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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

PTH1R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
Gene namesi
Name:PTH1R
Synonyms:PTHR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 188ExtracellularSequence analysisAdd BLAST160
Transmembranei189 – 209Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini210 – 223CytoplasmicSequence analysisAdd BLAST14
Transmembranei224 – 244Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini245 – 294ExtracellularSequence analysisAdd BLAST50
Transmembranei295 – 315Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini316 – 318CytoplasmicSequence analysis3
Transmembranei319 – 339Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini340 – 360ExtracellularSequence analysisAdd BLAST21
Transmembranei361 – 381Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini382 – 404CytoplasmicSequence analysisAdd BLAST23
Transmembranei405 – 425Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini426 – 439ExtracellularSequence analysisAdd BLAST14
Transmembranei440 – 460Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini461 – 589CytoplasmicSequence analysisAdd BLAST129

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000025099029 – 589Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 117By similarity
Disulfide bondi108 ↔ 148By similarity
Disulfide bondi131 ↔ 170By similarity
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Modified residuei547PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ1LZF7.
PRIDEiQ1LZF7.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022555.

Structurei

3D structure databases

ProteinModelPortaliQ1LZF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi473 – 476Important for interaction with G proteinsBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi268 – 271Poly-Pro4
Compositional biasi272 – 275Poly-Ala4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ1LZF7.
KOiK04585.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LZF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK
60 70 80 90 100
RLKEVLQRPA DIMESDKGWA SASTSGKPKK EKPSGKLHPE SEEDKEVPTG
110 120 130 140 150
SRPRGRPCLP EWDHILCWPL GAPGEVVAMP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGTAL
260 270 280 290 300
DEAERLTEEE LRAIAQAPPP PAAAAGYVGC RVAVTFFLYF LATNYYWILV
310 320 330 340 350
EGLYLHSLIF MAFFSEKKYL WGFTVFGWGL PAIFVAVWVS VRATLANTGC
360 370 380 390 400
WDLSSGNKKW IIQVPILASI VLNFILFINI VRVLATKLRE TNAGRCDTRQ
410 420 430 440 450
QYRKLLKSTL VLMPLFGVHY IVFMATPYTE VSGTLWQVQM HYEMLFNSFQ
460 470 480 490 500
GFFVAIIYCF CNGEVQAEIK KSWSRWTLAL DFKRKARSGS SSYSYGPMVS
510 520 530 540 550
HTSVTNVGPR TGLGLPLSPR LLPAATTNGH PPLPGHTKSG SPALQATPPA
560 570 580
VAAPKEDGFL NGSCSGLDEE ACAPERPPVL LQEEWETVM
Length:589
Mass (Da):65,862
Last modified:May 30, 2006 - v1
Checksum:i65C4E7970ED2CB71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116022 mRNA. Translation: AAI16023.1.
RefSeqiNP_001068800.1. NM_001075332.1.
UniGeneiBt.41304.

Genome annotation databases

GeneIDi507783.
KEGGibta:507783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116022 mRNA. Translation: AAI16023.1.
RefSeqiNP_001068800.1. NM_001075332.1.
UniGeneiBt.41304.

3D structure databases

ProteinModelPortaliQ1LZF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022555.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ1LZF7.
PRIDEiQ1LZF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi507783.
KEGGibta:507783.

Organism-specific databases

CTDi5745.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ1LZF7.
KOiK04585.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTH1R_BOVIN
AccessioniPrimary (citable) accession number: Q1LZF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 30, 2006
Last modified: October 5, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.