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Q1LUA8

- EI3EB_DANRE

UniProt

Q1LUA8 - EI3EB_DANRE

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Protein

Eukaryotic translation initiation factor 3 subunit E-B

Gene

eif3eb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
  3. translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit E-BUniRule annotation
Short name:
eIF3e-BUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6-BUniRule annotation
Gene namesi
Name:eif3eb
Synonyms:eif3s6b
ORF Names:si:ch211-129b17.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050208-283. eif3eb.

Subcellular locationi

Cytoplasm UniRule annotation. Nucleus UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB
  4. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Eukaryotic translation initiation factor 3 subunit E-BPRO_0000365955Add
BLAST

Proteomic databases

PRIDEiQ1LUA8.

Expressioni

Gene expression databases

BgeeiQ1LUA8.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini291 – 396106PCIUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036697.
HOVERGENiHBG001097.
InParanoidiQ1LUA8.
PhylomeDBiQ1LUA8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03004. eIF3e.
InterProiIPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiPF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q1LUA8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSETNM
60 70 80 90 100
VDFAMDVYKN LYPDKEIPHS LRDKRTTVVA QLKQLQSETE PIVKMFEDPE
110 120 130 140 150
TQRQMQSTRD GRMLFEYLAD KHSFRQEYLD TLYRYAKFQY ECGNYSGAAE
160 170 180 190 200
YLYFFRVLVP STDRNALSSL WGKLASEILM QNWEAAMEDL TRLRETIDNN
210 220 230 240 250
TVSSPLQSLQ QRTWLIHWSL FVFFNHPKGR DNIIELFLYQ PQYLNAIQTM
260 270 280 290 300
CPHILRYLST AVITNKDVRK RRQVLKDLVK VIQQESYTYK DPITEFVECL
310 320 330 340 350
YVNFDFDSAQ RKLRECESVL VNDFFLVACL EDFIENARLF IFETFCRIHQ
360 370 380 390 400
CISISMLADK LNMTPEEAER WIVNLIRNAR LDAKIDSKLG HVVMGNNAVS
410 420 430 440
PYQQVIEKTK SLSFRSQMLA MNIEKKISHS NRNETPNWAA QDTGFY

Note: No experimental confirmation available.

Length:446
Mass (Da):52,602
Last modified:March 3, 2009 - v2
Checksum:i8E8CCD6B9C3317FD
GO
Isoform 2 (identifier: Q1LUA8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-446: GHVVMGNNAV...NWAAQDTGFY → QENWSVLQLPRYSRRNADL

Note: No experimental confirmation available.

Show »
Length:408
Mass (Da):48,493
Checksum:i3DEC737DC942C62A
GO

Sequence cautioni

The sequence CAK04060.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAK04061.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei390 – 44657GHVVM…DTGFY → QENWSVLQLPRYSRRNADL in isoform 2. CuratedVSP_036544Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX957242 Genomic DNA. Translation: CAK04060.1. Sequence problems.
BX957242 Genomic DNA. Translation: CAK04061.1. Sequence problems.
UniGeneiDr.5119.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX957242 Genomic DNA. Translation: CAK04060.1 . Sequence problems.
BX957242 Genomic DNA. Translation: CAK04061.1 . Sequence problems.
UniGenei Dr.5119.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q1LUA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-050208-283. eif3eb.

Phylogenomic databases

HOGENOMi HOG000036697.
HOVERGENi HBG001097.
InParanoidi Q1LUA8.
PhylomeDBi Q1LUA8.

Miscellaneous databases

NextBioi 20883737.
PROi Q1LUA8.

Gene expression databases

Bgeei Q1LUA8.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_03004. eIF3e.
InterProi IPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10317. PTHR10317. 1 hit.
Pfami PF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view ]
PIRSFi PIRSF016255. eIF3e_su6. 1 hit.
SMARTi SM00088. PINT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiEI3EB_DANRE
AccessioniPrimary (citable) accession number: Q1LUA8
Secondary accession number(s): Q1LUA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3