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Q1LZ71 (LFG2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein lifeguard 2
Alternative name(s):
Fas apoptotic inhibitory molecule 2
Gene names
Name:FAIM2
Synonyms:LFG2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development By similarity.

Subunit structure

Interacts with FAS/TNFRSF6 and BAX By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Membrane raft By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity.

Sequence similarities

Belongs to the BI1 family. LFG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Protein lifeguard 2
PRO_0000326145

Regions

Transmembrane106 – 12621Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane290 – 31021Helical; Potential

Amino acid modifications

Glycosylation1911N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q1LZ71 [UniParc].

Last modified May 30, 2006. Version 1.
Checksum: 64C0898AF6786E03

FASTA31635,184
        10         20         30         40         50         60 
MTQGKLSVAN KAPGTEGQQQ ANGEKKETPA VPSAPPSYEE ATSGEGLKAG AFPPAPSAVP 

        70         80         90        100        110        120 
LHPSWAYVDP NSSSSYESGF PTGDHEFFTT FSWDDQKVRR VFIRKVYTIL LIQLLVTLGV 

       130        140        150        160        170        180 
VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTIFTLSMA 

       190        200        210        220        230        240 
YLTGMLSSYY NTTSVLLCLS ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI 

       250        260        270        280        290        300 
LAILLPFQYV PWLHAVYAVL GAGVFTLFLA FDTQLLMGSR RHSLSPEEYI FGALNIYLDI 

       310 
IYIFTFFLQL FGTNRE 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC116167 mRNA. Translation: AAI16168.1.
RefSeqNP_001068886.1. NM_001075418.2.
UniGeneBt.34795.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000023267.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000023267; ENSBTAP00000023267; ENSBTAG00000017504.
GeneID509790.
KEGGbta:509790.

Organism-specific databases

CTD23017.

Phylogenomic databases

eggNOGCOG0670.
GeneTreeENSGT00500000044791.
HOGENOMHOG000060393.
HOVERGENHBG012084.
InParanoidQ1LZ71.
OMASCQGVIF.
OrthoDBEOG7VB2G8.
TreeFamTF319996.

Family and domain databases

InterProIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERPTHR23291. PTHR23291. 1 hit.
PfamPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20869128.

Entry information

Entry nameLFG2_BOVIN
AccessionPrimary (citable) accession number: Q1LZ71
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 30, 2006
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families