Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gem-associated protein 8

Gene

GEMIN8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Gem-associated protein 8
Short name:
Gemin-8
Gene namesi
Name:GEMIN8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

  • Nucleusgem By similarity
  • Cytoplasm By similarity

  • Note: Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Gem-associated protein 8PRO_0000271400Add
BLAST

Proteomic databases

PaxDbiQ1LZ79.
PRIDEiQ1LZ79.

Interactioni

Subunit structurei

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with SMN1 and with the GEMIN6-GEMIN7 heterodimer, mediating their interaction (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013582.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili130 – 15324Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWPF. Eukaryota.
ENOG4111HJ5. LUCA.
GeneTreeiENSGT00390000013608.
HOGENOMiHOG000049212.
HOVERGENiHBG051527.
InParanoidiQ1LZ79.
KOiK13136.
OMAiNEAAYPQ.
OrthoDBiEOG7BW0M1.
TreeFamiTF328591.

Sequencei

Sequence statusi: Complete.

Q1LZ79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKSESTQA SESWSSHPVY ARYWQHYHQA MAWMRSHQSA YQKAVESVVT
60 70 80 90 100
SPWYYPATDL AQSPAAKGGT SPKSRSKSPS ASGDACRRRS RPGKPGPQRR
110 120 130 140 150
STEKPARFAE DNDSESDDCG IVCDLSNMVI TDELRQYFAE TEQHREELRR
160 170 180 190 200
QHQLDAARLK DYVNADHGLY CDKRGRSTLP PTERPGERRQ AEMKRLYGAS
210 220 230
AAKIQAMETA MQLSFDKHCD RKQPKYWPVI PLKF
Length:234
Mass (Da):26,744
Last modified:May 30, 2006 - v1
Checksum:i10EC6382C00E13E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116157 mRNA. Translation: AAI16158.1.
RefSeqiNP_001069199.1. NM_001075731.2.
UniGeneiBt.2768.

Genome annotation databases

EnsembliENSBTAT00000013582; ENSBTAP00000013582; ENSBTAG00000010289.
GeneIDi515968.
KEGGibta:515968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116157 mRNA. Translation: AAI16158.1.
RefSeqiNP_001069199.1. NM_001075731.2.
UniGeneiBt.2768.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013582.

Proteomic databases

PaxDbiQ1LZ79.
PRIDEiQ1LZ79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013582; ENSBTAP00000013582; ENSBTAG00000010289.
GeneIDi515968.
KEGGibta:515968.

Organism-specific databases

CTDi54960.

Phylogenomic databases

eggNOGiENOG410IWPF. Eukaryota.
ENOG4111HJ5. LUCA.
GeneTreeiENSGT00390000013608.
HOGENOMiHOG000049212.
HOVERGENiHBG051527.
InParanoidiQ1LZ79.
KOiK13136.
OMAiNEAAYPQ.
OrthoDBiEOG7BW0M1.
TreeFamiTF328591.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiGEMI8_BOVIN
AccessioniPrimary (citable) accession number: Q1LZ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 30, 2006
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.