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Reviewed, UniProtKB/Swiss-Prot Q1LWL2 (DS22A_DANRE)

Last modified January 19, 2010. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dual specificity protein phosphatase 22-A
    EC=3.1.3.48
    EC=3.1.3.16
Gene names
Name: dusp22a
Synonyms: dusp22
ORF Names: si:dkey-190g1.1, zgc:92816
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) By similarity. UniProtKB Q99N11

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. UniProtKB Q99N11

A phosphoprotein + H2O = a protein + phosphate. UniProtKB Q99N11

Subcellular location

Cytoplasm By similarity. Nucleus By similarity UniProtKB Q99N11.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Dual specificity protein phosphatase 22-A
PRO_0000322580

Regions

Domain65 – 13975Tyrosine-protein phosphatase
Compositional bias132 – 18150Gln-rich

Sites

Active site881Phosphocysteine intermediate By similarity UniProtKB Q99N11

Experimental info

Sequence conflict201S → P in AAH76284. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q1LWL2-1 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: F5095AE252538986

FASTA20823,386
        10         20         30         40         50         60 
MGNGMNKVID GLYLGNIRDS ENRDSLSRNG ITHILSVCNN AKPVLEDMTY LCINAADASS 

        70         80         90        100        110        120 
QNLSQHFKES IRFIHECRLN GGACLVHCLA GVSRSTTVVV AYLMTVTSYG WQECLTAVKA 

       130        140        150        160        170        180 
VRSFVGPNYG FQQQLQEFQM KQVSEYQAWL RASYRSSPFK DQEQVEALLS LFAEQQQQGQ 

       190        200 
QNDPEWMSQG SRIYPLSYNQ YSASGSNR 

« Hide

References

[1]The Danio rerio sequencing project at the Sanger Institute
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX548023, BX890541 Genomic DNA. Translation: CAK10906.2.
BX890541, BX548023 Genomic DNA. Translation: CAN87750.1.
BC076284 mRNA. Translation: AAH76284.1.
IPIIPI00506365.
RefSeqNP_001002514.1.
UniGeneDr.75237

3D structure databases

SMRQ1LWL2. Positions 1-154.
ModBaseSearch...

Genome annotation databases

EnsemblENSDART00000078888; ENSDARP00000073347; ENSDARG00000056396; Danio rerio. [Genome view]
GeneID436787.
KEGGdre:436787.

Organism-specific databases

CTD436787.
ZFINZDB-GENE-040718-219. dusp22a.

Phylogenomic databases

eggNOGfiNOG13209.
HOGENOMHBG717377.
HOVERGENQ1LWL2.
InParanoidQ1LWL2.
OMAGNIRDSE.
OrthoDBEOG9RR92W.

Enzyme and pathway databases

BRENDA3.1.3.16. 96826.
3.1.3.48. 96826.

Gene expression databases

ArrayExpressQ1LWL2.
BgeeQ1LWL2.

Family and domain databases

InterProIPR000387. Dual-sp/Tyr_phosphatase.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDS22A_DANRE
AccessionPrimary (citable) accession number: Q1LWL2
Secondary accession number(s): Q6DGQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: January 19, 2010
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents