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Q1LUA8 (EI3EB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 3 subunit E-B

Short name=eIF3e-B
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6-B
Gene names
Name:eif3eb
Synonyms:eif3s6b
ORF Names:si:ch211-129b17.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity. HAMAP-Rule MF_03004

Subunit structure

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity HAMAP-Rule MF_03004.

Sequence similarities

Belongs to the eIF-3 subunit E family.

Contains 1 PCI domain.

Sequence caution

The sequence CAK04060.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAK04061.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q1LUA8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q1LUA8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     390-446: GHVVMGNNAV...NWAAQDTGFY → QENWSVLQLPRYSRRNADL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Eukaryotic translation initiation factor 3 subunit E-B HAMAP-Rule MF_03004
PRO_0000365955

Regions

Domain291 – 396106PCI

Natural variations

Alternative sequence390 – 44657GHVVM…DTGFY → QENWSVLQLPRYSRRNADL in isoform 2.
VSP_036544

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: 8E8CCD6B9C3317FD

FASTA44652,602
        10         20         30         40         50         60 
MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSETNM VDFAMDVYKN 

        70         80         90        100        110        120 
LYPDKEIPHS LRDKRTTVVA QLKQLQSETE PIVKMFEDPE TQRQMQSTRD GRMLFEYLAD 

       130        140        150        160        170        180 
KHSFRQEYLD TLYRYAKFQY ECGNYSGAAE YLYFFRVLVP STDRNALSSL WGKLASEILM 

       190        200        210        220        230        240 
QNWEAAMEDL TRLRETIDNN TVSSPLQSLQ QRTWLIHWSL FVFFNHPKGR DNIIELFLYQ 

       250        260        270        280        290        300 
PQYLNAIQTM CPHILRYLST AVITNKDVRK RRQVLKDLVK VIQQESYTYK DPITEFVECL 

       310        320        330        340        350        360 
YVNFDFDSAQ RKLRECESVL VNDFFLVACL EDFIENARLF IFETFCRIHQ CISISMLADK 

       370        380        390        400        410        420 
LNMTPEEAER WIVNLIRNAR LDAKIDSKLG HVVMGNNAVS PYQQVIEKTK SLSFRSQMLA 

       430        440 
MNIEKKISHS NRNETPNWAA QDTGFY 

« Hide

Isoform 2 [UniParc].

Checksum: 3DEC737DC942C62A
Show »

FASTA40848,493

References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX957242 Genomic DNA. Translation: CAK04060.1. Sequence problems.
BX957242 Genomic DNA. Translation: CAK04061.1. Sequence problems.
UniGeneDr.5119.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ1LUA8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-050208-283. eif3eb.

Phylogenomic databases

HOGENOMHOG000036697.
HOVERGENHBG001097.
PhylomeDBQ1LUA8.

Gene expression databases

BgeeQ1LUA8.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_03004. eIF3e.
InterProIPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10317. PTHR10317. 1 hit.
PfamPF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
PIRSFPIRSF016255. eIF3e_su6. 1 hit.
SMARTSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20883737.
PROQ1LUA8.

Entry information

Entry nameEI3EB_DANRE
AccessionPrimary (citable) accession number: Q1LUA8
Secondary accession number(s): Q1LUA7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries