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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

PTH1R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
Gene namesi
Name:PTH1R
Synonyms:PTHR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 188160ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini210 – 22314CytoplasmicSequence analysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini245 – 29450ExtracellularSequence analysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini316 – 3183CytoplasmicSequence analysis
Transmembranei319 – 33921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini340 – 36021ExtracellularSequence analysisAdd
BLAST
Transmembranei361 – 38121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini382 – 40423CytoplasmicSequence analysisAdd
BLAST
Transmembranei405 – 42521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini426 – 43914ExtracellularSequence analysisAdd
BLAST
Transmembranei440 – 46021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini461 – 589129CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 589561Parathyroid hormone/parathyroid hormone-related peptide receptorPRO_0000250990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 117By similarity
Disulfide bondi108 ↔ 148By similarity
Disulfide bondi131 ↔ 170By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Modified residuei547 – 5471PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ1LZF7.
PRIDEiQ1LZF7.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022555.

Structurei

3D structure databases

ProteinModelPortaliQ1LZF7.
SMRiQ1LZF7. Positions 24-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi473 – 4764Important for interaction with G proteinsBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi268 – 2714Poly-Pro
Compositional biasi272 – 2754Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ1LZF7.
KOiK04585.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LZF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK
60 70 80 90 100
RLKEVLQRPA DIMESDKGWA SASTSGKPKK EKPSGKLHPE SEEDKEVPTG
110 120 130 140 150
SRPRGRPCLP EWDHILCWPL GAPGEVVAMP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGTAL
260 270 280 290 300
DEAERLTEEE LRAIAQAPPP PAAAAGYVGC RVAVTFFLYF LATNYYWILV
310 320 330 340 350
EGLYLHSLIF MAFFSEKKYL WGFTVFGWGL PAIFVAVWVS VRATLANTGC
360 370 380 390 400
WDLSSGNKKW IIQVPILASI VLNFILFINI VRVLATKLRE TNAGRCDTRQ
410 420 430 440 450
QYRKLLKSTL VLMPLFGVHY IVFMATPYTE VSGTLWQVQM HYEMLFNSFQ
460 470 480 490 500
GFFVAIIYCF CNGEVQAEIK KSWSRWTLAL DFKRKARSGS SSYSYGPMVS
510 520 530 540 550
HTSVTNVGPR TGLGLPLSPR LLPAATTNGH PPLPGHTKSG SPALQATPPA
560 570 580
VAAPKEDGFL NGSCSGLDEE ACAPERPPVL LQEEWETVM
Length:589
Mass (Da):65,862
Last modified:May 30, 2006 - v1
Checksum:i65C4E7970ED2CB71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116022 mRNA. Translation: AAI16023.1.
RefSeqiNP_001068800.1. NM_001075332.1.
UniGeneiBt.41304.

Genome annotation databases

GeneIDi507783.
KEGGibta:507783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116022 mRNA. Translation: AAI16023.1.
RefSeqiNP_001068800.1. NM_001075332.1.
UniGeneiBt.41304.

3D structure databases

ProteinModelPortaliQ1LZF7.
SMRiQ1LZF7. Positions 24-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022555.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ1LZF7.
PRIDEiQ1LZF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi507783.
KEGGibta:507783.

Organism-specific databases

CTDi5745.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ1LZF7.
KOiK04585.

Miscellaneous databases

NextBioi20868220.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiPTH1R_BOVIN
AccessioniPrimary (citable) accession number: Q1LZF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 30, 2006
Last modified: November 11, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.