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Protein

Cancer-related nucleoside-triphosphatase homolog

Gene

NTPCR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity).By similarity

Catalytic activityi

NTP + H2O = NDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPBy similarity
Nucleotide bindingi109 – 1168ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cancer-related nucleoside-triphosphatase homolog (EC:3.6.1.15)
Short name:
NTPase
Alternative name(s):
Nucleoside triphosphate phosphohydrolase
Gene namesi
Name:NTPCR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 190189Cancer-related nucleoside-triphosphatase homologPRO_0000278092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei165 – 1651N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ1LZ78.
PRIDEiQ1LZ78.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018514.

Structurei

3D structure databases

ProteinModelPortaliQ1LZ78.
SMRiQ1LZ78. Positions 2-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THEP1 NTPase family.Curated

Phylogenomic databases

eggNOGiENOG410IXTM. Eukaryota.
COG1618. LUCA.
HOVERGENiHBG058637.
InParanoidiQ1LZ78.
KOiK06928.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00796. NTPase_1.
InterProiIPR004948. Nuc-triphosphatase_THEP1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03266. NTPase_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LZ78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARHVFLTGP PGVGKTTLIQ KATEVLKSSG MPVDGFYTEE VRQGGRRIGF
60 70 80 90 100
DVVTLSGIRG PLSRIGSEPL PGKRECRVGQ YVVDLTSFEQ LALPVLRNAG
110 120 130 140 150
ASGRPGQSIC VIDEVGKMEL FSQPFIQAVR QVLSIPGTVV LGTIPVPKGK
160 170 180 190
PLALVEEIRT RKDVKVFSVT KENRNHLLPE IVTHMQSSRK
Length:190
Mass (Da):20,682
Last modified:May 30, 2006 - v1
Checksum:i2FB76296808077DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116158 mRNA. Translation: AAI16159.1.
RefSeqiNP_001069284.1. NM_001075816.2.
UniGeneiBt.23506.

Genome annotation databases

GeneIDi521103.
KEGGibta:521103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116158 mRNA. Translation: AAI16159.1.
RefSeqiNP_001069284.1. NM_001075816.2.
UniGeneiBt.23506.

3D structure databases

ProteinModelPortaliQ1LZ78.
SMRiQ1LZ78. Positions 2-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018514.

Proteomic databases

PaxDbiQ1LZ78.
PRIDEiQ1LZ78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi521103.
KEGGibta:521103.

Organism-specific databases

CTDi84284.

Phylogenomic databases

eggNOGiENOG410IXTM. Eukaryota.
COG1618. LUCA.
HOVERGENiHBG058637.
InParanoidiQ1LZ78.
KOiK06928.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00796. NTPase_1.
InterProiIPR004948. Nuc-triphosphatase_THEP1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03266. NTPase_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiNTPCR_BOVIN
AccessioniPrimary (citable) accession number: Q1LZ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 30, 2006
Last modified: June 8, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.