Reviewed, UniProtKB/Swiss-Prot Q1LZ78 (CA057_BOVIN)

Names and origin

Protein names	Recommended name:     Nucleoside-triphosphatase C1orf57 homolog       Short name=NTPase     EC=3.6.1.15 Alternative name(s):     Nucleoside triphosphate phosphohydrolase
Organism	Bos taurus (Bovine)
Taxonomic identifier	9913 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the THEP1 NTPase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Acetylation
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: EC transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 190	189	Nucleoside-triphosphatase C1orf57 homolog		PRO_0000278092
Regions
	Nucleotide binding	9 – 16	8	ATP By similarity
	Nucleotide binding	109 – 116	8	ATP By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	21	1	N6-acetyllysine By similarity
	Modified residue	165	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1LZ78-1 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 2FB76296808077DB	FASTA	190	20,682
	10 20 30 40 50 60 MARHVFLTGP PGVGKTTLIQ KATEVLKSSG MPVDGFYTEE VRQGGRRIGF DVVTLSGIRG 70 80 90 100 110 120 PLSRIGSEPL PGKRECRVGQ YVVDLTSFEQ LALPVLRNAG ASGRPGQSIC VIDEVGKMEL 130 140 150 160 170 180 FSQPFIQAVR QVLSIPGTVV LGTIPVPKGK PLALVEEIRT RKDVKVFSVT KENRNHLLPE 190 IVTHMQSSRK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC116158 mRNA. Translation: AAI16159.1.
IPI	IPI00704951.
RefSeq	NP_001069284.1.
UniGene	Bt.23506
3D structure databases
SMR	Q1LZ78. Positions 2-190.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1LZ78.
Genome annotation databases
Ensembl	ENSBTAT00000018514; ENSBTAP00000018514; ENSBTAG00000013935; Bos taurus. [Genome view]
GeneID	521103.
KEGG	bta:521103.
Organism-specific databases
CTD	521103.
Phylogenomic databases
HOVERGEN	Q1LZ78.
InParanoid	Q1LZ78.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR004948. DUF265. [Graphical view]
Pfam	PF03266. DUF265. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CA057_BOVIN

Accession

Primary (citable) accession number: Q1LZ78

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	May 30, 2006
Last modified:	December 15, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)