Q1LY77 (SE1BA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase SETD1B-A
EC=2.1.1.43

Alternative name(s):
SET domain-containing protein 1B-A

Gene names

Name:	setd1ba
Synonyms:	setd1b
ORF Names:	si:dkey-237o15.4

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	1844 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus speckle By similarity. Chromosome By similarity.
Sequence similarities	Contains 1 post-SET domain. Contains 1 RRM (RNA recognition motif) domain. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Activator Chromatin regulator Methyltransferase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1844	1844	Histone-lysine N-methyltransferase SETD1B-A		PRO_0000316996
Regions
	Domain	128 – 216	89	RRM
	Domain	1704 – 1826	123	SET
	Domain	1828 – 1844	17	Post-SET
	Compositional bias	375 – 786	412	Pro-rich
	Compositional bias	952 – 1116	165	Glu-rich
	Compositional bias	1000 – 1080	81	Ser-rich
	Compositional bias	1172 – 1435	264	Pro-rich
Amino acid modifications
	Modified residue	1138	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q1LY77 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 020BC92CCB797E27	FASTA	1,844	204,141
	10 20 30 40 50 60 MCWKVEIVVY CKRQKPQTRG TQYVPGERNK LNEDHGRRQS SSLANGMDNS HPICSSGEKR 70 80 90 100 110 120 SHHWRSYKLI IDPALKKGSH KVYRYDGHQF STPSFGMSPV DIVRDPRIGR LWTKYKETDL 130 140 150 160 170 180 PVPKFKIDEC YVGRVPPKEV TFAKLNDNVR EGFLTDMCKK FGDIEEVEIL YNPKNKKHLG 190 200 210 220 230 240 IAKVVFETVK AAKDAVQNLH NTSVMGNIIH VELDPKGENR QRYFQRLING SYTPLTLPVG 250 260 270 280 290 300 GEEACDVSPR SLAEALMACE PSRRLFEGGS SVVAGTTPSG TNTPMSLDTA YSSLRQDTPQ 310 320 330 340 350 360 SQGTPHTPRP SGTPFSQDSS YSSRQGTPAF QANRAESSGG YKSRRHETKF QDAYNRRPER 370 380 390 400 410 420 RYVHGPTQRG NTEQPPSFKQ HQPPEPPSPA FTHTPPPPTS ANFKTAYSQY QPPIPQEYTV 430 440 450 460 470 480 ASYHQPVQRE LDYRRPPQAP PPPSTDFLPV RDRPTTPPIP EPPPAPETQP TTPPSSTPEP 490 500 510 520 530 540 CPSPTQESER NSLDSRIEML LKPFLNERGD SDAEVRMDGS PISSSSSQLS PIPPQRPSRP 550 560 570 580 590 600 SSTGLEDISP TPLPDSEDDE PIRGTASLLA NSRGMSPTNM HSKSCVGEPR TAIDKMDTGH 610 620 630 640 650 660 QSSGEDMEIS DDEMPGTPIA SGDCDKNIVV NSALSLIQTI PMPPPGFPPL PHAAGFPLPP 670 680 690 700 710 720 HHLPHHSTVS HLPSHHPMLH PLHSYGMMHF LPVDLLSSLP QLLQMPFQMQ TQMLSRMAQS 730 740 750 760 770 780 QHPYAYPYPA PSANPAAMPF GGPYPPLSVV SAPADTLHGQ PWPLPSMPQF NPAVPPPGYE 790 800 810 820 830 840 PQKEDPHKAT IDGVLMAIVK ELKAIMKKDL NRKMVEVVAF RKFDEWWDKQ ELSAKATLTP 850 860 870 880 890 900 VKTGEGKDEE KERAKPKETM SSHLPWNKGE GLGFEGMGLG IGLRGIRLPS FKVKRKQPPE 910 920 930 940 950 960 PTSTSDNKRV RPSTPVDDEL EDEESERMGR TDGSRVDPAG SSSKRRPARP LELDSEGEEE 970 980 990 1000 1010 1020 EETSGKEESS LSDHEEEPVD DASERLSSGK DLEEEDEKKS ESHSSESESS DSSDDEASSS 1030 1040 1050 1060 1070 1080 SSSKSGSDSS GSESSSDYES SSEEEEEEEE EEERIVGMDD EEDVDARTST SSSTTSTSSS 1090 1100 1110 1120 1130 1140 DEEEVVEVKA PSTPTGPPPE EEPNELGRLE AVDEAEIDHK PSMVSLIKTK VEEVRPPSPK 1150 1160 1170 1180 1190 1200 GLPADELDVD LEVKIPVPKT EASLEEVGNL RPPTPTGSFA DSDQDTRPKI PTEDFPRTPG 1210 1220 1230 1240 1250 1260 HEGPVPLESE TTVPRSLPTP SMHLPLPPSH VPDPQSLLPP PETLPDMPVR GRLPTEEDIP 1270 1280 1290 1300 1310 1320 RTPGRDLMDR ARGLGKLQST DTVPVTPGSD TPLTGNSLSS PHILGSPFSY PAQSPVLSAG 1330 1340 1350 1360 1370 1380 IPRTPGRDLT FAPAFPDSAG LSAGLPIHRK ASSEILEEKP LFKEPLLSAS PQASLPNNAA 1390 1400 1410 1420 1430 1440 SSPFPGPPLP TASLPEPALP PQGSPPASIE NSFPASPKEL PVPMIDVPVP LDDTPSKKKL 1450 1460 1470 1480 1490 1500 VRSKNKKGIQ DSEEPQVTLI EASSLPELPV NNQYPDLPSE SIKEEDGEPA FSEKEESQVP 1510 1520 1530 1540 1550 1560 TIIPKVEETS FYVEEPIQKT RRQRRGWQEL LLSMHSPVAS PRRPSFMPRS DFEEMTILYD 1570 1580 1590 1600 1610 1620 IWNDGIDEED IRYLKITYDK MLQQDNAHDW LNDTLWVHHP PTNMGSATGV KKKRKEDGIR 1630 1640 1650 1660 1670 1680 DHVTGCARSE GYYKIDKKDK MKYLNSSRLQ SEEPDVDTQG KSIPAQPQVS TRAGSERRSE 1690 1700 1710 1720 1730 1740 QRRLLSSFSC DSDLLKFNQL KFRKKKIRFC RSHIHDWGLF AMEPIAADEM VIEYVGQNIR 1750 1760 1770 1780 1790 1800 QVIADMREKR YEDEGIGSSY MFRVDHDTII DATKCGNFAR FINHSCNPNC YAKVITVESQ 1810 1820 1830 1840 KKIVIYSRQP INVNEEITYD YKFPIEDEKI PCLCGAENCR GTLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	"Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes." Sun X.-J., Xu P.-F., Zhou T., Hu M., Fu C.-T., Zhang Y., Jin Y., Chen Y., Chen S.-J., Huang Q.-H., Liu T.X., Chen Z. PLoS ONE 3:E1499-E1499(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1585-1740.
[3]	"Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo." Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R. J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1138, MASS SPECTROMETRY. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX088560 Genomic DNA. Translation: CAK10781.2. DQ851809 mRNA. Translation: ABI34481.1.
IPI	IPI00608851.
RefSeq	NP_001038599.2. NM_001045134.2.
UniGene	Dr.80156.
3D structure databases
ProteinModelPortal	Q1LY77.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	567970.
KEGG	dre:567970.
Organism-specific databases
CTD	567970.
ZFIN	ZDB-GENE-050309-289. setd1ba.
Phylogenomic databases
eggNOG	COG2940.
HOGENOM	HOG000168216.
HOVERGEN	HBG055596.
InParanoid	Q1LY77.
KO	K11422.
OrthoDB	EOG4933HK.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR024657. COMPASS_Set1_N-SET. IPR015722. Histone-lysine_MeTfrase. IPR012677. Nucleotide-bd_a/b_plait. IPR003616. Post-SET_dom. IPR000504. RRM_dom. IPR001214. SET_dom. [Graphical view]
PANTHER	PTHR22884:SF10. PTHR22884:SF10. 1 hit.
Pfam	PF11764. N-SET. 1 hit. PF00076. RRM_1. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00508. PostSET. 1 hit. SM00360. RRM. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50102. RRM. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20888944.

Entry information

Entry name

SE1BA_DANRE

Accession

Primary (citable) accession number: Q1LY77
Secondary accession number(s): A5XCC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 20, 2007
Last modified:	April 3, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program