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Q1LWL2

- DS22A_DANRE

UniProt

Q1LWL2 - DS22A_DANRE

Protein

Dual specificity protein phosphatase 22-A

Gene

dusp22a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarityPROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Phosphocysteine intermediateBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. positive regulation of JNK cascade Source: RefGenome
    2. protein dephosphorylation Source: RefGenome
    3. regulation of cell proliferation Source: RefGenome
    4. transforming growth factor beta receptor signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 22-A (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:dusp22aImported
    Synonyms:dusp22Imported
    ORF Names:si:dkey-190g1.1, zgc:92816
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 18

    Organism-specific databases

    ZFINiZDB-GENE-040718-219. dusp22a.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Dual specificity protein phosphatase 22-APRO_0000322580Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ1LWL2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1LWL2.
    SMRiQ1LWL2. Positions 1-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 13975Tyrosine-protein phosphataseSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi132 – 18150Gln-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00730000110377.
    HOGENOMiHOG000007880.
    HOVERGENiHBG054344.
    InParanoidiQ1LWL2.
    KOiK14165.
    OMAiHILSVYN.
    OrthoDBiEOG7966HM.
    PhylomeDBiQ1LWL2.
    TreeFamiTF105126.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1LWL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNGMNKVID GLYLGNIRDS ENRDSLSRNG ITHILSVCNN AKPVLEDMTY    50
    LCINAADASS QNLSQHFKES IRFIHECRLN GGACLVHCLA GVSRSTTVVV 100
    AYLMTVTSYG WQECLTAVKA VRSFVGPNYG FQQQLQEFQM KQVSEYQAWL 150
    RASYRSSPFK DQEQVEALLS LFAEQQQQGQ QNDPEWMSQG SRIYPLSYNQ 200
    YSASGSNR 208
    Length:208
    Mass (Da):23,386
    Last modified:July 10, 2007 - v2
    Checksum:iF5095AE252538986
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201S → P in AAH76284. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548023, BX890541 Genomic DNA. Translation: CAK10906.2.
    BX890541, BX548023 Genomic DNA. Translation: CAN87750.1.
    BC076284 mRNA. Translation: AAH76284.1.
    RefSeqiNP_001002514.1. NM_001002514.1.
    UniGeneiDr.75237.

    Genome annotation databases

    EnsembliENSDART00000078888; ENSDARP00000073347; ENSDARG00000056396.
    GeneIDi436787.
    KEGGidre:436787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548023 , BX890541 Genomic DNA. Translation: CAK10906.2 .
    BX890541 , BX548023 Genomic DNA. Translation: CAN87750.1 .
    BC076284 mRNA. Translation: AAH76284.1 .
    RefSeqi NP_001002514.1. NM_001002514.1.
    UniGenei Dr.75237.

    3D structure databases

    ProteinModelPortali Q1LWL2.
    SMRi Q1LWL2. Positions 1-154.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000078888 ; ENSDARP00000073347 ; ENSDARG00000056396 .
    GeneIDi 436787.
    KEGGi dre:436787.

    Organism-specific databases

    CTDi 436787.
    ZFINi ZDB-GENE-040718-219. dusp22a.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00730000110377.
    HOGENOMi HOG000007880.
    HOVERGENi HBG054344.
    InParanoidi Q1LWL2.
    KOi K14165.
    OMAi HILSVYN.
    OrthoDBi EOG7966HM.
    PhylomeDBi Q1LWL2.
    TreeFami TF105126.

    Miscellaneous databases

    NextBioi 20831220.

    Gene expression databases

    Bgeei Q1LWL2.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.

    Entry informationi

    Entry nameiDS22A_DANRE
    AccessioniPrimary (citable) accession number: Q1LWL2
    Secondary accession number(s): Q6DGQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3