Q1LWL2 (DS22A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase 22-A
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:	dusp22a
Synonyms:	dusp22
ORF Names:	si:dkey-190g1.1, zgc:92816

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) By similarity. UniProtKB Q99N11
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. UniProtKB Q99N11 A phosphoprotein + H2O = a protein + phosphate. UniProtKB Q99N11
Subcellular location	Cytoplasm By similarity. Nucleus By similarity UniProtKB Q99N11.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of JNK cascade Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome transforming growth factor beta receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Dual specificity protein phosphatase 22-A		PRO_0000322580
Regions
	Domain	65 – 139	75	Tyrosine-protein phosphatase
	Compositional bias	132 – 181	50	Gln-rich
Sites
	Active site	88	1	Phosphocysteine intermediate By similarity UniProtKB Q99N11
Experimental info
	Sequence conflict	20	1	S → P in AAH76284. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q1LWL2 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: F5095AE252538986	FASTA	208	23,386
	10 20 30 40 50 60 MGNGMNKVID GLYLGNIRDS ENRDSLSRNG ITHILSVCNN AKPVLEDMTY LCINAADASS 70 80 90 100 110 120 QNLSQHFKES IRFIHECRLN GGACLVHCLA GVSRSTTVVV AYLMTVTSYG WQECLTAVKA 130 140 150 160 170 180 VRSFVGPNYG FQQQLQEFQM KQVSEYQAWL RASYRSSPFK DQEQVEALLS LFAEQQQQGQ 190 200 QNDPEWMSQG SRIYPLSYNQ YSASGSNR

References

[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX548023, BX890541 Genomic DNA. Translation: CAK10906.2. BX890541, BX548023 Genomic DNA. Translation: CAN87750.1. BC076284 mRNA. Translation: AAH76284.1.
IPI	IPI00506365.
RefSeq	NP_001002514.1. NM_001002514.1.
UniGene	Dr.75237.
3D structure databases
ProteinModelPortal	Q1LWL2.
SMR	Q1LWL2. Positions 1-154.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000078888; ENSDARP00000073347; ENSDARG00000056396.
GeneID	436787.
KEGG	dre:436787.
Organism-specific databases
CTD	436787.
ZFIN	ZDB-GENE-040718-219. dusp22a.
Phylogenomic databases
eggNOG	fiNOG13209.
GeneTree	ENSGT00590000082869.
HOGENOM	HBG717377.
HOVERGEN	HBG054344.
InParanoid	Q1LWL2.
OMA	VAYLMTV.
OrthoDB	EOG4ZKJNK.
Gene expression databases
ArrayExpress	Q1LWL2.
Bgee	Q1LWL2.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR000387. Tyr/Dual-specificity_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DS22A_DANRE

Accession

Primary (citable) accession number: Q1LWL2
Secondary accession number(s): Q6DGQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 10, 2007
Last modified:	October 19, 2011
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program