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Protein

N-acetylglucosamine-6-sulfatase

Gene

GNS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63CalciumBy similarity1
Metal bindingi64CalciumBy similarity1
Metal bindingi99Calcium; via 3-oxoalanineBy similarity1
Metal bindingi334CalciumBy similarity1
Metal bindingi335CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-sulfatase (EC:3.1.6.14)
Alternative name(s):
Glucosamine-6-sulfatase
Short name:
G6S
Gene namesi
Name:GNS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 48Sequence analysisAdd BLAST48
ChainiPRO_000027318849 – 560N-acetylglucosamine-6-sulfataseAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei993-oxoalanine (Cys)By similarity1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1
Glycosylationi395N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1
Glycosylationi430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi488N-linked (GlcNAc...)Sequence analysis1
Modified residuei549PhosphoserineBy similarity1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ1LZH9.
PRIDEiQ1LZH9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023218.

Structurei

3D structure databases

ProteinModelPortaliQ1LZH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3731. Eukaryota.
COG3119. LUCA.
HOGENOMiHOG000169239.
HOVERGENiHBG005840.
InParanoidiQ1LZH9.
KOiK01137.

Family and domain databases

Gene3Di3.40.720.10. 3 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR012251. GlcNAc_6-SO4ase.
IPR015981. GlcNAc_6-SO4ase_euk.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PANTHERiPTHR10342:SF212. PTHR10342:SF212. 1 hit.
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
PIRSFiPIRSF036666. G6S. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LZH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLSLAPDR PRRGGPRHLT SGSPALPPPP PLLLLLLLLG GCLGVSGAAK
60 70 80 90 100
SSRRPNVVLL LADDQDEVLG GMTPLKKTKA LIGEMGMTFS SAYVPSALCC
110 120 130 140 150
PSRASILTGK YPHNLHVVNN TLEGNCSSKS WQKIQEPNTF PAILRSMCGY
160 170 180 190 200
QTFFAGKYLN EYGAPDAGGL GHVPLGWSYW YALEKNSKYY NYTLSINGKA
210 220 230 240 250
RKHGENYSVD YLTDVLANVS LDFLDYKSNS EPFFMMISTP APHSPWTAAP
260 270 280 290 300
QYQNAFQNVF APRNKNFNIH GTNKHWLIRQ AKTPMTNSSI QFLDNAFRKR
310 320 330 340 350
WQTLLSVDDL VEKLVKRLEF NGELNNTYIF YTSDNGYHTG QFSLPIDKRQ
360 370 380 390 400
LYEFDIKVPL LVRGPGIKPN QTSKMLVANI DLGPTILDIA GYSLNKTQMD
410 420 430 440 450
GMSFLPILKG ASNLTWRSDV LVEYQGEGRN VTDPTCPSLS PGVSQCFPDC
460 470 480 490 500
VCEDAYNNTY ACVRTMSERW NLQYCEFDDQ EVFVEVYNLT ADPHQLNNIA
510 520 530 540 550
KSIDPELLGK MNYRLMMLQS CSGPTCRTPG VFDPGYRFDP RLMFSNHGSV
560
RTRRFSKHLL
Length:560
Mass (Da):62,776
Last modified:May 30, 2006 - v1
Checksum:iFF7507C6FD22D3C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115990 mRNA. Translation: AAI15991.1.
RefSeqiNP_001069030.1. NM_001075562.2.
UniGeneiBt.20235.

Genome annotation databases

GeneIDi512444.
KEGGibta:512444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115990 mRNA. Translation: AAI15991.1.
RefSeqiNP_001069030.1. NM_001075562.2.
UniGeneiBt.20235.

3D structure databases

ProteinModelPortaliQ1LZH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023218.

Proteomic databases

PaxDbiQ1LZH9.
PRIDEiQ1LZH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi512444.
KEGGibta:512444.

Organism-specific databases

CTDi2799.

Phylogenomic databases

eggNOGiKOG3731. Eukaryota.
COG3119. LUCA.
HOGENOMiHOG000169239.
HOVERGENiHBG005840.
InParanoidiQ1LZH9.
KOiK01137.

Family and domain databases

Gene3Di3.40.720.10. 3 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR012251. GlcNAc_6-SO4ase.
IPR015981. GlcNAc_6-SO4ase_euk.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PANTHERiPTHR10342:SF212. PTHR10342:SF212. 1 hit.
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
PIRSFiPIRSF036666. G6S. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGNS_BOVIN
AccessioniPrimary (citable) accession number: Q1LZH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 30, 2006
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.