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Protein

G2/mitotic-specific cyclin-B1

Gene

CCNB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-BTA-113507. E2F-enabled inhibition of pre-replication complex formation.
R-BTA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-BTA-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-BTA-176412. Phosphorylation of the APC/C.
R-BTA-176417. Phosphorylation of Emi1.
R-BTA-2299718. Condensation of Prophase Chromosomes.
R-BTA-2500257. Resolution of Sister Chromatid Cohesion.
R-BTA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-BTA-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-BTA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-BTA-380320. Recruitment of NuMA to mitotic centrosomes.
R-BTA-4419969. Depolymerisation of the Nuclear Lamina.
R-BTA-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-BTA-69273. Cyclin A/B1 associated events during G2/M transition.
R-BTA-69478. G2/M DNA replication checkpoint.
R-BTA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
R-BTA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B1
Gene namesi
Name:CCNB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427G2/mitotic-specific cyclin-B1PRO_0000282330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei73 – 731N6-acetyllysineBy similarity
Modified residuei120 – 1201Phosphoserine; by CDK1By similarity
Modified residuei122 – 1221PhosphoserineBy similarity
Modified residuei127 – 1271Phosphoserine; by PLK1By similarity
Modified residuei141 – 1411PhosphoserineBy similarity
Modified residuei315 – 3151PhosphothreonineBy similarity

Post-translational modificationi

Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases (By similarity).By similarity
Phosphorylated by PLK1 at Ser-127 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-141 was also reported to be mediated by PLK1 but Ser-127 seems to be the primary phosphorylation site (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ1LZG6.
PRIDEiQ1LZG6.

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

BgeeiENSBTAG00000014239.

Interactioni

Subunit structurei

Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025670.

Structurei

3D structure databases

ProteinModelPortaliQ1LZG6.
SMRiQ1LZG6. Positions 161-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1719Interaction with CDK2By similarity
Regioni252 – 2554Interaction with CDK2By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 8535Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiQ1LZG6.
KOiK05868.
OMAiHMTVKNK.
OrthoDBiEOG091G0E9B.
TreeFamiTF101001.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1LZG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRITRNTK ISAENKAKIS MAGAKRVPVA AVATSKPGLR PRTALGDIGN
60 70 80 90 100
KVSEQPQAKL PLKKEAKTLA SGKVTAKKVP KPLEKAPVPV PEPQPEPEPE
110 120 130 140 150
PEHVKEDKLS PEPILVDTPS PSPMETSGCA PAEEYLCQAF SDVILAVSDV
160 170 180 190 200
DAEDGADPNL CSEYVKDIYA YLRQLEEEQA VKPKYLMGRE VTGNMRAILI
210 220 230 240 250
DWLVQVQIKF RLLQETMYMT VSIIDRFMQD TYVPKKMLQL VGVTAMFVAS
260 270 280 290 300
KYEEMYPPEI GDFAFVTDNT YTKFQIRQME MKILRALNFS LGRPLPLHFL
310 320 330 340 350
RRASKIGEVD VELHTLAKYL MELTMLDYDM VHFPPSQIAA GAFCLALKVL
360 370 380 390 400
DNGEWTPTLQ HYLSYTEESL LVVMQHLAKN VVMVNRGLTK HMTIKNKYAT
410 420
SKHAKISTLA QLNSALVQDL AKAVAKV
Length:427
Mass (Da):47,658
Last modified:May 30, 2006 - v1
Checksum:iD74D586F0FCD610D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116011 mRNA. Translation: AAI16012.1.
RefSeqiNP_001039337.1. NM_001045872.1.
UniGeneiBt.15980.

Genome annotation databases

EnsembliENSBTAT00000025670; ENSBTAP00000025670; ENSBTAG00000014239.
GeneIDi327679.
KEGGibta:327679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116011 mRNA. Translation: AAI16012.1.
RefSeqiNP_001039337.1. NM_001045872.1.
UniGeneiBt.15980.

3D structure databases

ProteinModelPortaliQ1LZG6.
SMRiQ1LZG6. Positions 161-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025670.

Proteomic databases

PaxDbiQ1LZG6.
PRIDEiQ1LZG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025670; ENSBTAP00000025670; ENSBTAG00000014239.
GeneIDi327679.
KEGGibta:327679.

Organism-specific databases

CTDi891.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiQ1LZG6.
KOiK05868.
OMAiHMTVKNK.
OrthoDBiEOG091G0E9B.
TreeFamiTF101001.

Enzyme and pathway databases

ReactomeiR-BTA-113507. E2F-enabled inhibition of pre-replication complex formation.
R-BTA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-BTA-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-BTA-176412. Phosphorylation of the APC/C.
R-BTA-176417. Phosphorylation of Emi1.
R-BTA-2299718. Condensation of Prophase Chromosomes.
R-BTA-2500257. Resolution of Sister Chromatid Cohesion.
R-BTA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-BTA-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-BTA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-BTA-380320. Recruitment of NuMA to mitotic centrosomes.
R-BTA-4419969. Depolymerisation of the Nuclear Lamina.
R-BTA-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-BTA-69273. Cyclin A/B1 associated events during G2/M transition.
R-BTA-69478. G2/M DNA replication checkpoint.
R-BTA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
R-BTA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Gene expression databases

BgeeiENSBTAG00000014239.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCNB1_BOVIN
AccessioniPrimary (citable) accession number: Q1LZG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.