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Protein

Eukaryotic translation initiation factor 3 subunit E-B

Gene

eif3eb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit E-BUniRule annotation
Short name:
eIF3e-BUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6-BUniRule annotation
Gene namesi
Name:eif3eb
Synonyms:eif3s6b
ORF Names:si:ch211-129b17.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050208-283. eif3eb.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003659551 – 446Eukaryotic translation initiation factor 3 subunit E-BAdd BLAST446

Proteomic databases

PaxDbiQ1LUA8.
PRIDEiQ1LUA8.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003276.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini291 – 396PCIUniRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2758. Eukaryota.
ENOG410XQK5. LUCA.
HOGENOMiHOG000036697.
HOVERGENiHBG001097.
InParanoidiQ1LUA8.
PhylomeDBiQ1LUA8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_03004. eIF3e. 1 hit.
InterProiView protein in InterPro
IPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiView protein in Pfam
PF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiView protein in SMART
SM01186. eIF3_N. 1 hit.
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1LUA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSETNM
60 70 80 90 100
VDFAMDVYKN LYPDKEIPHS LRDKRTTVVA QLKQLQSETE PIVKMFEDPE
110 120 130 140 150
TQRQMQSTRD GRMLFEYLAD KHSFRQEYLD TLYRYAKFQY ECGNYSGAAE
160 170 180 190 200
YLYFFRVLVP STDRNALSSL WGKLASEILM QNWEAAMEDL TRLRETIDNN
210 220 230 240 250
TVSSPLQSLQ QRTWLIHWSL FVFFNHPKGR DNIIELFLYQ PQYLNAIQTM
260 270 280 290 300
CPHILRYLST AVITNKDVRK RRQVLKDLVK VIQQESYTYK DPITEFVECL
310 320 330 340 350
YVNFDFDSAQ RKLRECESVL VNDFFLVACL EDFIENARLF IFETFCRIHQ
360 370 380 390 400
CISISMLADK LNMTPEEAER WIVNLIRNAR LDAKIDSKLG HVVMGNNAVS
410 420 430 440
PYQQVIEKTK SLSFRSQMLA MNIEKKISHS NRNETPNWAA QDTGFY
Note: No experimental confirmation available.
Length:446
Mass (Da):52,602
Last modified:March 3, 2009 - v2
Checksum:i8E8CCD6B9C3317FD
GO
Isoform 2 (identifier: Q1LUA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-446: GHVVMGNNAV...NWAAQDTGFY → QENWSVLQLPRYSRRNADL

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):48,493
Checksum:i3DEC737DC942C62A
GO

Sequence cautioni

The sequence CAK04060 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAK04061 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036544390 – 446GHVVM…DTGFY → QENWSVLQLPRYSRRNADL in isoform 2. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX957242 Genomic DNA. Translation: CAK04060.1. Sequence problems.
BX957242 Genomic DNA. Translation: CAK04061.1. Sequence problems.
UniGeneiDr.5119.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEI3EB_DANRE
AccessioniPrimary (citable) accession number: Q1LUA8
Secondary accession number(s): Q1LUA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 12, 2017
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families