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Q1LZA3

- ASNS_BOVIN

UniProt

Q1LZA3 - ASNS_BOVIN

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Protein

Asparagine synthetase [glutamine-hydrolyzing]

Gene
ASNS
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activity By similarity
Binding sitei97 – 971Glutamine By similarity
Binding sitei256 – 2561ATP; via carbonyl oxygen By similarity
Binding sitei288 – 2881ATP; via amide nitrogen and carbonyl oxygen By similarity
Sitei365 – 3651Important for beta-aspartyl-AMP intermediate formation By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi363 – 3642ATP By similarity

GO - Molecular functioni

  1. asparagine synthase (glutamine-hydrolyzing) activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. L-asparagine biosynthetic process Source: UniProtKB-UniPathway
  3. negative regulation of apoptotic process Source: Ensembl
  4. positive regulation of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Asparagine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_204438. ATF4 activates genes.
REACT_217400. Amino acid synthesis and interconversion (transamination).
UniPathwayiUPA00134; UER00195.

Protein family/group databases

MEROPSiC44.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine synthetase [glutamine-hydrolyzing] (EC:6.3.5.4)
Alternative name(s):
Glutamine-dependent asparagine synthetase
Gene namesi
Name:ASNS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 561560Asparagine synthetase [glutamine-hydrolyzing]PRO_0000269563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei385 – 3851N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ1LZA3.
PRIDEiQ1LZA3.

Structurei

3D structure databases

ProteinModelPortaliQ1LZA3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 191190Glutamine amidotransferase type-2Add
BLAST
Domaini213 – 536324Asparagine synthetaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 535Glutamine binding By similarity
Regioni75 – 773Glutamine binding By similarity

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0367.
GeneTreeiENSGT00390000001994.
HOGENOMiHOG000027493.
HOVERGENiHBG003103.
InParanoidiQ1LZA3.
KOiK01953.
OMAiDFINTAM.
OrthoDBiEOG75MVVS.
TreeFamiTF300603.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
InterProiIPR006426. Asn_synth_AEB.
IPR001962. Asn_synthase.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00733. Asn_synthase. 1 hit.
PF13537. GATase_7. 1 hit.
[Graphical view]
PIRSFiPIRSF001589. Asn_synthetase_glu-h. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01536. asn_synth_AEB. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LZA3-1 [UniParc]FASTAAdd to Basket

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MCGIWALFGS DDCLSVQCLS AMKIAHRGPD AFRFENVNGY TNCCFGFHRL    50
AVVDQLFGMQ PIRVKKYPYL WLCYNGEIYN HKKLQHHFEF EYQTKVDGEI 100
ILHLYDKGGI EQTVCMLDGV FAFILLDTAN KKVFLGRDTY GVRPLFKAMT 150
EDGFLAVCSE AKGLVNLKHS MTPFLKVEPF LPGHYEVLDL KPNGKVASVE 200
MVKHHHCRDE PLHALYDGVE KLFPGFEIET VKSNLRILFD NAVKKRLMTD 250
RRIGCLLSGG LDSSLVAATL LKQLKEAQVQ YPLQTFAIGM EDSPDLLAAR 300
KVANHIGSEH HEVLFNSEEG IQVLDEVIFS LETYDITTVR ASVGMYLISK 350
YIRKNTDSVV IFSGEGSDEL TQGYIYFHKA PSPEKAEEES ERLLRELYLF 400
DVLRADRTTA AHGLELRVPF LDHRFSSYYL SLPPDMRVPK NGIEKHLLRE 450
TFEDSNLIPK EILWRPKEAF SDGITSVKNS WFRILQDYIE HQVDDAAMAS 500
AAQKFPINTP KTKEGYYYRQ IFENHYPGRA DWLPHYWMPR WTNATDPSAR 550
TLTHYKAAAK A 561
Length:561
Mass (Da):64,220
Last modified:January 23, 2007 - v3
Checksum:i71379296556DB3D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC116123 mRNA. Translation: AAI16124.1.
RefSeqiNP_001069121.1. NM_001075653.1.
XP_005205202.1. XM_005205145.1.
XP_005205203.1. XM_005205146.1.
UniGeneiBt.61275.

Genome annotation databases

EnsembliENSBTAT00000004181; ENSBTAP00000004181; ENSBTAG00000003222.
GeneIDi514209.
KEGGibta:514209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC116123 mRNA. Translation: AAI16124.1 .
RefSeqi NP_001069121.1. NM_001075653.1.
XP_005205202.1. XM_005205145.1.
XP_005205203.1. XM_005205146.1.
UniGenei Bt.61275.

3D structure databases

ProteinModelPortali Q1LZA3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C44.974.

Proteomic databases

PaxDbi Q1LZA3.
PRIDEi Q1LZA3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000004181 ; ENSBTAP00000004181 ; ENSBTAG00000003222 .
GeneIDi 514209.
KEGGi bta:514209.

Organism-specific databases

CTDi 440.

Phylogenomic databases

eggNOGi COG0367.
GeneTreei ENSGT00390000001994.
HOGENOMi HOG000027493.
HOVERGENi HBG003103.
InParanoidi Q1LZA3.
KOi K01953.
OMAi DFINTAM.
OrthoDBi EOG75MVVS.
TreeFami TF300603.

Enzyme and pathway databases

UniPathwayi UPA00134 ; UER00195 .
Reactomei REACT_204438. ATF4 activates genes.
REACT_217400. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

NextBioi 20871226.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
InterProi IPR006426. Asn_synth_AEB.
IPR001962. Asn_synthase.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00733. Asn_synthase. 1 hit.
PF13537. GATase_7. 1 hit.
[Graphical view ]
PIRSFi PIRSF001589. Asn_synthetase_glu-h. 1 hit.
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01536. asn_synth_AEB. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiASNS_BOVIN
AccessioniPrimary (citable) accession number: Q1LZA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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