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Q1LZ71

- LFG2_BOVIN

UniProt

Q1LZ71 - LFG2_BOVIN

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Protein
Protein lifeguard 2
Gene
FAIM2, LFG2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cerebellar Purkinje cell differentiation Source: UniProtKB
  3. cerebellar Purkinje cell layer development Source: UniProtKB
  4. cerebellar granular layer development Source: UniProtKB
  5. cerebellum development Source: UniProtKB
  6. regulation of neuron apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 2
Alternative name(s):
Fas apoptotic inhibitory molecule 2
Gene namesi
Name:FAIM2
Synonyms:LFG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Transmembranei138 – 15821Helical; Reviewed prediction
Add
BLAST
Transmembranei165 – 18521Helical; Reviewed prediction
Add
BLAST
Transmembranei194 – 21421Helical; Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST
Transmembranei290 – 31021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: UniProtKB
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Protein lifeguard 2
PRO_0000326145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with FAS/TNFRSF6 and BAX By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023267.

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ1LZ71.
OMAiSCQGVIF.
OrthoDBiEOG7VB2G8.
TreeFamiTF319996.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1LZ71-1 [UniParc]FASTAAdd to Basket

« Hide

MTQGKLSVAN KAPGTEGQQQ ANGEKKETPA VPSAPPSYEE ATSGEGLKAG    50
AFPPAPSAVP LHPSWAYVDP NSSSSYESGF PTGDHEFFTT FSWDDQKVRR 100
VFIRKVYTIL LIQLLVTLGV VALFTFCDPV KDYVQANPGW YWASYAVFFA 150
TYLTLACCSG PRRHFPWNLI LLTIFTLSMA YLTGMLSSYY NTTSVLLCLS 200
ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI LAILLPFQYV 250
PWLHAVYAVL GAGVFTLFLA FDTQLLMGSR RHSLSPEEYI FGALNIYLDI 300
IYIFTFFLQL FGTNRE 316
Length:316
Mass (Da):35,184
Last modified:May 30, 2006 - v1
Checksum:i64C0898AF6786E03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC116167 mRNA. Translation: AAI16168.1.
RefSeqiNP_001068886.1. NM_001075418.2.
UniGeneiBt.34795.

Genome annotation databases

EnsembliENSBTAT00000023267; ENSBTAP00000023267; ENSBTAG00000017504.
GeneIDi509790.
KEGGibta:509790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC116167 mRNA. Translation: AAI16168.1 .
RefSeqi NP_001068886.1. NM_001075418.2.
UniGenei Bt.34795.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000023267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000023267 ; ENSBTAP00000023267 ; ENSBTAG00000017504 .
GeneIDi 509790.
KEGGi bta:509790.

Organism-specific databases

CTDi 23017.

Phylogenomic databases

eggNOGi COG0670.
GeneTreei ENSGT00500000044791.
HOGENOMi HOG000060393.
HOVERGENi HBG012084.
InParanoidi Q1LZ71.
OMAi SCQGVIF.
OrthoDBi EOG7VB2G8.
TreeFami TF319996.

Miscellaneous databases

NextBioi 20869128.

Family and domain databases

InterProi IPR006214. Bax_inhibitor_1-related.
[Graphical view ]
PANTHERi PTHR23291. PTHR23291. 1 hit.
Pfami PF01027. Bax1-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiLFG2_BOVIN
AccessioniPrimary (citable) accession number: Q1LZ71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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