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Q1LY77 (SE1BA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SETD1B-A

EC=2.1.1.43
Alternative name(s):
SET domain-containing protein 1B-A
Gene names
Name:setd1ba
Synonyms:setd1b
ORF Names:si:dkey-237o15.4
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length1844 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus speckle By similarity. Chromosome By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Contains 1 post-SET domain.

Contains 1 RRM (RNA recognition motif) domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18441844Histone-lysine N-methyltransferase SETD1B-A
PRO_0000316996

Regions

Domain128 – 21689RRM
Domain1705 – 1822118SET
Domain1828 – 184417Post-SET
Compositional bias375 – 786412Pro-rich
Compositional bias952 – 1116165Glu-rich
Compositional bias1000 – 108081Ser-rich
Compositional bias1172 – 1435264Pro-rich

Amino acid modifications

Modified residue11381Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q1LY77 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 020BC92CCB797E27

FASTA1,844204,141
        10         20         30         40         50         60 
MCWKVEIVVY CKRQKPQTRG TQYVPGERNK LNEDHGRRQS SSLANGMDNS HPICSSGEKR 

        70         80         90        100        110        120 
SHHWRSYKLI IDPALKKGSH KVYRYDGHQF STPSFGMSPV DIVRDPRIGR LWTKYKETDL 

       130        140        150        160        170        180 
PVPKFKIDEC YVGRVPPKEV TFAKLNDNVR EGFLTDMCKK FGDIEEVEIL YNPKNKKHLG 

       190        200        210        220        230        240 
IAKVVFETVK AAKDAVQNLH NTSVMGNIIH VELDPKGENR QRYFQRLING SYTPLTLPVG 

       250        260        270        280        290        300 
GEEACDVSPR SLAEALMACE PSRRLFEGGS SVVAGTTPSG TNTPMSLDTA YSSLRQDTPQ 

       310        320        330        340        350        360 
SQGTPHTPRP SGTPFSQDSS YSSRQGTPAF QANRAESSGG YKSRRHETKF QDAYNRRPER 

       370        380        390        400        410        420 
RYVHGPTQRG NTEQPPSFKQ HQPPEPPSPA FTHTPPPPTS ANFKTAYSQY QPPIPQEYTV 

       430        440        450        460        470        480 
ASYHQPVQRE LDYRRPPQAP PPPSTDFLPV RDRPTTPPIP EPPPAPETQP TTPPSSTPEP 

       490        500        510        520        530        540 
CPSPTQESER NSLDSRIEML LKPFLNERGD SDAEVRMDGS PISSSSSQLS PIPPQRPSRP 

       550        560        570        580        590        600 
SSTGLEDISP TPLPDSEDDE PIRGTASLLA NSRGMSPTNM HSKSCVGEPR TAIDKMDTGH 

       610        620        630        640        650        660 
QSSGEDMEIS DDEMPGTPIA SGDCDKNIVV NSALSLIQTI PMPPPGFPPL PHAAGFPLPP 

       670        680        690        700        710        720 
HHLPHHSTVS HLPSHHPMLH PLHSYGMMHF LPVDLLSSLP QLLQMPFQMQ TQMLSRMAQS 

       730        740        750        760        770        780 
QHPYAYPYPA PSANPAAMPF GGPYPPLSVV SAPADTLHGQ PWPLPSMPQF NPAVPPPGYE 

       790        800        810        820        830        840 
PQKEDPHKAT IDGVLMAIVK ELKAIMKKDL NRKMVEVVAF RKFDEWWDKQ ELSAKATLTP 

       850        860        870        880        890        900 
VKTGEGKDEE KERAKPKETM SSHLPWNKGE GLGFEGMGLG IGLRGIRLPS FKVKRKQPPE 

       910        920        930        940        950        960 
PTSTSDNKRV RPSTPVDDEL EDEESERMGR TDGSRVDPAG SSSKRRPARP LELDSEGEEE 

       970        980        990       1000       1010       1020 
EETSGKEESS LSDHEEEPVD DASERLSSGK DLEEEDEKKS ESHSSESESS DSSDDEASSS 

      1030       1040       1050       1060       1070       1080 
SSSKSGSDSS GSESSSDYES SSEEEEEEEE EEERIVGMDD EEDVDARTST SSSTTSTSSS 

      1090       1100       1110       1120       1130       1140 
DEEEVVEVKA PSTPTGPPPE EEPNELGRLE AVDEAEIDHK PSMVSLIKTK VEEVRPPSPK 

      1150       1160       1170       1180       1190       1200 
GLPADELDVD LEVKIPVPKT EASLEEVGNL RPPTPTGSFA DSDQDTRPKI PTEDFPRTPG 

      1210       1220       1230       1240       1250       1260 
HEGPVPLESE TTVPRSLPTP SMHLPLPPSH VPDPQSLLPP PETLPDMPVR GRLPTEEDIP 

      1270       1280       1290       1300       1310       1320 
RTPGRDLMDR ARGLGKLQST DTVPVTPGSD TPLTGNSLSS PHILGSPFSY PAQSPVLSAG 

      1330       1340       1350       1360       1370       1380 
IPRTPGRDLT FAPAFPDSAG LSAGLPIHRK ASSEILEEKP LFKEPLLSAS PQASLPNNAA 

      1390       1400       1410       1420       1430       1440 
SSPFPGPPLP TASLPEPALP PQGSPPASIE NSFPASPKEL PVPMIDVPVP LDDTPSKKKL 

      1450       1460       1470       1480       1490       1500 
VRSKNKKGIQ DSEEPQVTLI EASSLPELPV NNQYPDLPSE SIKEEDGEPA FSEKEESQVP 

      1510       1520       1530       1540       1550       1560 
TIIPKVEETS FYVEEPIQKT RRQRRGWQEL LLSMHSPVAS PRRPSFMPRS DFEEMTILYD 

      1570       1580       1590       1600       1610       1620 
IWNDGIDEED IRYLKITYDK MLQQDNAHDW LNDTLWVHHP PTNMGSATGV KKKRKEDGIR 

      1630       1640       1650       1660       1670       1680 
DHVTGCARSE GYYKIDKKDK MKYLNSSRLQ SEEPDVDTQG KSIPAQPQVS TRAGSERRSE 

      1690       1700       1710       1720       1730       1740 
QRRLLSSFSC DSDLLKFNQL KFRKKKIRFC RSHIHDWGLF AMEPIAADEM VIEYVGQNIR 

      1750       1760       1770       1780       1790       1800 
QVIADMREKR YEDEGIGSSY MFRVDHDTII DATKCGNFAR FINHSCNPNC YAKVITVESQ 

      1810       1820       1830       1840 
KKIVIYSRQP INVNEEITYD YKFPIEDEKI PCLCGAENCR GTLN 

« Hide

References

« Hide 'large scale' references
[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]"Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes."
Sun X.-J., Xu P.-F., Zhou T., Hu M., Fu C.-T., Zhang Y., Jin Y., Chen Y., Chen S.-J., Huang Q.-H., Liu T.X., Chen Z.
PLoS ONE 3:E1499-E1499(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1585-1740.
[3]"Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1138, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX088560 Genomic DNA. Translation: CAK10781.2.
DQ851809 mRNA. Translation: ABI34481.1.
RefSeqNP_001038599.2. NM_001045134.2.
UniGeneDr.80156.

3D structure databases

ProteinModelPortalQ1LY77.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID567970.
KEGGdre:567970.

Organism-specific databases

CTD567970.
ZFINZDB-GENE-050309-289. setd1ba.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000168216.
HOVERGENHBG055596.
InParanoidQ1LY77.
KOK11422.
PhylomeDBQ1LY77.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view]
PfamPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20888944.
PROQ1LY77.

Entry information

Entry nameSE1BA_DANRE
AccessionPrimary (citable) accession number: Q1LY77
Secondary accession number(s): A5XCC0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families