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Q1LZ71

- LFG2_BOVIN

UniProt

Q1LZ71 - LFG2_BOVIN

Protein

Protein lifeguard 2

Gene

FAIM2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (30 May 2006)
      Previous versions | rss
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    Functioni

    Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cerebellar granular layer development Source: UniProtKB
    3. cerebellar Purkinje cell differentiation Source: UniProtKB
    4. cerebellar Purkinje cell layer development Source: UniProtKB
    5. cerebellum development Source: UniProtKB
    6. regulation of neuron apoptotic process Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lifeguard 2
    Alternative name(s):
    Fas apoptotic inhibitory molecule 2
    Gene namesi
    Name:FAIM2
    Synonyms:LFG2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Membrane raft By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: UniProtKB
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Protein lifeguard 2PRO_0000326145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with FAS/TNFRSF6 and BAX.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000023267.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BI1 family. LFG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0670.
    GeneTreeiENSGT00500000044791.
    HOGENOMiHOG000060393.
    HOVERGENiHBG012084.
    InParanoidiQ1LZ71.
    OMAiSCQGVIF.
    OrthoDBiEOG7VB2G8.
    TreeFamiTF319996.

    Family and domain databases

    InterProiIPR006214. Bax_inhibitor_1-related.
    [Graphical view]
    PANTHERiPTHR23291. PTHR23291. 1 hit.
    PfamiPF01027. Bax1-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1LZ71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQGKLSVAN KAPGTEGQQQ ANGEKKETPA VPSAPPSYEE ATSGEGLKAG    50
    AFPPAPSAVP LHPSWAYVDP NSSSSYESGF PTGDHEFFTT FSWDDQKVRR 100
    VFIRKVYTIL LIQLLVTLGV VALFTFCDPV KDYVQANPGW YWASYAVFFA 150
    TYLTLACCSG PRRHFPWNLI LLTIFTLSMA YLTGMLSSYY NTTSVLLCLS 200
    ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI LAILLPFQYV 250
    PWLHAVYAVL GAGVFTLFLA FDTQLLMGSR RHSLSPEEYI FGALNIYLDI 300
    IYIFTFFLQL FGTNRE 316
    Length:316
    Mass (Da):35,184
    Last modified:May 30, 2006 - v1
    Checksum:i64C0898AF6786E03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC116167 mRNA. Translation: AAI16168.1.
    RefSeqiNP_001068886.1. NM_001075418.2.
    UniGeneiBt.34795.

    Genome annotation databases

    EnsembliENSBTAT00000023267; ENSBTAP00000023267; ENSBTAG00000017504.
    GeneIDi509790.
    KEGGibta:509790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC116167 mRNA. Translation: AAI16168.1 .
    RefSeqi NP_001068886.1. NM_001075418.2.
    UniGenei Bt.34795.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000023267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000023267 ; ENSBTAP00000023267 ; ENSBTAG00000017504 .
    GeneIDi 509790.
    KEGGi bta:509790.

    Organism-specific databases

    CTDi 23017.

    Phylogenomic databases

    eggNOGi COG0670.
    GeneTreei ENSGT00500000044791.
    HOGENOMi HOG000060393.
    HOVERGENi HBG012084.
    InParanoidi Q1LZ71.
    OMAi SCQGVIF.
    OrthoDBi EOG7VB2G8.
    TreeFami TF319996.

    Miscellaneous databases

    NextBioi 20869128.

    Family and domain databases

    InterProi IPR006214. Bax_inhibitor_1-related.
    [Graphical view ]
    PANTHERi PTHR23291. PTHR23291. 1 hit.
    Pfami PF01027. Bax1-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pons.

    Entry informationi

    Entry nameiLFG2_BOVIN
    AccessioniPrimary (citable) accession number: Q1LZ71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3