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Protein

Protein lifeguard 2

Gene

FAIM2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 2
Alternative name(s):
Fas apoptotic inhibitory molecule 2
Gene namesi
Name:FAIM2
Synonyms:LFG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261451 – 316Protein lifeguard 2Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ1LZ71.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017504.

Interactioni

Subunit structurei

Interacts with FAS/TNFRSF6 and BAX.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023267.

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322. Eukaryota.
COG0670. LUCA.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ1LZ71.
OMAiQANPAWY.
OrthoDBiEOG091G0JRK.
TreeFamiTF319996.

Family and domain databases

InterProiView protein in InterPro
IPR006214. Bax_inhibitor_1-related.
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiView protein in Pfam
PF01027. Bax1-I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LZ71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGKLSVAN KAPGTEGQQQ ANGEKKETPA VPSAPPSYEE ATSGEGLKAG
60 70 80 90 100
AFPPAPSAVP LHPSWAYVDP NSSSSYESGF PTGDHEFFTT FSWDDQKVRR
110 120 130 140 150
VFIRKVYTIL LIQLLVTLGV VALFTFCDPV KDYVQANPGW YWASYAVFFA
160 170 180 190 200
TYLTLACCSG PRRHFPWNLI LLTIFTLSMA YLTGMLSSYY NTTSVLLCLS
210 220 230 240 250
ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI LAILLPFQYV
260 270 280 290 300
PWLHAVYAVL GAGVFTLFLA FDTQLLMGSR RHSLSPEEYI FGALNIYLDI
310
IYIFTFFLQL FGTNRE
Length:316
Mass (Da):35,184
Last modified:May 30, 2006 - v1
Checksum:i64C0898AF6786E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116167 mRNA. Translation: AAI16168.1.
RefSeqiNP_001068886.1. NM_001075418.2.
UniGeneiBt.34795.

Genome annotation databases

EnsembliENSBTAT00000023267; ENSBTAP00000023267; ENSBTAG00000017504.
GeneIDi509790.
KEGGibta:509790.

Similar proteinsi

Entry informationi

Entry nameiLFG2_BOVIN
AccessioniPrimary (citable) accession number: Q1LZ71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 30, 2006
Last modified: August 30, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families