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Protein

Dual specificity protein phosphatase 22-A

Gene

dusp22a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Phosphocysteine intermediatePROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 22-A (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:dusp22aImported
Synonyms:dusp22Imported
ORF Names:si:dkey-190g1.1, zgc:92816
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-040718-219. dusp22a.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003225801 – 208Dual specificity protein phosphatase 22-AAdd BLAST208

Proteomic databases

PaxDbiQ1LWL2.

Expressioni

Gene expression databases

BgeeiENSDARG00000056396.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073347.

Structurei

3D structure databases

ProteinModelPortaliQ1LWL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 139Tyrosine-protein phosphataseSequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 181Gln-richSequence analysisAdd BLAST50

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.Sequence analysis

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000007880.
HOVERGENiHBG054344.
InParanoidiQ1LWL2.
KOiK14165.
OMAiQWINRSE.
OrthoDBiEOG091G0NE0.
PhylomeDBiQ1LWL2.
TreeFamiTF105126.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1LWL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGMNKVID GLYLGNIRDS ENRDSLSRNG ITHILSVCNN AKPVLEDMTY
60 70 80 90 100
LCINAADASS QNLSQHFKES IRFIHECRLN GGACLVHCLA GVSRSTTVVV
110 120 130 140 150
AYLMTVTSYG WQECLTAVKA VRSFVGPNYG FQQQLQEFQM KQVSEYQAWL
160 170 180 190 200
RASYRSSPFK DQEQVEALLS LFAEQQQQGQ QNDPEWMSQG SRIYPLSYNQ

YSASGSNR
Length:208
Mass (Da):23,386
Last modified:July 10, 2007 - v2
Checksum:iF5095AE252538986
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20S → P in AAH76284 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548023, BX890541 Genomic DNA. Translation: CAK10906.2.
BX890541, BX548023 Genomic DNA. Translation: CAN87750.1.
BC076284 mRNA. Translation: AAH76284.1.
RefSeqiNP_001002514.1. NM_001002514.1.
UniGeneiDr.75237.

Genome annotation databases

EnsembliENSDART00000078888; ENSDARP00000073347; ENSDARG00000056396.
GeneIDi436787.
KEGGidre:436787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548023, BX890541 Genomic DNA. Translation: CAK10906.2.
BX890541, BX548023 Genomic DNA. Translation: CAN87750.1.
BC076284 mRNA. Translation: AAH76284.1.
RefSeqiNP_001002514.1. NM_001002514.1.
UniGeneiDr.75237.

3D structure databases

ProteinModelPortaliQ1LWL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073347.

Proteomic databases

PaxDbiQ1LWL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000078888; ENSDARP00000073347; ENSDARG00000056396.
GeneIDi436787.
KEGGidre:436787.

Organism-specific databases

CTDi436787.
ZFINiZDB-GENE-040718-219. dusp22a.

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000007880.
HOVERGENiHBG054344.
InParanoidiQ1LWL2.
KOiK14165.
OMAiQWINRSE.
OrthoDBiEOG091G0NE0.
PhylomeDBiQ1LWL2.
TreeFamiTF105126.

Miscellaneous databases

PROiQ1LWL2.

Gene expression databases

BgeeiENSDARG00000056396.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDS22A_DANRE
AccessioniPrimary (citable) accession number: Q1LWL2
Secondary accession number(s): Q6DGQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.