ID   DS22A_DANRE             Reviewed;         208 AA.
AC   Q1LWL2; Q6DGQ6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Dual specificity protein phosphatase 22-A;
DE            EC=3.1.3.48;
DE            EC=3.1.3.16;
GN   Name=dusp22a; Synonyms=dusp22; ORFNames=si:dkey-190g1.1, zgc:92816;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RG   The Danio rerio sequencing project at the Sanger Institute;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activates the Jnk signaling pathway. Dephosphorylates
CC       and deactivates p38 and stress-activated protein kinase/c-Jun N-
CC       terminal kinase (SAPK/JNK) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Non-receptor class dual specificity subfamily.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
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DR   EMBL; BX548023; CAK10906.2; -; Genomic_DNA.
DR   EMBL; BX890541; CAK10906.2; JOINED; Genomic_DNA.
DR   EMBL; BX890541; CAN87750.1; -; Genomic_DNA.
DR   EMBL; BX548023; CAN87750.1; JOINED; Genomic_DNA.
DR   EMBL; BC076284; AAH76284.1; -; mRNA.
DR   IPI; IPI00506365; -.
DR   RefSeq; NP_001002514.1; -.
DR   UniGene; Dr.75237; -.
DR   Ensembl; ENSDARG00000056396; Danio rerio.
DR   GeneID; 436787; -.
DR   KEGG; dre:436787; -.
DR   ZFIN; ZDB-GENE-040718-219; dusp22a.
DR   HOVERGEN; Q1LWL2; -.
DR   OMA; Q1LWL2; HECRLNG.
DR   BRENDA; 3.1.3.16; 96826.
DR   BRENDA; 3.1.3.48; 96826.
DR   ArrayExpress; Q1LWL2; -.
DR   Bgee; Q1LWL2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphata...; IEA:InterPro.
DR   GO; GO:0006470; P:protein amino acid dephosphorylation; IEA:InterPro.
DR   InterPro; IPR000387; Tyr_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000340; Tyr_Pase_dual_specific.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Nucleus; Protein phosphatase.
FT   CHAIN         1    208       Dual specificity protein phosphatase 22-
FT                                A.
FT                                /FTId=PRO_0000322580.
FT   DOMAIN       65    139       Tyrosine-protein phosphatase.
FT   COMPBIAS    132    181       Gln-rich.
FT   ACT_SITE     88     88       Phosphocysteine intermediate (By
FT                                similarity).
FT   CONFLICT     20     20       S -> P (in Ref. 2; AAH76284).
SQ   SEQUENCE   208 AA;  23386 MW;  F5095AE252538986 CRC64;
     MGNGMNKVID GLYLGNIRDS ENRDSLSRNG ITHILSVCNN AKPVLEDMTY LCINAADASS
     QNLSQHFKES IRFIHECRLN GGACLVHCLA GVSRSTTVVV AYLMTVTSYG WQECLTAVKA
     VRSFVGPNYG FQQQLQEFQM KQVSEYQAWL RASYRSSPFK DQEQVEALLS LFAEQQQQGQ
     QNDPEWMSQG SRIYPLSYNQ YSASGSNR
//