Q1LZ94 (RBTN2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rhombotin-2

Alternative name(s):
LIM domain only protein 2
Short name=LMO-2

Gene names

Name:	LMO2
Synonyms:	RBTN2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Subunit structure	Interacts via its LIM domains with ELF2 and LDB1. Interacts with BEX2 and KDM5A. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL By similarity.
Subcellular location	Nucleus Potential.
Domain	The second LIM zinc-binding domain interacts with KDM5A By similarity.
Sequence similarities	Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Cellular component	Nucleus
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to thyroid hormone stimulus Inferred from electronic annotation. Source: Compara embryonic hemopoiesis Inferred from electronic annotation. Source: Compara mRNA transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of erythrocyte differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	E-box binding Inferred from electronic annotation. Source: Compara RNA polymerase II regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara chromatin binding Inferred from electronic annotation. Source: Compara cofactor binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Rhombotin-2		PRO_0000269567
Regions
	Domain	30 – 89	60	LIM zinc-binding 1
	Domain	94 – 153	60	LIM zinc-binding 2

Sequences

	Sequence		Length	Mass (Da)
	Q1LZ94 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: B28AE42505579890	FASTA	158	18,376
	10 20 30 40 50 60 MSSAIERKSL DPSEEPVDEV LQMPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC 70 80 90 100 110 120 GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF 130 140 150 KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC116134 mRNA. Translation: AAI16135.1.
IPI	IPI00688250.
RefSeq	NP_001069820.1. NM_001076352.1.
UniGene	Bt.17081.
3D structure databases
ProteinModelPortal	Q1LZ94.
SMR	Q1LZ94. Positions 26-87.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000009126.
Proteomic databases
PRIDE	Q1LZ94.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000009126; ENSBTAP00000009126; ENSBTAG00000006951.
GeneID	614876.
KEGG	bta:614876.
Organism-specific databases
CTD	4005.
Phylogenomic databases
eggNOG	NOG319108.
GeneTree	ENSGT00680000099670.
HOGENOM	HOG000232175.
HOVERGEN	HBG054231.
InParanoid	Q1LZ94.
KO	K15612.
OMA	CEKRIRA.
OrthoDB	EOG4001KG.
Family and domain databases
Gene3D	2.10.110.10. 2 hits.
InterPro	IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00132. LIM. 2 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20899332.

Entry information

Entry name

RBTN2_BOVIN

Accession

Primary (citable) accession number: Q1LZ94

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 30, 2006
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program