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Protein

Histone acetyltransferase KAT2B

Gene

kat2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non-histone proteins (PubMed:29174768). Involved in heart and limb development by mediating acetylation of tbx5 (PubMed:29174768).By similarity1 Publication

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei536Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • heart development Source: UniProtKB
  • internal peptidyl-lysine acetylation Source: UniProtKB
  • limb development Source: UniProtKB
  • negative regulation of centriole replication Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • rhythmic process Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Acyltransferase, Transferase
Biological processBiological rhythms, Cell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT2BBy similarity (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase PCAFBy similarity
Short name:
Histone acetylase PCAFBy similarity
Lysine acetyltransferase 2BBy similarity
P300/CBP-associated factorBy similarity
Short name:
P/CAFBy similarity
Gene namesi
Name:kat2bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-060503-207 kat2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown of kat2a and kat2b leads to impaired heart and limb development. Abnormal fin development is also observed.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004434481 – 796Histone acetyltransferase KAT2BAdd BLAST796

Proteomic databases

PaxDbiQ1LUC3

Expressioni

Developmental stagei

Expressed in the heart and tail regions throughout developmental stages.1 Publication

Gene expression databases

BgeeiENSDARG00000062634

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000085190

Structurei

3D structure databases

ProteinModelPortaliQ1LUC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini469 – 617N-acetyltransferasePROSITE-ProRule annotationAdd BLAST149
Domaini704 – 774BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni540 – 542Acetyl-CoA bindingBy similarity3
Regioni547 – 553Acetyl-CoA bindingBy similarity7
Regioni578 – 581Acetyl-CoA bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiKOG1472 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00760000119099
HOGENOMiHOG000007151
HOVERGENiHBG051710
InParanoidiQ1LUC3
KOiK06062
OMAiQVIRFPM
OrthoDBiEOG091G03ZO
PhylomeDBiQ1LUC3
TreeFamiTF105399

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR037800 GCN5
IPR016376 GCN5/PCAF
IPR000182 GNAT_dom
IPR009464 PCAF_N
PANTHERiPTHR22880:SF124 PTHR22880:SF124, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF00439 Bromodomain, 1 hit
PF06466 PCAF_N, 1 hit
PIRSFiPIRSF003048 Histone_acetylase_PCAF, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q1LUC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESTGIPQG SPAVGAAGSA PAAPGVGGTE CSGAAVGSAR IAVKKAQLRS
60 70 80 90 100
SPRPKKLEKL GVYSSCKAEG ACKCNGWKSQ NPPPTPPPPT PPRAEQPTAV
110 120 130 140 150
SLMEPCRSCS HALGDHVTHL ENVSEEEMNR LLGIVLDVEY LYTCVHKEED
160 170 180 190 200
PDTKQVYFSL FKLLRKCILQ MGRPVVEALE SPPFEKPSIE QGVNNFVQYK
210 220 230 240 250
FSHLPSKERQ TIVELAKMFL NQINYWQLET PSQKRQRAPD DDVAGYKVNY
260 270 280 290 300
TRWLCYCNVP QFCDSLPRYE ATQIFGRIFL RSVFTIMRKQ LLEQARQEKD
310 320 330 340 350
KLPPEKRTLI LTHFPKFLSM LEEEVYSHNS PIWSENFMIG LSGGQIPTVV
360 370 380 390 400
SAPPVNRSLY YSSSPAPVEL AGGGSVSPAR KTASVLEPNP GGEKRKPAEP
410 420 430 440 450
LSHEDSKRPR VVGDIPMELI NEVMSTITDP TAMLGPETSL LSAHSARDEA
460 470 480 490 500
ARLEERRGVI EFHVIGNSLN QKPNKKILMW LVGLQNVFSH QLPRMPKEYI
510 520 530 540 550
TRLVFDPKHK TLSLIKDGRV IGGICFRMFP TQGFTEIVFC AVTSNEQVKG
560 570 580 590 600
YGTHLMNHLK EYHIKHEILN FLTYADEYAI GYFKKQGFSK DIKVPKSKYV
610 620 630 640 650
GYIKDYEGAT LMGCELNPCI PYTEFSVIIK KQKEIIKKLI ERKQAQIRKV
660 670 680 690 700
YPGLSCFKEG VRQIAIESIP GIRETGWKPL GKSKELKDPD QLYSTLKNIL
710 720 730 740 750
TQVKSHPNAW PFMEPVKKNE APGYYQVIRF PMDLKTMSER LKSRYYTTRK
760 770 780 790
LFMADMQRIF TNCREYNPPE SEYYKCANLL EKFFYTKIKE AGLIDK
Length:796
Mass (Da):90,026
Last modified:May 30, 2006 - v1
Checksum:iB1B321F4A513B9E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950869 Genomic DNA No translation available.
BX957344 Genomic DNA No translation available.
RefSeqiNP_001038499.1, NM_001045034.1
UniGeneiDr.97337

Genome annotation databases

EnsembliENSDART00000090757; ENSDARP00000085190; ENSDARG00000062634
GeneIDi563942
KEGGidre:563942

Similar proteinsi

Entry informationi

Entry nameiKAT2B_DANRE
AccessioniPrimary (citable) accession number: Q1LUC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
Last sequence update: May 30, 2006
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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