ID   CAH1_BOVIN              Reviewed;         261 AA.
AC   Q1LZA1;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Carbonic anhydrase 1;
DE            EC=4.2.1.1;
DE   AltName: Full=Carbonic anhydrase I;
DE            Short=CA-I;
DE   AltName: Full=Carbonate dehydratase I;
GN   Name=CA1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reversible hydration of carbon dioxide (By similarity).
CC   -!- CATALYTIC ACTIVITY: H(2)CO(3) = CO(2) + H(2)O.
CC   -!- COFACTOR: Zinc (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
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DR   EMBL; BC116126; AAI16127.1; -; mRNA.
DR   IPI; IPI00687695; -.
DR   RefSeq; NP_001068934.1; -.
DR   UniGene; Bt.64188; -.
DR   SMR; Q1LZA1; 4-261.
DR   Ensembl; ENSBTAG00000032236; Bos taurus.
DR   GeneID; 510801; -.
DR   KEGG; bta:510801; -.
DR   HOVERGEN; Q1LZA1; -.
DR   OMA; Q1LZA1; TKGKRAP.
DR   BRENDA; 4.2.1.1; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:InterPro.
DR   InterPro; IPR001148; Carbonic_anhydrase_a-class_cat.
DR   InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR   InterPro; IPR018442; Carbonic_anhydrase_CA1.
DR   Gene3D; G3DSA:3.10.200.10; Euk_COanhd; 1.
DR   PANTHER; PTHR18952:SF30; Carbonic_anhydrase_CA1; 1.
DR   PANTHER; PTHR18952; Euk_COanhd; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   ProDom; PD000865; Euk_COanhd; 1.
DR   PROSITE; PS00162; ALPHA_CA_1; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Lyase; Metal-binding; Zinc.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    261       Carbonic anhydrase 1.
FT                                /FTId=PRO_0000262536.
FT   METAL        95     95       Zinc; catalytic (By similarity).
FT   METAL        97     97       Zinc; catalytic (By similarity).
FT   METAL       120    120       Zinc; catalytic (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   261 AA;  28822 MW;  65317265D77C3179 CRC64;
     MASPDWGYDG ENGPEHWGKL YPIANGNNQS PIDIKTSETK RDPSLKPLSV SYNPATAKEI
     VNVGHSFHVN FEDSDNRSVL KGGPLSESYR LRQFHFHWGI TDDCGSEHLV DGAKFSAELH
     LVHWNSAKYP SFADAASQAD GLALIGVLVK VGQANPNLQK VLDALKAVKN KNKKAPFTNF
     DPSVLLPPSL DYWAYSGSLT HPPLHESVTW IIFKETISVS SEQLAQFRSL LANAEGDREV
     HIKQNNRPPQ PLNGRTVKAS F
//