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Q1LY77

- SE1BA_DANRE

UniProt

Q1LY77 - SE1BA_DANRE

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Protein

Histone-lysine N-methyltransferase SETD1B-A

Gene
setd1ba, setd1b, si:dkey-237o15.4
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleotide binding Source: InterPro
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B-A (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 1B-A
Gene namesi
Name:setd1ba
Synonyms:setd1b
ORF Names:si:dkey-237o15.4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050309-289. setd1ba.

Subcellular locationi

Nucleus speckle By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nuclear speck Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18441844Histone-lysine N-methyltransferase SETD1B-APRO_0000316996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1138 – 11381Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ1LY77.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 21689RRMAdd
BLAST
Domaini1705 – 1822118SETAdd
BLAST
Domaini1828 – 184417Post-SETAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi375 – 786412Pro-richAdd
BLAST
Compositional biasi952 – 1116165Glu-richAdd
BLAST
Compositional biasi1000 – 108081Ser-richAdd
BLAST
Compositional biasi1172 – 1435264Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000168216.
HOVERGENiHBG055596.
InParanoidiQ1LY77.
KOiK11422.
PhylomeDBiQ1LY77.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1LY77-1 [UniParc]FASTAAdd to Basket

« Hide

MCWKVEIVVY CKRQKPQTRG TQYVPGERNK LNEDHGRRQS SSLANGMDNS     50
HPICSSGEKR SHHWRSYKLI IDPALKKGSH KVYRYDGHQF STPSFGMSPV 100
DIVRDPRIGR LWTKYKETDL PVPKFKIDEC YVGRVPPKEV TFAKLNDNVR 150
EGFLTDMCKK FGDIEEVEIL YNPKNKKHLG IAKVVFETVK AAKDAVQNLH 200
NTSVMGNIIH VELDPKGENR QRYFQRLING SYTPLTLPVG GEEACDVSPR 250
SLAEALMACE PSRRLFEGGS SVVAGTTPSG TNTPMSLDTA YSSLRQDTPQ 300
SQGTPHTPRP SGTPFSQDSS YSSRQGTPAF QANRAESSGG YKSRRHETKF 350
QDAYNRRPER RYVHGPTQRG NTEQPPSFKQ HQPPEPPSPA FTHTPPPPTS 400
ANFKTAYSQY QPPIPQEYTV ASYHQPVQRE LDYRRPPQAP PPPSTDFLPV 450
RDRPTTPPIP EPPPAPETQP TTPPSSTPEP CPSPTQESER NSLDSRIEML 500
LKPFLNERGD SDAEVRMDGS PISSSSSQLS PIPPQRPSRP SSTGLEDISP 550
TPLPDSEDDE PIRGTASLLA NSRGMSPTNM HSKSCVGEPR TAIDKMDTGH 600
QSSGEDMEIS DDEMPGTPIA SGDCDKNIVV NSALSLIQTI PMPPPGFPPL 650
PHAAGFPLPP HHLPHHSTVS HLPSHHPMLH PLHSYGMMHF LPVDLLSSLP 700
QLLQMPFQMQ TQMLSRMAQS QHPYAYPYPA PSANPAAMPF GGPYPPLSVV 750
SAPADTLHGQ PWPLPSMPQF NPAVPPPGYE PQKEDPHKAT IDGVLMAIVK 800
ELKAIMKKDL NRKMVEVVAF RKFDEWWDKQ ELSAKATLTP VKTGEGKDEE 850
KERAKPKETM SSHLPWNKGE GLGFEGMGLG IGLRGIRLPS FKVKRKQPPE 900
PTSTSDNKRV RPSTPVDDEL EDEESERMGR TDGSRVDPAG SSSKRRPARP 950
LELDSEGEEE EETSGKEESS LSDHEEEPVD DASERLSSGK DLEEEDEKKS 1000
ESHSSESESS DSSDDEASSS SSSKSGSDSS GSESSSDYES SSEEEEEEEE 1050
EEERIVGMDD EEDVDARTST SSSTTSTSSS DEEEVVEVKA PSTPTGPPPE 1100
EEPNELGRLE AVDEAEIDHK PSMVSLIKTK VEEVRPPSPK GLPADELDVD 1150
LEVKIPVPKT EASLEEVGNL RPPTPTGSFA DSDQDTRPKI PTEDFPRTPG 1200
HEGPVPLESE TTVPRSLPTP SMHLPLPPSH VPDPQSLLPP PETLPDMPVR 1250
GRLPTEEDIP RTPGRDLMDR ARGLGKLQST DTVPVTPGSD TPLTGNSLSS 1300
PHILGSPFSY PAQSPVLSAG IPRTPGRDLT FAPAFPDSAG LSAGLPIHRK 1350
ASSEILEEKP LFKEPLLSAS PQASLPNNAA SSPFPGPPLP TASLPEPALP 1400
PQGSPPASIE NSFPASPKEL PVPMIDVPVP LDDTPSKKKL VRSKNKKGIQ 1450
DSEEPQVTLI EASSLPELPV NNQYPDLPSE SIKEEDGEPA FSEKEESQVP 1500
TIIPKVEETS FYVEEPIQKT RRQRRGWQEL LLSMHSPVAS PRRPSFMPRS 1550
DFEEMTILYD IWNDGIDEED IRYLKITYDK MLQQDNAHDW LNDTLWVHHP 1600
PTNMGSATGV KKKRKEDGIR DHVTGCARSE GYYKIDKKDK MKYLNSSRLQ 1650
SEEPDVDTQG KSIPAQPQVS TRAGSERRSE QRRLLSSFSC DSDLLKFNQL 1700
KFRKKKIRFC RSHIHDWGLF AMEPIAADEM VIEYVGQNIR QVIADMREKR 1750
YEDEGIGSSY MFRVDHDTII DATKCGNFAR FINHSCNPNC YAKVITVESQ 1800
KKIVIYSRQP INVNEEITYD YKFPIEDEKI PCLCGAENCR GTLN 1844
Length:1,844
Mass (Da):204,141
Last modified:February 20, 2007 - v2
Checksum:i020BC92CCB797E27
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX088560 Genomic DNA. Translation: CAK10781.2.
DQ851809 mRNA. Translation: ABI34481.1.
RefSeqiNP_001038599.2. NM_001045134.2.
UniGeneiDr.80156.

Genome annotation databases

GeneIDi567970.
KEGGidre:567970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX088560 Genomic DNA. Translation: CAK10781.2 .
DQ851809 mRNA. Translation: ABI34481.1 .
RefSeqi NP_001038599.2. NM_001045134.2.
UniGenei Dr.80156.

3D structure databases

ProteinModelPortali Q1LY77.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 567970.
KEGGi dre:567970.

Organism-specific databases

CTDi 567970.
ZFINi ZDB-GENE-050309-289. setd1ba.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000168216.
HOVERGENi HBG055596.
InParanoidi Q1LY77.
KOi K11422.
PhylomeDBi Q1LY77.

Miscellaneous databases

NextBioi 20888944.
PROi Q1LY77.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. "Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes."
    Sun X.-J., Xu P.-F., Zhou T., Hu M., Fu C.-T., Zhang Y., Jin Y., Chen Y., Chen S.-J., Huang Q.-H., Liu T.X., Chen Z.
    PLoS ONE 3:E1499-E1499(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1585-1740.
  3. "Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
    Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
    J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1138, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSE1BA_DANRE
AccessioniPrimary (citable) accession number: Q1LY77
Secondary accession number(s): A5XCC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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