Q1LZ78 (NTPCR_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cancer-related nucleoside-triphosphatase homolog
Short name=NTPase
EC=3.6.1.15

Alternative name(s):
Nucleoside triphosphate phosphohydrolase

Gene names

Name:

NTPCR

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the THEP1 NTPase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: EC nucleotide phosphatase activity Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 190	189	Cancer-related nucleoside-triphosphatase homolog		PRO_0000278092
Regions
	Nucleotide binding	9 – 16	8	ATP By similarity
	Nucleotide binding	109 – 116	8	ATP By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	21	1	N6-acetyllysine By similarity
	Modified residue	165	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1LZ78 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 2FB76296808077DB	FASTA	190	20,682
	10 20 30 40 50 60 MARHVFLTGP PGVGKTTLIQ KATEVLKSSG MPVDGFYTEE VRQGGRRIGF DVVTLSGIRG 70 80 90 100 110 120 PLSRIGSEPL PGKRECRVGQ YVVDLTSFEQ LALPVLRNAG ASGRPGQSIC VIDEVGKMEL 130 140 150 160 170 180 FSQPFIQAVR QVLSIPGTVV LGTIPVPKGK PLALVEEIRT RKDVKVFSVT KENRNHLLPE 190 IVTHMQSSRK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC116158 mRNA. Translation: AAI16159.1.
IPI	IPI00704951.
RefSeq	NP_001069284.1. NM_001075816.1.
UniGene	Bt.23506.
3D structure databases
ProteinModelPortal	Q1LZ78.
SMR	Q1LZ78. Positions 2-190.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LZ78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	521103.
KEGG	bta:521103.
Organism-specific databases
CTD	84284.
Phylogenomic databases
GeneTree	ENSGT00390000018683.
HOVERGEN	HBG058637.
InParanoid	Q1LZ78.
OrthoDB	EOG42FSJM.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR004948. Nuc-triphosphatase_THEP1. [Graphical view]
KO	K06928.
Pfam	PF03266. NTPase_1. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPCR_BOVIN

Accession

Primary (citable) accession number: Q1LZ78

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	May 30, 2006
Last modified:	November 16, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program