPW YEQYLLDVFL FLLVVTLGTM 500
WLCGKLLGLV ARWLCGARKL KKA 523
Length:523
Mass (Da):59,682
Last modified:May 30, 2006 - v1
Checksum:iBBD64418540DD647
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC115988 mRNA. Translation: AAI15989.1.
RefSeqiNP_001069555.1. NM_001076087.1.
UniGeneiBt.17923.

Genome annotation databases

EnsembliENSBTAT00000003497; ENSBTAP00000003497; ENSBTAG00000002701.
GeneIDi537188.
KEGGibta:537188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC115988 mRNA. Translation: AAI15989.1 .
RefSeqi NP_001069555.1. NM_001076087.1.
UniGenei Bt.17923.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000003497.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi Q1LZI1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000003497 ; ENSBTAP00000003497 ; ENSBTAG00000002701 .
GeneIDi 537188.
KEGGi bta:537188.

Phylogenomic databases

eggNOGi COG1819.
GeneTreei ENSGT00560000076760.
HOGENOMi HOG000220831.
HOVERGENi HBG106370.
InParanoidi Q1LZI1.
OMAi IFKEMNN.
OrthoDBi EOG7GBFWS.
TreeFami TF315472.

Miscellaneous databases

NextBioi 20877083.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiUD3A1_BOVIN
AccessioniPrimary (citable) accession number: Q1LZI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 30, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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