Reviewed,
UniProtKB/Swiss-Prot Q1LY77 (SE1BA_DANRE)
Last modified
June 16, 2009.
Version 27.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Histone-lysine N-methyltransferase SETD1B-A EC=2.1.1.43 Alternative name(s): SET domain-containing protein 1B-A | ||||||
| Gene names |
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| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) | ||||||
| Taxonomic identifier | 7955 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 1844 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation By similarity. |
| Catalytic activity | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. |
| Subcellular location | Nucleus speckle By similarity. |
| Sequence similarities | Contains 1 post-SET domain. Contains 1 RRM (RNA recognition motif) domain. Contains 1 SET domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | RNA-binding S-adenosyl-L-methionine |
| Molecular function | Activator Chromatin regulator Methyltransferase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW histone-lysine N-methyltransferase activityInferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1844 | 1844 | Histone-lysine N-methyltransferase SETD1B-A | PRO_0000316996 | |||||
Regions | |||||||||
| Domain | 128 – 216 | 89 | RRM | ||||||
| Domain | 1704 – 1826 | 123 | SET | ||||||
| Domain | 1828 – 1844 | 17 | Post-SET | ||||||
| Compositional bias | 375 – 786 | 412 | Pro-rich | ||||||
| Compositional bias | 952 – 1116 | 165 | Glu-rich | ||||||
| Compositional bias | 1000 – 1080 | 81 | Ser-rich | ||||||
| Compositional bias | 1172 – 1435 | 264 | Pro-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1138 | 1 | Phosphoserine Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | The Danio rerio sequencing project at the Sanger Institute Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen. |
| [2] | "Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes." Sun X.-J., Xu P.-F., Zhou T., Hu M., Fu C.-T., Zhang Y., Jin Y., Chen Y., Chen S.-J., Huang Q.-H., Liu T.X., Chen Z. PLoS ONE 3:E1499-E1499(2008) [PubMed: 18231586] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1585-1740. |
| [3] | "Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo." Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R. J. Proteome Res. 7:1555-1564(2008) [PubMed: 18307296] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1138, MASS SPECTROMETRY. Tissue: Embryo. |
Cross-references
Sequence databases | |
|---|---|
| BX088560 Genomic DNA. Translation: CAK10781.2. DQ851809 mRNA. Translation: ABI34481.1. | |
| IPI | IPI00608851. |
| RefSeq | NP_001038599.2. |
| UniGene | Dr.149131 Dr.80156 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSDARG00000060847. Danio rerio. [Contig view] ENSDARG00000078930. Danio rerio. [Contig view] |
| GeneID | 567970. |
| KEGG | dre:567970. |
Organism-specific databases | |
| ZFIN | ZDB-GENE-050309-289. setd1ba. |
Phylogenomic databases | |
| HOVERGEN | Q1LY77. |
Enzyme and pathway databases | |
| BRENDA | 2.1.1.43. 96826. |
Gene expression databases | |
| Bgee | Q1LY77. |
Family and domain databases | |
| InterPro | IPR012677. a_b_plait_nuc_bd. IPR015722. MLL. IPR003616. Post-SET_Zn_bd. IPR000504. RRM_RNP1. IPR001214. SET. [Graphical view] |
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit. |
| PANTHER | PTHR22884:SF10. MLL. 1 hit. |
| Pfam | PF00076. RRM_1. 1 hit. PF00856. SET. 1 hit. [Graphical view] |
| SMART | SM00508. PostSET. 1 hit. SM00360. RRM. 1 hit. SM00317. SET. 1 hit. [Graphical view] |
| PROSITE | PS50868. POST_SET. 1 hit. PS50102. RRM. 1 hit. PS50280. SET. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SE1BA_DANRE | ||||||||
| Accession | Primary (citable) accession number: Q1LY77 Secondary accession number(s): A5XCC0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Zebrafish annotation project | ||||||||
