Reviewed, UniProtKB/Swiss-Prot Q1LZA0 (PIGB_BOVIN)

Names and origin

Protein names

Recommended name:
    GPI mannosyltransferase 3
    EC=2.4.1.-
Alternative name(s):
    GPI mannosyltransferase III
      Short name=GPI-MT-III
    Phosphatidylinositol-glycan biosynthesis class B protein
      Short name=PIG-B

Gene names

Name:

PIGB

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly By similarity.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 22 family. PIGB subfamily.

Ontologies

Keywords
Biological process	GPI-anchor biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	GPI anchor biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell intrinsic to endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 541	541	GPI mannosyltransferase 3		PRO_0000246250
Regions
	Transmembrane	53 – 73	21	Potential
	Transmembrane	126 – 146	21	Potential
	Transmembrane	182 – 202	21	Potential
	Transmembrane	214 – 234	21	Potential
	Transmembrane	245 – 265	21	Potential
	Transmembrane	305 – 325	21	Potential
	Transmembrane	330 – 350	21	Potential
	Transmembrane	352 – 372	21	Potential
	Transmembrane	377 – 397	21	Potential
Amino acid modifications
	Modified residue	31	1	Phosphoserine By similarity
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	417	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1LZA0-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: AE94AC8E1A6CB200	FASTA	541	63,591
	10 20 30 40 50 60 MERDDGGGGG LFFRGLQNRS HEKTKLRTRK STLYLSPQKS TGRCGDLGEN IYLVLFIIAL 70 80 90 100 110 120 RICNCFLVQT SFVPDEYWQS LEVAHRMVFN YGYLTWEWTE RLRGYTYPLI FASIYKILHL 130 140 150 160 170 180 LGKDSVHLLI WIPRLAQALL SAIADLRLYS LMKQLENQQV ARWVFFCQLC SWFTWYCCTR 190 200 210 220 230 240 TLTNTMETVL TIIALFYYPL EGSKSMNSVK YSSLVALAFI IRPTAVIPWI PLLFRHFWQE 250 260 270 280 290 300 QRKLDLILHQ FLPVGFVTLS LSLIIDRIFF GQWTLVQYNF LKFNVLQDLG SFYGSHPWHW 310 320 330 340 350 360 YFSQGFPAVL GTHLPFFIHG CFLAPKRYRI FLVTVLWTLL VYSMLSHKEF RFIYPVLPFC 370 380 390 400 410 420 MVFCGYSLNN LKTWKKPALS FLFLSNMLLA LYTGLVHQRG TLDVMTNIQE LSYNNTNVSS 430 440 450 460 470 480 ASVLMMMPCH STPYYSHVHY PLPMRFLQCP PDLTGKTDYL VEADMFYLNP LKWLYMEFQN 490 500 510 520 530 540 DSQLPTHLIM FSVLEEEISP FLISNNYERT AVFFHTHFPE SRTGSHIYVY ERKLKGKLNQ R

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC116127 mRNA. Translation: AAI16128.1.
IPI	IPI00709569.
RefSeq	NP_001071523.1.
UniGene	Bt.20626
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LZA0.
Protein family/group databases
CAZy	GT22. Glycosyltransferase Family 22.
Genome annotation databases
Ensembl	ENSBTAT00000016934; ENSBTAP00000016934; ENSBTAG00000012740; Bos taurus. [Genome view]
GeneID	616044.
KEGG	bta:616044.
Organism-specific databases
CTD	616044.
Phylogenomic databases
HOVERGEN	Q1LZA0.
Family and domain databases
InterPro	IPR005599. Alg9_trans. [Graphical view]
PANTHER	PTHR22760. Alg9_trans. 1 hit.
Pfam	PF03901. Glyco_transf_22. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PIGB_BOVIN

Accession

Primary (citable) accession number: Q1LZA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	May 30, 2006
Last modified:	October 13, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)