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Q1LY77

- SE1BA_DANRE

UniProt

Q1LY77 - SE1BA_DANRE

Protein

Histone-lysine N-methyltransferase SETD1B-A

Gene

setd1ba

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. nucleotide binding Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SETD1B-A (EC:2.1.1.43)
    Alternative name(s):
    SET domain-containing protein 1B-A
    Gene namesi
    Name:setd1ba
    Synonyms:setd1b
    ORF Names:si:dkey-237o15.4
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-050309-289. setd1ba.

    Subcellular locationi

    Nucleus speckle By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18441844Histone-lysine N-methyltransferase SETD1B-APRO_0000316996Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1138 – 11381Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ1LY77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini128 – 21689RRMPROSITE-ProRule annotationAdd
    BLAST
    Domaini1705 – 1822118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1828 – 184417Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi375 – 786412Pro-richAdd
    BLAST
    Compositional biasi952 – 1116165Glu-richAdd
    BLAST
    Compositional biasi1000 – 108081Ser-richAdd
    BLAST
    Compositional biasi1172 – 1435264Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000168216.
    HOVERGENiHBG055596.
    InParanoidiQ1LY77.
    KOiK11422.
    PhylomeDBiQ1LY77.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1LY77-1 [UniParc]FASTAAdd to Basket

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    MCWKVEIVVY CKRQKPQTRG TQYVPGERNK LNEDHGRRQS SSLANGMDNS     50
    HPICSSGEKR SHHWRSYKLI IDPALKKGSH KVYRYDGHQF STPSFGMSPV 100
    DIVRDPRIGR LWTKYKETDL PVPKFKIDEC YVGRVPPKEV TFAKLNDNVR 150
    EGFLTDMCKK FGDIEEVEIL YNPKNKKHLG IAKVVFETVK AAKDAVQNLH 200
    NTSVMGNIIH VELDPKGENR QRYFQRLING SYTPLTLPVG GEEACDVSPR 250
    SLAEALMACE PSRRLFEGGS SVVAGTTPSG TNTPMSLDTA YSSLRQDTPQ 300
    SQGTPHTPRP SGTPFSQDSS YSSRQGTPAF QANRAESSGG YKSRRHETKF 350
    QDAYNRRPER RYVHGPTQRG NTEQPPSFKQ HQPPEPPSPA FTHTPPPPTS 400
    ANFKTAYSQY QPPIPQEYTV ASYHQPVQRE LDYRRPPQAP PPPSTDFLPV 450
    RDRPTTPPIP EPPPAPETQP TTPPSSTPEP CPSPTQESER NSLDSRIEML 500
    LKPFLNERGD SDAEVRMDGS PISSSSSQLS PIPPQRPSRP SSTGLEDISP 550
    TPLPDSEDDE PIRGTASLLA NSRGMSPTNM HSKSCVGEPR TAIDKMDTGH 600
    QSSGEDMEIS DDEMPGTPIA SGDCDKNIVV NSALSLIQTI PMPPPGFPPL 650
    PHAAGFPLPP HHLPHHSTVS HLPSHHPMLH PLHSYGMMHF LPVDLLSSLP 700
    QLLQMPFQMQ TQMLSRMAQS QHPYAYPYPA PSANPAAMPF GGPYPPLSVV 750
    SAPADTLHGQ PWPLPSMPQF NPAVPPPGYE PQKEDPHKAT IDGVLMAIVK 800
    ELKAIMKKDL NRKMVEVVAF RKFDEWWDKQ ELSAKATLTP VKTGEGKDEE 850
    KERAKPKETM SSHLPWNKGE GLGFEGMGLG IGLRGIRLPS FKVKRKQPPE 900
    PTSTSDNKRV RPSTPVDDEL EDEESERMGR TDGSRVDPAG SSSKRRPARP 950
    LELDSEGEEE EETSGKEESS LSDHEEEPVD DASERLSSGK DLEEEDEKKS 1000
    ESHSSESESS DSSDDEASSS SSSKSGSDSS GSESSSDYES SSEEEEEEEE 1050
    EEERIVGMDD EEDVDARTST SSSTTSTSSS DEEEVVEVKA PSTPTGPPPE 1100
    EEPNELGRLE AVDEAEIDHK PSMVSLIKTK VEEVRPPSPK GLPADELDVD 1150
    LEVKIPVPKT EASLEEVGNL RPPTPTGSFA DSDQDTRPKI PTEDFPRTPG 1200
    HEGPVPLESE TTVPRSLPTP SMHLPLPPSH VPDPQSLLPP PETLPDMPVR 1250
    GRLPTEEDIP RTPGRDLMDR ARGLGKLQST DTVPVTPGSD TPLTGNSLSS 1300
    PHILGSPFSY PAQSPVLSAG IPRTPGRDLT FAPAFPDSAG LSAGLPIHRK 1350
    ASSEILEEKP LFKEPLLSAS PQASLPNNAA SSPFPGPPLP TASLPEPALP 1400
    PQGSPPASIE NSFPASPKEL PVPMIDVPVP LDDTPSKKKL VRSKNKKGIQ 1450
    DSEEPQVTLI EASSLPELPV NNQYPDLPSE SIKEEDGEPA FSEKEESQVP 1500
    TIIPKVEETS FYVEEPIQKT RRQRRGWQEL LLSMHSPVAS PRRPSFMPRS 1550
    DFEEMTILYD IWNDGIDEED IRYLKITYDK MLQQDNAHDW LNDTLWVHHP 1600
    PTNMGSATGV KKKRKEDGIR DHVTGCARSE GYYKIDKKDK MKYLNSSRLQ 1650
    SEEPDVDTQG KSIPAQPQVS TRAGSERRSE QRRLLSSFSC DSDLLKFNQL 1700
    KFRKKKIRFC RSHIHDWGLF AMEPIAADEM VIEYVGQNIR QVIADMREKR 1750
    YEDEGIGSSY MFRVDHDTII DATKCGNFAR FINHSCNPNC YAKVITVESQ 1800
    KKIVIYSRQP INVNEEITYD YKFPIEDEKI PCLCGAENCR GTLN 1844
    Length:1,844
    Mass (Da):204,141
    Last modified:February 20, 2007 - v2
    Checksum:i020BC92CCB797E27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX088560 Genomic DNA. Translation: CAK10781.2.
    DQ851809 mRNA. Translation: ABI34481.1.
    RefSeqiNP_001038599.2. NM_001045134.2.
    UniGeneiDr.80156.

    Genome annotation databases

    GeneIDi567970.
    KEGGidre:567970.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX088560 Genomic DNA. Translation: CAK10781.2 .
    DQ851809 mRNA. Translation: ABI34481.1 .
    RefSeqi NP_001038599.2. NM_001045134.2.
    UniGenei Dr.80156.

    3D structure databases

    ProteinModelPortali Q1LY77.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 567970.
    KEGGi dre:567970.

    Organism-specific databases

    CTDi 567970.
    ZFINi ZDB-GENE-050309-289. setd1ba.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000168216.
    HOVERGENi HBG055596.
    InParanoidi Q1LY77.
    KOi K11422.
    PhylomeDBi Q1LY77.

    Miscellaneous databases

    NextBioi 20888944.
    PROi Q1LY77.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. "Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes."
      Sun X.-J., Xu P.-F., Zhou T., Hu M., Fu C.-T., Zhang Y., Jin Y., Chen Y., Chen S.-J., Huang Q.-H., Liu T.X., Chen Z.
      PLoS ONE 3:E1499-E1499(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1585-1740.
    3. "Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
      Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
      J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1138, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiSE1BA_DANRE
    AccessioniPrimary (citable) accession number: Q1LY77
    Secondary accession number(s): A5XCC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3