Reviewed, UniProtKB/Swiss-Prot Q1LZ95 (IDI1_BOVIN)

Names and origin

Protein names

Recommended name:
    Isopentenyl-diphosphate Delta-isomerase 1
    EC=5.3.3.2
Alternative name(s):
    Isopentenyl pyrophosphate isomerase 1
      Short name=IPP isomerase 1
      Short name=IPPI1

Gene names

Name:

IDI1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity.
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Isoprenoid biosynthesis; dimethylallyl-PP biosynthesis; dimethylallyl-PP from isopentenyl-PP: step 1/1.
Subunit structure	Monomer By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the IPP isomerase type 1 family.

Ontologies

Keywords
Biological process	Carotenoid biosynthesis Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Peroxisome
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Isopentenyl-diphosphate Delta-isomerase 1		PRO_0000287279
Sites
	Active site	86	1	Proton acceptor By similarity
	Active site	148	1
	Metal binding	40	1	Magnesium By similarity
	Metal binding	51	1	Magnesium By similarity
	Metal binding	146	1	Magnesium By similarity
	Metal binding	148	1	Magnesium By similarity
	Binding site	36	1	Substrate By similarity
	Binding site	70	1	Substrate By similarity
	Binding site	74	1	Substrate By similarity
	Binding site	87	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1LZ95-1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: DFD065798697F520	FASTA	227	26,467
	10 20 30 40 50 60 MPEVSTDDLD ERQVQLMAEM CILVDENDRR IGAETKKNCH LNENIERGLL HRAFSVFLFN 70 80 90 100 110 120 TENKLLLQQR SDAKITFPGC FTNTCCSHPL SNPSELEEND AIGVRRAAQR RLKAELGIPM 130 140 150 160 170 180 EEVPPEEINY LTRIHYKAQS DSIWGEHEID YILLVKKNVT LNPDPNEIKS YCYVTKEELE 190 200 210 220 ELIGKAAHGE IKITPWFQII ADTFLFKWWD NLNRLNLFVD HEKIHRM

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC116133 mRNA. Translation: AAI16134.1. Different initiation.
IPI	IPI00717782.
RefSeq	NP_001069127.1.
UniGene	Bt.3764
3D structure databases
SMR	Q1LZ95. Positions 69-287.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000004075. Bos taurus. [Contig view]
GeneID	514293.
KEGG	bta:514293.
Phylogenomic databases
HOVERGEN	Q1LZ95.
Enzyme and pathway databases
BRENDA	5.3.3.2. 251.
Family and domain databases
InterPro	IPR011876. IsopentenylPP_isomerase_typ1. IPR000086. NUDIX_hydrolase_core. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
PANTHER	PTHR10885. IPP_isom_1. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PIRSF	PIRSF018427. Isopntndiph_ism. 1 hit.
ProDom	PD004109. IPP_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR02150. IPP_isom_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI1_BOVIN

Accession

Primary (citable) accession number: Q1LZ95

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	June 16, 2009
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)