Reviewed, UniProtKB/Swiss-Prot Q1LZA1 (CAH1_BOVIN)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 1
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase I
      Short name=CA-I
    Carbonate dehydratase I

Gene names

Name:

CA1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide By similarity.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
PTM	Acetylation
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 261	260	Carbonic anhydrase 1		PRO_0000262536
Sites
	Metal binding	95	1	Zinc; catalytic By similarity
	Metal binding	97	1	Zinc; catalytic By similarity
	Metal binding	120	1	Zinc; catalytic By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1LZA1-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 65317265D77C3179	FASTA	261	28,822
	10 20 30 40 50 60 MASPDWGYDG ENGPEHWGKL YPIANGNNQS PIDIKTSETK RDPSLKPLSV SYNPATAKEI 70 80 90 100 110 120 VNVGHSFHVN FEDSDNRSVL KGGPLSESYR LRQFHFHWGI TDDCGSEHLV DGAKFSAELH 130 140 150 160 170 180 LVHWNSAKYP SFADAASQAD GLALIGVLVK VGQANPNLQK VLDALKAVKN KNKKAPFTNF 190 200 210 220 230 240 DPSVLLPPSL DYWAYSGSLT HPPLHESVTW IIFKETISVS SEQLAQFRSL LANAEGDREV 250 260 HIKQNNRPPQ PLNGRTVKAS F

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC116126 mRNA. Translation: AAI16127.1.
IPI	IPI00687695.
RefSeq	NP_001068934.1.
UniGene	Bt.64188
3D structure databases
SMR	Q1LZA1. Positions 2-261.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000045723; ENSBTAP00000043090; ENSBTAG00000032236; Bos taurus. [Genome view]
GeneID	510801.
KEGG	bta:510801.
Organism-specific databases
CTD	510801.
Phylogenomic databases
eggNOG	maNOG18235.
HOVERGEN	Q1LZA1.
InParanoid	Q1LZA1.
OMA	VDGVKYS.
OrthoDB	EOG90KBJT.
Enzyme and pathway databases
BRENDA	4.2.1.1. 251.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018442. Carbonic_anhydrase_CA1. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH1_BOVIN

Accession

Primary (citable) accession number: Q1LZA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 31 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)