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Protein
Submitted name:

Neuraminidase 1

Gene

neu1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_221391. Glycosphingolipid metabolism.
REACT_221720. Sialic acid metabolism.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuraminidase 1Imported
Submitted name:
Novel protein similar to vertebrate sialidase 1 (Lysosomal sialidase) (NEU1)Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:neu1Imported
Synonyms:si:ch211-222e23.1Imported
ORF Names:CH211-222E23.1-001Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-060503-592. neu1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015727.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4409.
GeneTreeiENSGT00720000108878.
HOGENOMiHOG000007651.
HOVERGENiHBG057314.
KOiK01186.
OMAiGTEMFAP.
OrthoDBiEOG779NXT.
TreeFamiTF331063.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1LWP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFIRQIGIL LGIAVLSSAR ADKTQIDPLI YEEQLLWVSG GAGQVNAYRI
60 70 80 90 100
PLLTFTLRGS LLAFSEARKM SSSDIGAKFI ALRRSTDRGA TWSPTSFIVD
110 120 130 140 150
DGSLADGLSL GSVVVDEETG AVIIIYSLCF HQYQCSPSST MMVQSLDDGF
160 170 180 190 200
TWSVPRNLSI ELGVKSFAPG PGFGIQKRYP PSKGRLVVCG HGTIAGDGVF
210 220 230 240 250
CILSDDHGRS WRYGAALKSI PYNQPKQDLD FNPDECQPVE LEDGSIVINV
260 270 280 290 300
RNQNNYHCRC RIIVRSLDGG ESLPVEELVF DKTLIDPVVA AGALQKQGVM
310 320 330 340 350
YFTNPSSTQH RVNLTLRWSF TDGKSWEKEA VQIWAGPSGY STMTSLKGGS
360 370 380
AEDNKYIFVV YEKGHKDYWE TISFAKIHLY GGK
Length:383
Mass (Da):42,145
Last modified:May 30, 2006 - v1
Checksum:i188A60BA1612D610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP085398 Genomic DNA. No translation available.
BC133832 mRNA. Translation: AAI33833.1.
BX537337 Genomic DNA. Translation: CAK04566.1.
RefSeqiNP_001038374.1. NM_001044909.2.
UniGeneiDr.79166.

Genome annotation databases

EnsembliENSDART00000002464; ENSDARP00000015727; ENSDARG00000008832.
GeneIDi559850.
KEGGidre:559850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP085398 Genomic DNA. No translation available.
BC133832 mRNA. Translation: AAI33833.1.
BX537337 Genomic DNA. Translation: CAK04566.1.
RefSeqiNP_001038374.1. NM_001044909.2.
UniGeneiDr.79166.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015727.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000002464; ENSDARP00000015727; ENSDARG00000008832.
GeneIDi559850.
KEGGidre:559850.

Organism-specific databases

CTDi4758.
ZFINiZDB-GENE-060503-592. neu1.

Phylogenomic databases

eggNOGiCOG4409.
GeneTreeiENSGT00720000108878.
HOGENOMiHOG000007651.
HOVERGENiHBG057314.
KOiK01186.
OMAiGTEMFAP.
OrthoDBiEOG779NXT.
TreeFamiTF331063.

Enzyme and pathway databases

ReactomeiREACT_221391. Glycosphingolipid metabolism.
REACT_221720. Sialic acid metabolism.

Miscellaneous databases

NextBioi20883171.
PROiQ1LWP9.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: OvaryImported.
  2. Woodmansey R.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ1LWP9_DANRE
AccessioniPrimary (citable) accession number: Q1LWP9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.