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Protein

Splicing factor 3B subunit 3

Gene

sf3b3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-DRE-72163. mRNA Splicing - Major Pathway.
R-DRE-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor 3B subunit 3
Gene namesi
Name:sf3b3
ORF Names:zgc:55440
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-040426-2901. sf3b3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12171217Splicing factor 3B subunit 3PRO_0000276757Add
BLAST

Proteomic databases

PaxDbiQ1LVE8.
PRIDEiQ1LVE8.

Expressioni

Gene expression databases

BgeeiENSDARG00000089880.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123676.

Family & Domainsi

Sequence similaritiesi

Belongs to the RSE1 family.Curated

Phylogenomic databases

eggNOGiKOG1898. Eukaryota.
ENOG410XPFQ. LUCA.
GeneTreeiENSGT00530000063396.
HOGENOMiHOG000216677.
HOVERGENiHBG093942.
InParanoidiQ1LVE8.
KOiK12830.
OMAiHPKGIRH.
OrthoDBiEOG091G00O8.
PhylomeDBiQ1LVE8.
TreeFamiTF105685.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR004871. Cleavage/polyA-sp_fac_asu_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03178. CPSF_A. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequencei

Sequence statusi: Complete.

Q1LVE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLYNITLQR ATGISHAIHG NFSGTKQQEI VVSRGKILEL LRPDANTGKV
60 70 80 90 100
HTLLTMEVFG VVRSLMAFRL TGGTKDYVVV GSDSGRIVIL EYHPSKNMFE
110 120 130 140 150
KIHQETFGKS GCRRIVPGQF LAVDPKGRAV MIGATEKQKL VYILNRDAAA
160 170 180 190 200
RLTISSPLEA HKANTLVYHV VGVDVGFENP MFACLEMDYE EADNDPTGEA
210 220 230 240 250
AANTQQTLTF YELDLGLNHV VRKYSEALEE HGNFLITVPG GSDGPSGVLI
260 270 280 290 300
CSENYITYKN FGDQPDIRCP IPRRRNDLDD PERGMIFVCS ATHKTKSMFF
310 320 330 340 350
FLAQTEQGDI FKVTLETDEE MVTEIRMKYF DTIPVATAMC VLKTGFLFVS
360 370 380 390 400
SEFGNHYLYQ IAHLGDDDEE PEFSSAMPLE EGDTFFFQPR PLKNLVLVDE
410 420 430 440 450
QESLSPIMSC QIADLANEDT PQLYVACGRG PRSTLRVLRH GLEVSEMAVS
460 470 480 490 500
ELPGNPNAVW TVRRHVEDEF DAYIIVSFVN ATLVLSIGET VEEVTDSGFL
510 520 530 540 550
GTTPTLSCSL LGEDALVQVY PDGIRHIRAD KRVNEWKTPG KKTIIRCAVN
560 570 580 590 600
QRQVVIALTG GELVYFEMDP SGQLNEYTER KEMSADVVCM SLANVPPGEQ
610 620 630 640 650
RSRFLAVGLV DNTVRIISLD PSDCLQPLSM QALPAQPESL CIVEMGGVEK
660 670 680 690 700
QDELGEKGTI GFLYLNIGLQ NGVLLRTVLD PVTGDLSDTR TRYLGSRPVK
710 720 730 740 750
LFRVRMQGQE AVLAMSSRSW LSYSYQSRFH LTPLSYETLE YASGFASEQC
760 770 780 790 800
PEGIVAISTN TLRILALEKL GAVFNQVAFP LQYTPRKFVI HPETNNLILI
810 820 830 840 850
ETDHNAYTEA TKAQRKQQMA EEMVEAAGED ERELAAEMAA AFLNENLPEA
860 870 880 890 900
IFGAPKAGSG QWASLVRLIN PIQGNTLDLV QLEQNEAAFS VAICRFLNGG
910 920 930 940 950
DDWYVLVGVA RDMILNPRSV GGGYIYTYRI VGGGDKLEFL HKTPVEDVPL
960 970 980 990 1000
AIAPFQGRVL VGVGKLLRIY DLGKKKLLRK CENKHVPNLV TGIHTIGQRV
1010 1020 1030 1040 1050
IVSDVQESLF WVRYRRNENQ LIIFADDTYP RWITTACLLD YDTMASADKF
1060 1070 1080 1090 1100
GNICVVRLPP NTSDDVDEDP TGNKALWDRG LLNGASQKAE IIINYHIGET
1110 1120 1130 1140 1150
VLSLQKTTLI PGGSESLVYT TLSGGIGILV PFTSHEDHDF FQHLEMHMRS
1160 1170 1180 1190 1200
EFPPLCGRDH LSFRSYYFPV KNVIDGDLCE QFNSMDPHKQ KSVSEELDRT
1210
PPEVSKKLED IRTRYAF
Length:1,217
Mass (Da):135,622
Last modified:May 30, 2006 - v1
Checksum:i33E96E66373E65F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321I → M in AAH47171 (Ref. 2) Curated
Sequence conflicti432 – 4321R → G in AAH47171 (Ref. 2) Curated
Sequence conflicti661 – 6611G → C in AAH47171 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX784024 Genomic DNA. No translation available.
BC047171 mRNA. Translation: AAH47171.1.
RefSeqiNP_998668.1. NM_213503.1.
UniGeneiDr.76176.

Genome annotation databases

EnsembliENSDART00000159274; ENSDARP00000134109; ENSDARG00000103553.
GeneIDi406824.
KEGGidre:406824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX784024 Genomic DNA. No translation available.
BC047171 mRNA. Translation: AAH47171.1.
RefSeqiNP_998668.1. NM_213503.1.
UniGeneiDr.76176.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123676.

Proteomic databases

PaxDbiQ1LVE8.
PRIDEiQ1LVE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000159274; ENSDARP00000134109; ENSDARG00000103553.
GeneIDi406824.
KEGGidre:406824.

Organism-specific databases

CTDi23450.
ZFINiZDB-GENE-040426-2901. sf3b3.

Phylogenomic databases

eggNOGiKOG1898. Eukaryota.
ENOG410XPFQ. LUCA.
GeneTreeiENSGT00530000063396.
HOGENOMiHOG000216677.
HOVERGENiHBG093942.
InParanoidiQ1LVE8.
KOiK12830.
OMAiHPKGIRH.
OrthoDBiEOG091G00O8.
PhylomeDBiQ1LVE8.
TreeFamiTF105685.

Enzyme and pathway databases

ReactomeiR-DRE-72163. mRNA Splicing - Major Pathway.
R-DRE-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiQ1LVE8.

Gene expression databases

BgeeiENSDARG00000089880.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR004871. Cleavage/polyA-sp_fac_asu_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03178. CPSF_A. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSF3B3_DANRE
AccessioniPrimary (citable) accession number: Q1LVE8
Secondary accession number(s): Q802W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.