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Protein

GPI mannosyltransferase 3

Gene

PIGB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 3 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase III
Short name:
GPI-MT-III
Phosphatidylinositol-glycan biosynthesis class B protein
Short name:
PIG-B
Gene namesi
Name:PIGB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541GPI mannosyltransferase 3PRO_0000246250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ1LZA0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189846.
HOVERGENiHBG082136.
InParanoidiQ1LZA0.
KOiK05286.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1LZA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERDDGGGGG LFFRGLQNRS HEKTKLRTRK STLYLSPQKS TGRCGDLGEN
60 70 80 90 100
IYLVLFIIAL RICNCFLVQT SFVPDEYWQS LEVAHRMVFN YGYLTWEWTE
110 120 130 140 150
RLRGYTYPLI FASIYKILHL LGKDSVHLLI WIPRLAQALL SAIADLRLYS
160 170 180 190 200
LMKQLENQQV ARWVFFCQLC SWFTWYCCTR TLTNTMETVL TIIALFYYPL
210 220 230 240 250
EGSKSMNSVK YSSLVALAFI IRPTAVIPWI PLLFRHFWQE QRKLDLILHQ
260 270 280 290 300
FLPVGFVTLS LSLIIDRIFF GQWTLVQYNF LKFNVLQDLG SFYGSHPWHW
310 320 330 340 350
YFSQGFPAVL GTHLPFFIHG CFLAPKRYRI FLVTVLWTLL VYSMLSHKEF
360 370 380 390 400
RFIYPVLPFC MVFCGYSLNN LKTWKKPALS FLFLSNMLLA LYTGLVHQRG
410 420 430 440 450
TLDVMTNIQE LSYNNTNVSS ASVLMMMPCH STPYYSHVHY PLPMRFLQCP
460 470 480 490 500
PDLTGKTDYL VEADMFYLNP LKWLYMEFQN DSQLPTHLIM FSVLEEEISP
510 520 530 540
FLISNNYERT AVFFHTHFPE SRTGSHIYVY ERKLKGKLNQ R
Length:541
Mass (Da):63,591
Last modified:May 30, 2006 - v1
Checksum:iAE94AC8E1A6CB200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116127 mRNA. Translation: AAI16128.1.
RefSeqiNP_001071523.1. NM_001078055.1.
UniGeneiBt.20626.

Genome annotation databases

GeneIDi616044.
KEGGibta:616044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116127 mRNA. Translation: AAI16128.1.
RefSeqiNP_001071523.1. NM_001078055.1.
UniGeneiBt.20626.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Proteomic databases

PRIDEiQ1LZA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi616044.
KEGGibta:616044.

Organism-specific databases

CTDi9488.

Phylogenomic databases

HOGENOMiHOG000189846.
HOVERGENiHBG082136.
InParanoidiQ1LZA0.
KOiK05286.

Enzyme and pathway databases

UniPathwayiUPA00196.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiPIGB_BOVIN
AccessioniPrimary (citable) accession number: Q1LZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 30, 2006
Last modified: June 8, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.